The Role and Mechanisms of Action of Natural Compounds in the Prevention and Treatment of Cancer and Cancer Metastasis

Wang, Yunqiao; Chen, Mingtai; Yu, Han‐Qing; Yuan, Gang; Li, Luo; Xu, Xingkai; Xu, Yanneng; Sui, Xinbing; Leung, Elaine Lai-Han; Wu, Qibiao

doi:10.31083/j.fbl2706192

Cited by 8 publications

(4 citation statements)

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“…The use of active ingredients extracted from traditional herbal medicines as therapeutic agents for cancer treatment has gained significant attention in recent years, with examples such as camptothecin, paclitaxel, and vincristine [ 44 ]. Our study shows that PEC exhibits potent anti-cancer effects against BLCA both in vivo and in vitro by inducing DNA damage and disrupting the autophagic flux.…”

Section: Discussionmentioning

confidence: 99%

Pectolinarigenin inhibits bladder urothelial carcinoma cell proliferation by regulating DNA damage/autophagy pathways

Deng

Shen

et al. 2023

Cell Death Discov.

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Pectolinarigenin (PEC), an active compound isolated from traditional herbal medicine, has shown potential anti-tumor properties against various types of cancer cells. However, its mechanism of action in bladder cancer (BLCA), which is one of the fatal human carcinomas, remains unexplored. In this study, we first revealed that PEC, as a potential DNA topoisomerase II alpha (TOP2A) poison, can target TOP2A and cause significant DNA damage. PEC induced G2/M phase cell cycle arrest via p53 pathway. Simultaneously, PEC can perform its unique function by inhibiting the late autophagic flux. The blocking of autophagy caused proliferation inhibition of BLCA and further enhanced the DNA damage effect of PEC. In addition, we proved that PEC could intensify the cytotoxic effect of gemcitabine (GEM) on BLCA cells in vivo and in vitro. Summarily, we first systematically revealed that PEC had great potential as a novel TOP2A poison and an inhibitor of late autophagic flux in treating BLCA.

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Section: Discussionmentioning

confidence: 99%

Pectolinarigenin inhibits bladder urothelial carcinoma cell proliferation by regulating DNA damage/autophagy pathways

Deng

Shen

et al. 2023

Cell Death Discov.

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“…Luteolin has begun to attract the attention of researchers because of its ability to target oncogenic cell signaling pathways in different cancers. We next review the progress of luteolin research in the past five years in terms of the flavonoid's anticancer effects and molecular mechanisms [80,81].…”

Section: Anti-tumor Activity Of Luteolinmentioning

confidence: 99%

Immunopharmacological Activities of Luteolin in Chronic Diseases

Huang

Kim

Cho

2023

IJMS

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Flavonoids have been shown to have anti-oxidative effects, as well as other health benefits (e.g., anti-inflammatory and anti-tumor functions). Luteolin (3′, 4′, 5,7-tetrahydroxyflavone) is a flavonoid found in vegetables, fruits, flowers, and herbs, including celery, broccoli, green pepper, navel oranges, dandelion, peppermint, and rosemary. Luteolin has multiple useful effects, especially in regulating inflammation-related symptoms and diseases. In this paper, we summarize the studies about the immunopharmacological activity of luteolin on anti-inflammatory, anti-cardiovascular, anti-cancerous, and anti-neurodegenerative diseases published since 2018 and available in PubMed or Google Scholar. In this review, we also introduce some additional formulations of luteolin to improve its solubility and bioavailability.

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“…Despite the extensive research and knowledge on this disease, the currently available treatment options still possess safety and effectiveness problems that affect therapy outcomes and patient compliance. Considering the high predicted incidence rate and the hitherto debilitating loss of human lives, the need to identify and develop novel, efficient, and non-toxic therapeutic drugs for cancer treatment is undeniable [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Potential of Luteolin on Cancer

Çetinkaya

Baran

2023

Vaccines

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Cancer is a global concern, as the rate of incidence is increasing each year. The challenges related to the current chemotherapy drugs, such as the concerns related to toxicity, turn to cancer therapeutic research to discover alternative therapy strategies that are less toxic to normal cells. Among those studies, the use of flavonoids—natural compounds produced by plants as secondary metabolites for cancer therapy—has been a hot topic in cancer treatment. Luteolin, a flavonoid that has been present in many fruits, vegetables, and herbs, has been identified to exhibit numerous biological activities, including anti-inflammatory, antidiabetic, and anticancer properties. The anticancer property of Luteolin has been extensively researched in many cancer types and has been related to its ability to inhibit tumor growth by targeting cellular processes such as apoptosis, angiogenesis, migration, and cell cycle progression. It achieves this by interacting with various signaling pathways and proteins. In the current review, the molecular targets of Luteolin as it exerts its anticancer properties, the combination therapy that includes Luteolin with other flavonoids or chemotherapeutic drugs, and the nanodelivery strategies for Luteolin are described for several cancer types.

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The Role and Mechanisms of Action of Natural Compounds in the Prevention and Treatment of Cancer and Cancer Metastasis

Cited by 8 publications

References 0 publications

Pectolinarigenin inhibits bladder urothelial carcinoma cell proliferation by regulating DNA damage/autophagy pathways

Pectolinarigenin inhibits bladder urothelial carcinoma cell proliferation by regulating DNA damage/autophagy pathways

Immunopharmacological Activities of Luteolin in Chronic Diseases

Therapeutic Potential of Luteolin on Cancer

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