The reproductive performance of women with hypogonadotropic hypogonadism in an in vitro fertilization and embryo transfer program

Uluğ, Ulun; Ben‐Shlomo, Izhar; Tosun, Süleyman; Erden, Halit Firat; Akman, Mehmet; Bahçeci, Mustafa

doi:10.1007/s10815-005-4914-6

Cited by 26 publications

(40 citation statements)

References 23 publications

(20 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because of the low incidence of HH, there has been no prospective study on this condition. However, retrospective studies showed that the results of ART in HH patients treated with HMG were comparable to those in women with tubal factor infertility and unexplained infertility [Ulug et al 2005;Yildirim et al 2010]. …”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

The reproductive outcome of women with hypogonadotropic hypogonadism undergoingin vitrofertilization

Yılmaz

Özgü-Erdinç

Yumusak

et al. 2015

Systems Biology in Reproductive Medicine

View full text Add to dashboard Cite

The aim of this study was to evaluate the reproductive outcome and assisted reproductive technology (ART) outcomes of patients with hypogonadotropic hypogonadism (HH) and to compare the results with male factor (MF) infertility patients. The reproductive outcome of 33 HH patients was evaluated retrospectively and compared with results of 47 patients with mild male factor infertility. For ovulation induction, human menopausal gonadotropin (hMG) was used in HH patients and recFSH was used in MF infertility patients. HH patients were divided into subgroups according to retrieved oocyte numbers and the groups were compared with each other. The main outcome measures were total gonadotropin dose used, duration of stimulation, human chorionic gonadotropin (hCG) day estradiol level and endometrial thickness, oocyte number retrieved, and rate of clinical pregnancy. ART outcomes and cycle characteristics of 33 HH patients were compared with 47 MF infertility patients. There was no difference in age and body mass index (BMI) between the groups, but mean follicle stimulating hormone FSH and luteinizing hormone LH levels were significantly lower in the HH group (p50.001). Duration of stimulation was 12.5 ± 2.06 days in the HH patients and 10.08 ± 1.62 days in the MF infertility patients and the difference was significant (p50.001). Total gonadotropin dose used was higher in the HH group than the MF infertility group (p 5 0.001). However, there were no differences in hCG day estradiol levels, endometrial thickness on hCG day, total oocyte number retrieved, MII oocyte number, and pregnancy rate. In the HH subgroups, patient ages were significantly lower in the 415 oocyte retrieved group. Although patients with HH have a long-term estrogen deficiency, their response to controlled ovarian hyperstimulation treatment is similar to normal women. However, the HH group is heterogeneous and estimating the ovarian reserve before treatment is not always possible in this group.

show abstract

Section: Resultsmentioning

confidence: 99%

“…According to the World Health Organization (WHO), patients with this disorder were defined as Group I [Sungurtekin et al 1995;Ulug et al 2005]. Whatever the underlying cause, HH results in deep infertility.…”

Section: Introductionmentioning

confidence: 99%

The reproductive outcome of women with hypogonadotropic hypogonadism undergoingin vitrofertilization

Yılmaz

Özgü-Erdinç

Yumusak

et al. 2015

Systems Biology in Reproductive Medicine

View full text Add to dashboard Cite

show abstract

“…Previous studies including HH patients have shown that both the treatment duration and gonadotropin consumption were higher compared with patients with other etiologies of infertility (9, 10). This may be the result of silent ovaries, which need to be activated before follicular response is achieved.…”

Section: Discussionmentioning

confidence: 95%

Women with hypogonadotropic hypogonadism: cycle characteristics and results of assisted reproductive techniques

Kumbak

Kahraman

2006

Acta Obstet Gynecol Scand

View full text Add to dashboard Cite

show abstract

“…Significant correlations were found between serum AMH and peak serum estradiol, number of follicles >14-17 mm on hCG day, number of MII oocytes, number of top quality embryos and cumulative gonadotropin dose used. Since IHH patients are potentially fertile and respond very well to exogenous gonadotropins, assessment of ovarian reserve or prediction of COH response is of outmost importance either to predict cycle outcomes or to prevent possible COH associated complications [25]. In this context, the results of the current study are important in two different aspects.…”

Section: Discussionmentioning

confidence: 99%

“…Anosmia, cleft lip/ cleft palate and/or syndactyly are other findings that may accompany IHH. Patients with this disorder, defined also as Group I according to World Health Organization (WHO Group I), are apparently the exact candidates for ovulation induction with exogenous gonadotropins [23,25]. Ovulation can be successfully induced with small doses of menotropins.…”

Section: Introductionmentioning

confidence: 99%

Serum anti-Mullerian hormone levels correlate with ovarian response in idiopathic hypogonadotropic hypogonadism

Sönmezer

Özmen

Atabekoglu

et al. 2012

J Assist Reprod Genet

View full text Add to dashboard Cite

Purpose The role of serum AMH levels in prediction of ovarian response in idiopathic hypogonadotropic hypogonadism (IHH) was evaluated. Material method(s) Twelve patients with IHH underwent controlled ovarian hyperstimulation (COH) for IVF were enrolled in this prospective study. Serum AMH levels were studied on the 2nd or 3rd day of an induced menstrual cycle by a preceding low-dose oral contraceptive pill treatment. A fixed dose (150-300 IU/day) of hMG was given in all COH cycles. Correlations between serum AMH levels, COH outcomes and embryological data were investigated. Results Mean serum AMH levels was 3.47±2.15 ng/mL and mean serum peak estradiol was 2196±1705 pg/mL. Mean number of follicles >14 mm, >17 mm on hCG day and MII oocytes were 4.14±3.2, 4±2.5 and 7.28±3.5, respectively. Mean number of grade A embryos and transferred embryos were 3.28 ± 2.4 and 2.5 ± 0.7, respectively. The clinical pregnancy rate per patient was 41.6 % (5/12). Positive correlations were observed between serum AMH levels and MII oocytes (r00.84), grade A embryos (r00.85), serum peak estradiol levels (r00.87), and number of follicles >14 mm (r00.83) and >17 mm (r00.81) on hCG day, respectively. Conclusion AMH appears as a promising marker of ovarian response in patients with IHH undergoing IVF.

show abstract

The reproductive performance of women with hypogonadotropic hypogonadism in an in vitro fertilization and embryo transfer program

Abstract: IVF in HH patients, in which there was a background of previous failed ovulation induction, was as successful as in women with TF infertility.

Cited by 26 publications

References 23 publications

The reproductive outcome of women with hypogonadotropic hypogonadism undergoingin vitrofertilization

The reproductive outcome of women with hypogonadotropic hypogonadism undergoingin vitrofertilization

Women with hypogonadotropic hypogonadism: cycle characteristics and results of assisted reproductive techniques

Serum anti-Mullerian hormone levels correlate with ovarian response in idiopathic hypogonadotropic hypogonadism

Contact Info

Product

Resources

About