The Risk of Stroke in Patients with Psoriasis

Gelfand, Joel M.; Dommasch, Erica D.; Shin, Daniel B.; Azfar, Rahat S.; Kurd, Shanu Kohli; Wang, Xingmei; Troxel, Andrea B.

doi:10.1038/jid.2009.112

Cited by 386 publications

(395 citation statements)

References 37 publications

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“…79 Recent high quality work revealed an increased risk of stroke for mild and severe psoriasis. 80 In particular, severe psoriasis confers an increased risk of stroke not explained by major risk factors alone. 80 This increased risk of PVD and CVD was confirmed by another study, but analysis did not control for other risk factors.…”

Section: Peripheral Vascular Disease and Cerebrovascular Diseasementioning

confidence: 99%

“…80 In particular, severe psoriasis confers an increased risk of stroke not explained by major risk factors alone. 80 This increased risk of PVD and CVD was confirmed by another study, but analysis did not control for other risk factors. 25 While these studies suggest an increased risk for vascular disease, further prospective trials should aim to delineate the possibility of a causal relationship.…”

Section: Peripheral Vascular Disease and Cerebrovascular Diseasementioning

confidence: 99%

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Psoriasis and Vascular Disease—Risk Factors and Outcomes: A Systematic Review of the Literature

et al. 2011

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Section: Peripheral Vascular Disease and Cerebrovascular Diseasementioning

confidence: 99%

Section: Peripheral Vascular Disease and Cerebrovascular Diseasementioning

confidence: 99%

Psoriasis and Vascular Disease—Risk Factors and Outcomes: A Systematic Review of the Literature

et al. 2011

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“…Psoriasis hastalarında diabetes mellitus, atrial fibrilasyon, hipertansiyon, aterosklerozis, stroke, miyokard enfarktüsü, kardiyovasküler mortalite ve metabolik sendrom oranlarının yüksek olduğu uzun zamandır bilinen bir gerçektir [2][3][4][5][6][7] . Son yıllarda nötrofil ve trombosit sayısının lenfosit sayısına (N/L ve T/L oranı) oranının sistemik inflamasyonun bir göstergesi olabileceği ve birçok kardiyovasküler hastalık, maliniteler ve kronik inflamatuvar hastalıklarda prognoz ile ilişkili olduğu gösterilmiştir.…”

Section: Introductionunclassified

Mean platelet volume, neutrophil to lyphocyte ratio and platelet to lymphocyte ratio in psoriasis

Ünal¹,

Küçük²,

Ünal³

et al. 2015

TURKDERM

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“…16 Large clinical trials revealed an increased risk of myocardial infarction and stroke in patients with psoriasis. 17,18 We predict that these high-impact topics will continue to be frequently published in contemporary literature.…”

Section: Discussionmentioning

confidence: 99%

Trends in Type of Original Psoriasis Publications by Decade, 1960 to 2010

Sako

Famenini

2016

TPJ

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Context:Research investigating psoriasis has spanned decades, and as our understanding of the disease has evolved, the focus of publications has changed.Objective: We sought to characterize the trends in original psoriasis-related research from 1960 to 2010 chronologically by decade.Methods: A literature review was performed using the keyword psoriasis in the MED-LINE database. All original psoriasis-related articles published at the beginning of each decade were searched and categorized by study type and topic.Main Outcome Measure: Number of articles per topic.Results: A total of 869 original psoriasis-related articles were found. The number of publications increased 18 fold over 5 decades. The immunology and pathogenesis of psoriasis was the most frequently researched topic (36%), and retrospective studies were the most common study type (37%). Recent highly published topics included biologic therapy, genetics, and psoriasis-associated cardiovascular disease.Conclusion: Original psoriasis-related publications have grown substantially since 1960. Basic science research into the immunology and pathogenesis has been and continues to be the mainstay of psoriasis research. Recent research trends suggest the focus has expanded to topics such as psoriasis-associated cardiovascular disease, genetics, and biologic therapy. INTRODUCTIONPsoriasis is a chronic inflammatory skin condition affecting 2% of the population, and it can be physically and psychologically debilitating.1 Although psoriasis was first described in 1841, it was the 1960s that first saw a surge in psoriasis-related research. Initial studies focused on the keratinocyte, and nonmalignant proliferation and reduced differentiation were found to be hallmarks of psoriasis. Since then, considerable achievements have changed the way psoriasis is viewed. Advances in technology have allowed researchers to gain an understanding of the molecular mechanisms driving the disease. Breakthroughs in biologic therapy have revolutionized the way psoriasis is managed. Recent research suggests that patients with psoriasis have a systemic inflammatory state, putting them at increased risk of cardiovascular complications, including metabolic syndrome, peripheral vascular disease, stroke, myocardial infarction, and cardiac death.3,4 Some articles suggest that tumor necrosis factor inhibitors may decrease the risk of stroke and myocardial infarction in patients with psoriasis. 5,6 As understanding of the disease has continued to evolve over five decades, research interests have expanded. Our goal is to identify these new components to gain a better understanding of the current landscape and future direction of psoriasis-related research. On the basis of recent study findings, we hypothesized that there would be a higher proportion of recent publications investigating psoriasis-associated cardiovascular disease and biologic therapy. To our knowledge, no study has systematically examined research trends in this field. We sought to accomplish this through a literature rev...

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The Risk of Stroke in Patients with Psoriasis

Cited by 386 publications

References 37 publications

Psoriasis and Vascular Disease—Risk Factors and Outcomes: A Systematic Review of the Literature

Psoriasis and Vascular Disease—Risk Factors and Outcomes: A Systematic Review of the Literature

Mean platelet volume, neutrophil to lyphocyte ratio and platelet to lymphocyte ratio in psoriasis

Trends in Type of Original Psoriasis Publications by Decade, 1960 to 2010

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