A comparison of the response of tumour and normal tissue in the mouse exposed to single doses of fast neutrons or electrons

Hill, Richard P.; Cheshire, Pamela J.; Lindop, Patricia J.; Field, S. B.

doi:10.1259/0007-1285-43-516-894

Cited by 13 publications

(2 citation statements)

References 5 publications

(16 reference statements)

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“…In solid experimental tumours in C3H mice breathing warm oxygen, local control was enhanced by metronidazole in the x-ray dose ratio of 1*4 (Begg, Sheldon and Foster, 1974 (Hill et al, 1970;Fowler et al, 1974). The proportion of hypoxic cells present before irradiation under these conditions was known from other experiments to be about 10% (Fowler et al, unpublished).…”

mentioning

confidence: 89%

Radiosensitization of C3H Mouse Mammary Tumours by a 2-Nitroimidazole Drug

Sheldon¹,

Foster²,

Fowler³

1974

Br J Cancer

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Summary.-Local tumour control has been determined at 150 days after single doses of 240 kV x-rays given with or without 1 mg/g body weight of the hypoxic cell radiosensitizer Ro-07-0582. The dose required to control 500/ of the tumours (TCD50) was reduced from 4380 to 2410 rad, yielding an enhancement ratio of 1-82 i 0-07 s.e.mean. This compares favourably with the corresponding single dose gain factor for fast neutrons, which was about 1 -7.

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mentioning

confidence: 89%

Radiosensitization of C3H Mouse Mammary Tumours by a 2-Nitroimidazole Drug

Sheldon¹,

Foster²,

Fowler³

1974

Br J Cancer

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“…Oxygen depletion may have affected the results of the experiments of Hill, Cheshire, Lindop and Field (1970), who irradiated tumours with electrons at 18 krads/min and with doses in the range 1 . 5 to 5 krads, as a standard of comparison with the effects of fast neutrons .…”

Section: S B Field and D K Bewleymentioning

confidence: 99%

Effects of Dose-rate on the Radiation Response of Rat Skin

Field

Bewley

1974

International Journal of Radiation Biology and Related Studies

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Skin reactions and late deformities after irradiation of the feet of anaesthetized rats with 7 MeV electrons have been measured for dose-rates between 200 rads/min and 500 krads/min . For dose-rates up to 70 krads/min, there was no alteration in the effectiveness of the radiation, which implies that there is not a rapid form of repair of sub-lethal damage in rat skin . However, when the dose-rate was increased to 500 krads/min, there was a marked decrease in effectiveness . This observation was not made when the feet were anoxic, which implies that there is oxygen depletion at the high dose-rate . For irradiation at 500 krads/min, given in aerobic conditions, the `break-away' point occurred at about 2000 rads, above which the response of the skin was similar to that when it was made anoxic . It was concluded from this observation that the sensitive cells were at a p0 2 of 5-10 mm Hg .

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RBE values for cyclotron neutrons for effects on normal tissues and tumours as a function of dose and dose fractionation

Field

Hornsey

1971

European Journal of Cancer (1965)

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A comparison of the response of tumour and normal tissue in the mouse exposed to single doses of fast neutrons or electrons

Cited by 13 publications

References 5 publications

Radiosensitization of C3H Mouse Mammary Tumours by a 2-Nitroimidazole Drug

Radiosensitization of C3H Mouse Mammary Tumours by a 2-Nitroimidazole Drug

Effects of Dose-rate on the Radiation Response of Rat Skin

RBE values for cyclotron neutrons for effects on normal tissues and tumours as a function of dose and dose fractionation

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