The release of histamine by egg‐white in non‐sensitized animals

Anaphylaxis and Histamine Release in the Rabbit

“…Rabbit liver thus occasionally shows a primary release of histamine on perfusion with horse serum. However, unlike the primary histamine release regularly evoked by horse serum from cat skin (Feldberg and Schachter, 1952) or by egg white in the intact cat and rat (Schachter and Talesnik, 1952), it was only occasionally observed in rabbit liver, and never from skin or intestine. The three sensitized animals which were shocked by antigen, however, all showed markedly increased blueness of the skin, the degree of which appeared to be related to the severity of shock.…”

Studies on the mechanism of anaphylaxis: A possible basis for a pharmacologic approach to allergy

“…The histamine-releasing constituent of egg white is heat stable in the rat but heat labile in the cat. 220 Similarly, the power of horse serum to raise the plasma histamine level in nonsensitized cats is lost after boiling. These findings are relevant to the facts that specific antigens having no effect on the blood of normal patients release histamine from the blood of patients with specific sensitivities.…”

III. Definition of adverse reactions to food

“…Some studies indicate that tyramine may play a role in migraine and chronic urticaria, especially in patients treated with a MAO inhibitor (31). In addition certain foods are said to have histamine releasing properties (31,37). Examples include egg white, shellfish, strawberries, tomatoes, chocolate, citrus fruit, fish and pork.…”