The results of a comparative study of the antiviral and therapeutic effectiveness of the domestic drug Orvirem® in the treatment of children of early and preschool ages with acute respiratory viral infections

Осидак, Л В; Zarubaev, V. V.; Образцова, Е В; Афанасьева, О. И.; Головачева, Е Г; Koltsova, E.A. Koltsova

doi:10.24110/0031-403x-2017-96-5-111-118

Cited by 2 publications

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“…In the last ten years, a significant increase in the number of patients with nose and sinus pathologies, first of all, chronic rhinosinusitis, has been observed, at the same time, the tendency of these pathologies to worsen is noted [1,2,3,4,5,6,7,8].…”

Section: Introduction Introductionmentioning

confidence: 97%

Modern aspects of chronic rhinosinusitis treatment

2022

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In this work, we discuss the development of a new method of immunogenesis andtreatmentofinfectiousandinfectious-allergicchronicsinusitisanditsef-and treatment of infectious and infectious-allergic chronic sinusitis and its ef-fectivness,basedonnewtargetedmethodsofimmunocorrection,takingintofectivness, based on new targeted methods of immunocorrection, taking into accounttheseverityoftheinflammatoryprocess,currentcomplaintsanddu-account the severity of the infl ammatory process, current complaints and du-ration.52patientswereunderobservation.Theresultsoftreatmentwithanration. 52 patients were under observation. The results of treatment with an aerosolofrecombinantinterferonαа-2Ь(intheformofGripferondrops)inaerosol of recombinant interferon αа-2Ь (in the form of Gripferon drops) in differenttypesofchronicrhinosinusitiswerestudied.Ithasbeenshownthatdifferent types of chronic rhinosinusitis were studied. It has been shown that aerosoltherapywithGripferongivespromisingresults–subjectiveconditionofaerosol therapy with Gripferon gives promising results – subjective condition of patientsandrhinoscopicandendoscopicdata,aswellasimprovementofnasalpatients and rhinoscopic and endoscopic data, as well as improvement of nasal olfactoryfunctionandregulationofmucociliaryclearance,whichindicatestheolfactory function and regulation of mucociliary clearance, which indicates the effectivenessofthismethodoftreatment.effectiveness of this method of treatment

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Section: Introduction Introductionmentioning

confidence: 97%

Modern aspects of chronic rhinosinusitis treatment

2022

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“…It comprises one to four connected β- d -mannuronic acid (M) and α- l -guluronic acid (G) monomers, which are irregularly arranged in MM, MG, and GG alternative blocks . Several studies indicate that SA possesses antibacterial, antiviral, and antifungal properties. − SA has been extensively employed in some areas, including bioengineering, pharmaceutical, and food industries . SA often acts as a carrier due to its biocompatible, biodegradable, and nontoxic nature. , …”

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confidence: 99%

Development, Physical–Chemical Characterization, and Molecular Docking Simulations of Ursolic Acid–Sodium Alginate Complexes

Zhang

Wang

et al. 2021

J. Agric. Food Chem.

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The aim of this study was to fabricate ursolic acid (UA)–sodium alginate (SA) complexes to improve the dissolution rate and antioxidant abilities. The antioxidant activity was evaluated by the DPPH (1,1-diphenyl-2-trinitrophenylhydrazine) assay and the pyrogallol auto-oxidation method. For the optimal composition ratio of UA:SA (1:5, w/w), the cumulative release of UA was about 101.22 ± 1.50% for 180 min. Powder X-ray diffractometry (PXRD), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM) analyses confirmed that the crystallinity of UA was significantly reduced by forming complexes with SA. By Fourier transform infrared spectroscopy (FTIR) and molecular docking simulations, it was observed that the hydroxyl group in UA formed hydrogen bonding with the carbonyl group in SA. The DPPH scavenger activities of the complexes were also increased compared with free UA. The results indicated that SA could serve as a promising carrier for lipophilic functional food ingredients due to improved solubility and antioxidant activity.

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The results of a comparative study of the antiviral and therapeutic effectiveness of the domestic drug Orvirem® in the treatment of children of early and preschool ages with acute respiratory viral infections

Cited by 2 publications

References 0 publications

Modern aspects of chronic rhinosinusitis treatment

Modern aspects of chronic rhinosinusitis treatment

Development, Physical–Chemical Characterization, and Molecular Docking Simulations of Ursolic Acid–Sodium Alginate Complexes

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