The relationship between urotensin II and insulin resistance in women with gestational diabetes mellitus

Çalan, Mehmet; Arkan, Tuğba; Küme, Tuncay; Bayraktar, Fırat

doi:10.1007/s42000-018-0084-7

Cited by 11 publications

(8 citation statements)

References 33 publications

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“…The activation and increase of Ras homolog family member A (RhoA) is another possible mechanism, where UII may activate it and increases calcium concentration inside the cells through opening voltage-gated calcium channels [41]. Waist circumferences, BMI, age, and weight are all correlated positively with UII, indicating a close relation between obesity, craving, and insulin imbalance with the progression of UII increase [42].…”

Section: Discussionmentioning

confidence: 99%

Association of Serum Urotensin-II Levels with Insulin Resistance and Endothelin-I in Type-II Diabetes Mellitus Patients

Khidhir

Mahmud

Maulood

2021

eijs

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Urotensin-II (UII), a pluripotent vasoactive cyclic peptide, exhibits the progression of cardiovascular diseases and the glucose metabolic disorder of insulin resistance. Type 2 Diabetes Mellitus (T2DM) is entirely associated with insulin resistance. This study aimed to demonstrate the association of UII with insulin resistance in diabetic and non-diabetic subjects. A total of 73 male and female subjects aged 40-60 years were recruited in this case-control study. They included 35 non- diabetic subjects with a body mass index of (BMI) ≤ 25 and 38 patients with Diabetes Mellitus and BMI ≥ 25. UII levels were assessed beside other vasoactive and clinical parameters. The results revealed that patients with T2DM had elevated UII and Endothelin-I (ET-I) levels, along with positive correlations with the insulin-resistance marker of Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), blood pressure (BP), fasting blood glucose (FBG), hemoglobin A1c (HbA1C), and asymmetric dimethylarginine (ADMA). Results from stepwise multiple regressions indicated that UII correlated positively with the increases in the levels of serum cholesterol, ET-I, urea, ADMA, and FBG. This study concludes that the increase in UII level has a positive relation with insulin-resistance and the increase in ET-I level. However, UII could inhibit glucose-induced insulin secretion and, hence, can be utilized as a marker for T2DM and its complications through inflammatory microangiopathy.

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Section: Discussionmentioning

confidence: 99%

Association of Serum Urotensin-II Levels with Insulin Resistance and Endothelin-I in Type-II Diabetes Mellitus Patients

Khidhir

Mahmud

Maulood

2021

eijs

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“…Its net effectiveness on vascular tonus is to provide a balance between the endothelium-independent vasoconstriction and the endothelium-dependent vasodilatation [ 12 ] . U-II plays an important role in the development of insulin resistance, in the atherosclerosis, and the glucose metabolism [ 13 , 14 ] . Thus, U-II plays an important role in DM and its complications.…”

Section: Discussionmentioning

confidence: 99%

Role of Urotensin-II in Saphenous Vein Graft Disease

Tüysüz¹,

Bahar²

2020

Braz J Cardiovasc Surg

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Objective To elucidate the effect of diabetes mellitus (DM) on the atherosclerotic process in saphenous vein grafts by determining urotensin-II (U-II) levels in harvested saphenous veins of patients who underwent coronary artery bypass grafting (CABG). Methods Coronary artery disease (CAD) patients who underwent CABG were divided into two groups: Group I (eight non-diabetic patients; CAD group) and Group II (13 patients; DM+CAD group). All patients underwent coronary angiography prior to surgery and Gensini score was used to determine the severity of coronary atherosclerosis. Saphenous vein samples were stained with hematoxylin-eosin and U-II, then damage score, H-Score, and vein layer thicknesses were calculated and statistically evaluated. Results In light microscopic evaluation, significant difference was observed between the groups in terms of endothelial cells damage, internal elastic lamina degradation, and tunica media vascular smooth muscle cells (VSMCs) damage ( P <0.001). U-II immunoreactivity was increased in tunica adventitia in the DM+CAD group ( P =0.002). The increase in foam cells was directly proportional to the thickening of the subendothelial layer, and this increased U-II immunoreactivity. Gensini score was higher in the DM+CAD group than in the CAD group ( P =0.002). Conclusion Our results show that saphenous vein grafts are already atherosclerotic before they are grafted in CAD patients. This disease is more severe in diabetic CAD patients and these changes can be detected using U-II immunoreactivity.

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“…Meanwhile, the increased sympathetic tone not only elevates RHR, but also amplifies insulin resistance [10,11]. GDM is commonly considered as a metabolic disorder regulated by insulin resistance [12]. We further hypothesized that RHR in early pregnancy might be a possible predictor for the development of GDM.…”

Section: Introductionmentioning

confidence: 96%

Early-pregnancy maternal heart rate is related to gestational diabetes mellitus (GDM)

Chen

Wang

Zhu

2022

European Journal of Obstetrics & Gynecology and Reproductiv

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Objective: The study examined the association between resting heart rate (RHR) of early pregnancy and risk of gestational diabetes mellitus (GDM) in Chinese population. Methods: As retrospective study, medical data of 15,092 pregnant women gave birth in 2019 was collected and analyzed. The pregnant women's age, educational level, pre-pregnancy body weight, height, parity, family history of diabetes, lipid profile, blood pressure and RHR were recorded during 11 13 +6 weeks. Multivariate logistic regression analysis was used to estimate the association between maternal characteristics and RHR and GDM. And we further evaluated the predictive roll of RHR in different sub-groups defined by their body mass index (BMI), age, fasting plasma glucose (FPG), total cholesterol and triglyceride. Results: 2313 women (15.33%) were diagnosed as GDM according to 75 g OGTT. According to the quartile value of RHR, the subjects were divided into four groups. Risk of GDM increased significantly as RHR increased. In the fully adjusted model, ORs(95%CI) for the lowest vs highest quartiles of heart rate were 1(as reference), 1.14(0.97 1.33), 1.25(1.05 1.40), 1.41(1.21 1.62), respectively. In the subgroup's analysis, we found the relationship between RHR and risk of GDM was evident in women with low and normal BMI; with normal fasting plasma; and normal serum lipid level. Conclusion:The current study shows early-pregnancy maternal RHR is associated with potential risk of developing GDM.

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The relationship between urotensin II and insulin resistance in women with gestational diabetes mellitus

Cited by 11 publications

References 33 publications

Association of Serum Urotensin-II Levels with Insulin Resistance and Endothelin-I in Type-II Diabetes Mellitus Patients

Association of Serum Urotensin-II Levels with Insulin Resistance and Endothelin-I in Type-II Diabetes Mellitus Patients

Role of Urotensin-II in Saphenous Vein Graft Disease

Early-pregnancy maternal heart rate is related to gestational diabetes mellitus (GDM)

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