The Risk Factors of Thrombogenic, Thrombophilia, and the Principle for Heparin Prophylaxis in Personalized Medicine

Abstract

This chapter presents new views on thrombogenic risk factors, thrombophilia, and thrombotic state of readiness preceding the thrombus formation. The modern methods of laboratory diagnostics of thrombotic state of readiness are considered to initiate thromboprophylaxis in patients irrespective of the presence of thrombophilia, as well as certain thrombogenic risk factors.

Relationship Between Haemostatic and Macro-Microhemodynamic Parameters in Rats Under Experimental Exposure to Cadmium. Means of Prevention

“…The states of hypercoagulability and thrombinemia are clinically often accompanied by the expenditure of fibrinogen and thrombocytopenia, due to the «activation of blood coagulation processes» [5,6]. At the same time, it is known that long-term stimulation of the hemostasis system in chronic pathological processes and intoxication may be accompanied by the development of thrombinemia and a high level of acute-phase protein -fibrinogen, as well as an increase in the number of platelets [5,8], which was revealed in chronic intoxication in our studies.…”

“…It is impossible to take blood from experimental animals when studying the state of hemodynamics in an acute experiment before the experiment, however, taking blood samples after manipulations is not recommended in coagulology [5,6], that is why three separate groups of experimental animals were distinguished for the study of systemic hemodynamics by invasive methods: 8th group -control with daily administration of saline solution into the stomach through an atraumatic probe in the volume corresponding to the experimental series, 9th group -rats with daily intragastric administration of cadmium sulfate at a dose of 0.3 mg / kg (in terms of metal), for two months; group 10 -rats with daily intragastric administration of cadmium for two months with prophylactic administration of melatonin at a dose of 5 mg/kg.…”

Prognosis of Venous Thromboembolic Complications after Hip Replacement on the Background of Modern Thromboprophylaxis

“…As it is known, this laboratory marker reflects the activation processes of blood coagulation, fibrin formation, and subsequent thrombolysis; in other words, the elevated level of D-dimers is an evidence of the thrombotic state of readiness [21]. It is quite clear that the shift of hemostatic balance towards fibrin formation before surgery can be a precondition for excessive fibrin formation after massive iatrogenic injury.…”