The Relative Effects of Fast Neutrons and X Rays on Tumour and Normal Tissue in the Rat 1. Single doses

Sb, Field; Rh, Thomlinson; Jones, T.D.

doi:10.1259/0007-1285-40-479-834

Cited by 78 publications

(10 citation statements)

References 10 publications

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“…The neutron data show no flattening down to the greatest response level. These results are different from those of Field et al, (1967) in which a sharp change of slope in the X-ray response curve was noted.…”

Section: Tumourscontrasting

confidence: 99%

“…The electron curve shows a plateau in the effect with high doses not seen in the neutron dose response curve. These results are similar to the electron data seen in mice skin by Fowler, Kragt, Ellis, Lindop and Berry (1965) and in the rat studies by Field et al (1967). …”

Section: Skin Responsesupporting

confidence: 91%

“…This is supported by a comparison of the dose response curve for the electron irradiation with the similar one for anoxic tumours in Hawkes et al (1968). This comparison shows the OER to be about Field et al (1967). X-ray doses have been corrected to equivalent electron dose using an RBE for 14 MeV electrons of 0-8.…”

Section: R P Hill P J Cheshire Patricia J Lindop and S B Fieldmentioning

confidence: 81%

“…Experimental results which show a significant increase in the relative response of tumour to normal tissue, using fast neutrons compared with 250 kV X rays, have been reported by Field, Jones and Thomlinson (1967). In their study, the response of a rapidly growing transplanted tumour (volume doubling time~one day) in the rat was compared with the normal tissue response of the rat foot.…”

mentioning

confidence: 89%

“…A therapeutic gain factor (TGF) has been denned by Field et al (1967) as the ratio of the RBE for the tumour to that of the normal tissue for the two radiation qualities under study. A comparable ratio for these mouse data is shown in Table II.…”

Section: R P Hill P J Cheshire Patricia J Lindop and S B Fieldmentioning

confidence: 99%

See 4 more Smart Citations

A comparison of the response of tumour and normal tissue in the mouse exposed to single doses of fast neutrons or electrons

Hill¹,

Cheshire²,

Lindop³

et al. 1970

BJR

Self Cite

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Section: Tumourscontrasting

confidence: 99%

Section: Skin Responsesupporting

confidence: 91%

Section: R P Hill P J Cheshire Patricia J Lindop and S B Fieldmentioning

confidence: 81%

mentioning

confidence: 89%

Section: R P Hill P J Cheshire Patricia J Lindop and S B Fieldmentioning

confidence: 99%

See 3 more Smart Citations

A comparison of the response of tumour and normal tissue in the mouse exposed to single doses of fast neutrons or electrons

Hill¹,

Cheshire²,

Lindop³

et al. 1970

BJR

Self Cite

View full text Add to dashboard Cite

The RBE of neutrons in vivo

Phillips

Rowe

1974

Cancer

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The potential for neutrons i n radiation therapy depends on a differential in RBE for tumor versus normal tissues. To study this we compared the responses of normal and tumor tissues to 15-MeV and 252Cf neutrons with responses to 137Cs gamma o r 300-kVp x rays i n the mouse in vivo. Using 1% survival as a biological end point, the RBEs of 15-MeV and 252Cf neutrons were 2.3 and 5.1 (137Cs a t 4.5 rads/min) respectively for the EMTG tumor and 1.5 and 2.5 (137Cs a t 4.5 rads/min) respectively for bone marrow CFUs. For pulmonary and esophageal lethality, the R B E values of 15-MeV neutrons were 2.2 and 4.1. With 15-MeV neutrons, the R B E for the tumor was greater than the bone marrow CFU. The R B E for pulmonary lethality was less than that for esophageal lethality. W i t h 252Cf, the R B E for the EMTG tumor, although greater than the bone marrow CFU, was not significantly different from reported in vivo RBE values of normal tissues at comparable gamma dose rates.

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Biological characterization of a high energy neutron beam for radiation therapy

Montour

Wilson

Rogers

et al. 1974

Cancer

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In anticipation of the use of the Naval Research Laboratory (NRL) 35‐MeV neutron facility for radiotherapy by the Middle Atlantic Neutron Therapy Association (MANTA), RBE values were obtained for a diversity of biological end points. Animals were exposed to neutrons at a dose‐rate of approximately 60 rads/min, in Lucite exposure chambers which also served as scattering material. Parallel experiments were performed, using the same exposure apparatus, in which animals were exposed to 60Co gamma rays given at approximately 100 rads/min. RBE values were found as follows: mouse LD50/5 1.68; mouse LD50/30 1.80; mouse endogenous spleen colonies, 1.58; mouse thymic involution (ED50) 1.45; mouse splenic involution (ED50), 1.40; chick LD50/30 hour 1.81.

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The Relative Effects of Fast Neutrons and X Rays on Tumour and Normal Tissue in the Rat 1. Single doses

Cited by 78 publications

References 10 publications

A comparison of the response of tumour and normal tissue in the mouse exposed to single doses of fast neutrons or electrons

A comparison of the response of tumour and normal tissue in the mouse exposed to single doses of fast neutrons or electrons

The RBE of neutrons in vivo

Biological characterization of a high energy neutron beam for radiation therapy

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