The relationship of maternal and fetal toxicity in developmental toxicology bioassays with notes on the biological significance of the “no observed adverse effect level”

Chernoff, Neil; Rogers, Ellen H.; Gage, M. I.; Francis, B. Magnus

doi:10.1016/j.reprotox.2007.12.001

Cited by 66 publications

(38 citation statements)

References 17 publications

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“…In experiments using perinatal exposure, changes in the mother, such as weight loss or changes in maternal homeostasis, may interfere indirectly with the development of offspring [30][31][32][33]. The nonoccurrence of maternal toxicity seen in present experiment indicates that any change occurring with the offspring' was therefore exclusively due to exposure to fipronil.…”

Section: Discussionmentioning

confidence: 57%

Lactational Exposure to Fipronil Pesticide in Low Dose Impairs Memory in Rat Offspring

Montanha¹,

Machado²

2016

J Neurol Disord

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Perinatal exposure to pesticides has been associated with neurotoxic changes that may occur during offspring development. This work aimed to evaluate the memory behavior in young and adult offspring from Wistar rats exposed to fipronil in the lactational period. For this, pregnant rats were distributed into two groups (N = 15) constituted as follows: control (Ct) and exposed to fipronil (Fip). Fipronil (Topline®) was administrated to mothers topically, at dose of 1 mg/kg/day, from the 7-14th day of lactation. The offspring memory behavior was assessed using the new object recognition task (ORT) and eight-radial arm maze task (8-RAM). Additionally was quantified the activity of the acetylcholinesterase enzyme (AChE) and made histopathological analysis of brain tissue. Results show persistent decreased memory behavior in offspring exposed to fipronil during lactation period associated with altered AChE activity and morphological changes in the animal's brain tissue. It is concluded that lactational exposure to fipronil provoked damage to the central nervous system (CNS) including altered memory behavior with histopathological and biochemical changes.

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Section: Discussionmentioning

confidence: 57%

Lactational Exposure to Fipronil Pesticide in Low Dose Impairs Memory in Rat Offspring

Montanha¹,

Machado²

2016

J Neurol Disord

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“…(Cappon et al, 2005). In addition, all does receiving 272 20 g/day of food restriction from gestational day 6 to 29 were 273 aborted between gestational day 24 and 28 (Matsuoka et al, 274 2006 (Chernoff et al, 2008). Decreased fetal 311 weight observed at 500 mg/kg in this study was considered to be 312 attributed to decreased maternal body weight gain.…”

mentioning

confidence: 79%

Developmental toxicity assessment of the new turf herbicide, methiozolin ([5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3,3(3-methylthiophen-2-yl)-1,2-isoxazoline]), in rabbits

Lee

Song

Jeong

et al. 2015

Regulatory Toxicology and Pharmacology

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“…food and water intake reduction and weakness, fine to whole-body tremor, decreased motor activity, neuromuscular weakness, weight loss, impaired viability, or some other behavioral manifestation), which could affect pups normal development [17] . In accordance to this paradigm the 1/20 LD 50 dosage was selected to use in experiments, respectively 43 mg/kg for All and 12,5 mg/kg for Cyp.…”

Section: Animals and Treatmentsmentioning

confidence: 99%

Perinatal exposure to type I and type II pyrethroids provoke persistent behavioral effects during rat offspring development

Godinho

Anselmo

Horta

2017

MRAJ

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Background:Pesticides have been extensively used around the word but concerns over their influence on environment and health is growing. Synthetic pyrethroids are potent insecticides considered to be neurotoxicant. Hypothesis: We hypothesize that perinatal exposure to type I (Cypermethrin ) and type II (d-Allehtrin) pyrethroids would produce behavioral effects on offspring during development. Methods: Pregnant Wistar rats were exposed during gestation and lactation periods, and their pups were evaluated for somatic and sensory motor changes after weaning, and for locomotor activity, motor coordination, and anxiety-like behavior at post natal day 23 and 75 (PND23 and PND25). Results: Cyp and All provoked somatic and sensory-motor reflex alterations in weaned pups. In PND23 pups both Cyp and All decreased locomotor activity and motor coordination, and provoke anxiogenic-like effect. In PND75 pups both Cyp and All decreased locomotor activity and motor coordination. Cyp but not All provoked anxiogenic-like effect. Conclusion: Perinatal exposure to selected type I (d-allethrin) and type II (cypermethrin) pyrethroids provoked physical and sensorymotor alterations in weaned pups and persistent behavioral effects during offspring development, suggesting Cyp with a major power to cause neurotoxicity through time.

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The relationship of maternal and fetal toxicity in developmental toxicology bioassays with notes on the biological significance of the “no observed adverse effect level”

Cited by 66 publications

References 17 publications

Lactational Exposure to Fipronil Pesticide in Low Dose Impairs Memory in Rat Offspring

Lactational Exposure to Fipronil Pesticide in Low Dose Impairs Memory in Rat Offspring

Developmental toxicity assessment of the new turf herbicide, methiozolin ([5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3,3(3-methylthiophen-2-yl)-1,2-isoxazoline]), in rabbits

Perinatal exposure to type I and type II pyrethroids provoke persistent behavioral effects during rat offspring development

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