Psoriasis and Vascular Disease—Risk Factors and Outcomes: A Systematic Review of the Literature

Patel, Rita V.; Shelling, Michael L.; Prodanovich, Srdjan; Federman, Daniel G.; Kirsner, Robert S.

doi:10.1007/s11606-011-1698-5

Cited by 79 publications

(59 citation statements)

References 99 publications

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“…Studies have found correlations between acute coronary syndromes (ACSs) and the numbers of various subsets of T cells in the blood and changes in Ab titers to oxLDL. The strikingly elevated risk for atherosclerotic disease in patients with systemic autoimmune diseases (16)(17)(18) also supports the hypothesis that adaptive immune responses promote atherosclerosis.…”

Section: Introduction: Innate Immunity Informs Adaptive Responses In supporting

confidence: 55%

Adaptive immunity in atherogenesis: new insights and therapeutic approaches

Lichtman¹,

Binder²,

Tsimikas³

et al. 2013

J. Clin. Invest.

170

171

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Many remarkable advances have improved our understanding of the cellular and molecular events in the pathogenesis of atherosclerosis. Chief among these is the accumulating knowledge of how the immune system contributes to all phases of atherogenesis, including well-known inflammatory reactions consequent to intimal trapping and oxidation of LDL. Advances in our understanding of the innate and adaptive responses to these events have helped to clarify the role of inflammation in atherogenesis and suggested new diagnostic modalities and novel therapeutic targets. Here we focus on recent advances in understanding how adaptive immunity affects atherogenesis.

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Section: Introduction: Innate Immunity Informs Adaptive Responses In supporting

confidence: 55%

Adaptive immunity in atherogenesis: new insights and therapeutic approaches

Lichtman¹,

Binder²,

Tsimikas³

et al. 2013

J. Clin. Invest.

170

171

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“…Likewise, an increased risk of CV diseases in patients with other inflammatory conditions, such as rheumatoid arthritis [22], psoriasis [23] and systemic lupus erythematous [24], independent of traditional CV risk factors, has been established. Currently, the reported results for the risk of CV disease in the setting of IBD have been ambiguous, with some studies revealing an increased risk of both ischemic heart disease and cerebrovascular accidents and others showing no associations [25][26][27][28].…”

Section: Discussionmentioning

confidence: 99%

Association between aortic stiffness and left ventricular function in inflammatory bowel disease

Aslan¹,

Sarı²,

Sarı³

et al. 2016

Cardiol J.

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“…10 An increased frequency of systemic conditions such as smoking, metabolic syndrome (MetS), cardiovascular disease and obesity have been reported in psoriasis. 8,[11][12][13][14][15][16] Such comorbidities are probably mediated by T-helper 1 (Th1) cytokines. 17 The association of psoriasis with accelerated atherogenesis is currently a topic of major interest.…”

Section: Introductionmentioning

confidence: 99%

Subclinical atherogenesis in patients with mild psoriasis: A role for IL-6?

Lise

Baptista

Petersen

et al. 2017

Rev. Assoc. Med. Bras.

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Summary Introduction: A link of psoriasis with subclinical atherosclerosis has been postulated and cytokine network might intermediate this association. Few data are available in patients with mild psoriasis. We evaluated carotid intima-media thickness (cIMT) in drug-free psoriatic individuals and controls. In parallel, we searched for associations of cIMT with disease activity indexes and serum interleukins (IL) in psoriatic patients. Method: An experienced radiologist performed the cIMT analyses. Cytokine concentrations were assessed by flow cytometry. Disease activity was evaluated based on psoriasis area and severity index (PASI) as well as body surface area (BSA). Results: Sixty-five (65) patients and 64 controls were studied. Mean age of patients (50.9 years) did not differ from controls (p=0.362). A low PASI and BSA (< 10) prevailed (69.2% and 56.9%, respectively). Median levels of IL-12p70, TNF-α, IL-1β and IL-10 were significantly lower in cases than in controls (adjusted p<0.05), while IL-6 and IL-8 medians did not differ between groups (adjusted p>0.05). Smoking habit and diabetes mellitus predominated in cases (p=0.002). An altered cIMT (≥ 0.9 mm) was more frequent in cases than in controls (23.8% versus 8.5%, adjusted p=0.045). Mean cIMT was higher in cases with a borderline significance (p=0.057). cIMT scores did not correlate to PASI (rs=0.066; p=0.250) or BSA (rs=0.175; p=0.185), but did correlate significantly with serum IL-6 (rs=0.26; p=0.005). Conclusion: Subclinical atherosclerosis was more frequent in patients with mild psoriasis than controls. cIMT in psoriatic individuals correlated with serum IL-6, pointing to an eventual proatherogenic role of IL-6 in these patients. Newer studies should clarify the connection of atherogenesis with cytokines in psoriasis.

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Psoriasis and Vascular Disease—Risk Factors and Outcomes: A Systematic Review of the Literature

Cited by 79 publications

References 99 publications

Adaptive immunity in atherogenesis: new insights and therapeutic approaches

Adaptive immunity in atherogenesis: new insights and therapeutic approaches

Association between aortic stiffness and left ventricular function in inflammatory bowel disease

Subclinical atherogenesis in patients with mild psoriasis: A role for IL-6?

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