Mean platelet volume, neutrophil to lyphocyte ratio and platelet to lymphocyte ratio in psoriasis

Ünal, Mehmet; Küçük, Adem; Ünal, Gülbahar Ürün; Balevi, Şükrü; Tol, Hüseyin; Aykol, Caner; Uyar, Mehmet

doi:10.4274/turkderm.57984

Cited by 17 publications

(24 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The R-Baux score has been used for many years for estimating the risk of mortality in severely burned patients [4]. In a number of recent publications, it has been stated that the NLR which is cheap and easily calculated at every center, is a strong indicator of infl ammation in many diseases such as cancer, cardiac, and autoimmune diseases, and can be used for estimating the prognosis of the patient [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. So we also aimed to reveal the relationship between mortality and NLR in cases that treated in our center.…”

Section: Introductionmentioning

confidence: 99%

Could neutrophil-to-lymphocyte ratio be a new mortality predictor value in severe burns?

Ali¹

2019

J Surg Surgical Res

View full text Add to dashboard Cite

Background: The aim of our study was to demonstrate if there is any relation between the neutrophilto-lymphocyte ratio (NLR) and mortality in severe burns. Methods: The records of 366 patients who were admitted to Intensive Care Unit of Burn Center of Derince Training and Research Hospital between January 2012 and December 2015 were evaluated retrospectively. The cases who were hospitalized in service or did not require intensive care were not included in the study. The cases were divided into two groups: ex-group (Group 1) and discharge group (Group 2). In both groups demographic information such as age, gender, burn scores, neutrophil counts and lymphocyte counts during admission to the hospital were recorded. NLR is the ratio of absolute neutrophil count to the absolute lymphocyte count. Results: NLR was 10.94±7.63 in the exitus group and 5.5±5.56 in the discharged group. NLR was increased in mortality group and this value was statistically signifi cant (p=0.00). Independent relationship between prognoses and NLR was shown with logistic regression analyses (Odds Ratio 0.895, 95% confi dence interval 0.856-0.936, p=0.00) Conclusion: NLR has increased in mortality group. Our study showed that NLR is correlated with probability of mortality after severe burn injuries. Therefore, it can be used as a cheap, easily obtained and new mortality predictor in severe burns.

show abstract

Section: Introductionmentioning

confidence: 99%

Could neutrophil-to-lymphocyte ratio be a new mortality predictor value in severe burns?

Ali¹

2019

J Surg Surgical Res

View full text Add to dashboard Cite

show abstract

“…Unal et al evaluated PLR, NLR, and CRP values in 320 patients with psoriasis and 200 healthy controls and reported that the increase in these parameters may be closely associated with the development of psoriasis. Although the study had a retrospective design, it had a larger patient population compared to our study (8).…”

Section: Discussionmentioning

confidence: 97%

Novel inflammatory markers in patients with psoriasis

Yavuz¹,

Yavuz²

2019

Eastern J Med

View full text Add to dashboard Cite

“…These studies also reported a positive correlation of MPV with some disease characteristics of psoriasis such as PASI score, psoriatic arthritis and disease duration [8]. In contrast, some other studies did not reveal any correlation between MPV, inflammation markers and disease characteristics of psoriasis [2]. In our study, we did not find any positive correlation between MPV, hs-CRP, ESR and disease characteristics such as PASI score, disease duration or age of onset, and we found no difference in terms of MPV values between patients with and without a family history, psoriatic nail disease and psoriatic arthritis.…”

Section: Discussionmentioning

confidence: 99%

Platelet mass index is increased in psoriasis. A possible link between psoriasis and atherosclerosis

Ünal¹

2016

Arch Med Sci Atheroscler Dis

View full text Add to dashboard Cite

Introduction: Psoriasis, whose relation with atherosclerosis etc. has long been known, is a chronic inflammatory disease. Besides providing hemostasis, platelets play important roles in inflammatory reactions and immune responses and contribute to endothelial damage, thus leading to atherosclerotic plaque formation. Mean platelet volume (MPV) has been previously reported as a platelet activation marker. Platelet mass index (PMI) is also related to platelet functionality and is thought to be a useful parameter for plaque formation capacity of platelets. Material and methods: Sex, age, age of onset, disease duration, family history, psoriasis area severity index, nail and joint involvement, platelet count, mean platelet volume, platelet mass index, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) of 320 patients with psoriasis and 200 healthy persons were evaluated. Results: Mean platelet counts were 277.7 ±73.374 and 265.06 ±59.682 (p = 0.032); MPV values were 8.248 ±1.150 and 7.442 ±1.626 (p < 0.001); and PMI values were 2259 ±545.617 and 1964 ±622.762 (p < 0.001) respectively in the psoriasis and control group. The MPV showed a significant but inverse correlation with hs-CRP (p = 0.047, r = –0.149), and no correlation with ESR (p > 0.05). Platelet count and PMI had a significant and positive correlation with ESR (p < 0.001, r = 0.404 and p < 0.001, r = 0.371), but had no correlation with hs-CRP (p > 0.05). Conclusions: Higher PMI and MPV values, which mean higher plaque formation capacity and more active platelets, in psoriasis may make psoriasis patients more sensitive to atherosclerotic plaque formation and complications. On the other hand, because of the positive PMI correlation with ESR (MPV had no correlation with ESR and had a negative correlation with CRP), PMI may be a better predictor of inflammation than MPV in psoriasis.

show abstract

Mean platelet volume, neutrophil to lyphocyte ratio and platelet to lymphocyte ratio in psoriasis

Cited by 17 publications

References 14 publications

Could neutrophil-to-lymphocyte ratio be a new mortality predictor value in severe burns?

Could neutrophil-to-lymphocyte ratio be a new mortality predictor value in severe burns?

Novel inflammatory markers in patients with psoriasis

Platelet mass index is increased in psoriasis. A possible link between psoriasis and atherosclerosis

Contact Info

Product

Resources

About