Relationship Between Haemostatic and Macro-Microhemodynamic Parameters in Rats Under Experimental Exposure to Cadmium. Means of Prevention

Abstract

In experiments on Wistar rats, it was shown that the prophylactic administration of melatonin at a dose of 5 mg/kg helps to reduce the manifestations of toxic coagulopathy, preventing the development of micro- and macrohemodynamic disorders in rats with chronic cadmium intoxication. Correlations between changes in indicators of the hemostasis system with the restoration of linear and volumetric blood flow rates and a decrease in the Pourcelot peripheral resistive index were revealed. These effects correlated with a decrease in the level of lipid peroxidation products and the activity of antioxidant enzymes in the blood under the influence of melatonin. The results of the experiments suggest further studies on using melatonin for the prevention and correction of the procoagulative and pathocirculatory effects of cadmium.