Perinatal exposure to pesticides has been associated with neurotoxic changes that may occur during offspring development. This work aimed to evaluate the memory behavior in young and adult offspring from Wistar rats exposed to fipronil in the lactational period. For this, pregnant rats were distributed into two groups (N = 15) constituted as follows: control (Ct) and exposed to fipronil (Fip). Fipronil (Topline®) was administrated to mothers topically, at dose of 1 mg/kg/day, from the 7-14th day of lactation. The offspring memory behavior was assessed using the new object recognition task (ORT) and eight-radial arm maze task (8-RAM). Additionally was quantified the activity of the acetylcholinesterase enzyme (AChE) and made histopathological analysis of brain tissue. Results show persistent decreased memory behavior in offspring exposed to fipronil during lactation period associated with altered AChE activity and morphological changes in the animal's brain tissue. It is concluded that lactational exposure to fipronil provoked damage to the central nervous system (CNS) including altered memory behavior with histopathological and biochemical changes.
Perinatal exposure to pesticides was linked to changes in neurobehavioral development of rat offspring. This study aimed to evaluate the behavior of rat offspring exposed to fipronil during the perinatal period associated with laboratory findings. For this, pregnant Wistar rats were divided into five groups (n=15) namely: control (Ct) and exposed -gestation (G), lactation (L), gestation more lactation (G+L) 7-14, and gestation more lactation (G+L) 1-21. The behavioral parameters evaluated were anxiety, aggressiveness, motor coordination, exploration and locomotion. Parameters related to physical and sensory-motor development, organ/animal weight ratio, biochemistry, histology, blood cortisol levels and Fipronil and its metabolites (sulfone and dessulfinil) in offspring brains of different groups were also assessed. Results showed an increase in anxiety and aggression and a decrease in motor coordination. The negative effects caused by pesticides appear to be dependent on their presence in brain tissue. It was observed a decrease in time to eruption of incisors, an increased weight of the offspring liver; increased serum cortisol and histological changes in the liver; fipronil and fipronil sulfone were detected in the brain of offspring. In conclusion perinatal exposure to fipronil increased the aggression and anxiety, confirming its toxicity on neurodevelopment of rat offspring. Fipronil caused decreased motor coordination in the offspring, suggesting toxicity on motor nerves. The results confirm the toxicity of fipronil on rat offspring exposed during the perinatal period.
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