The aim of this study was to compare the cellular properties of endometrial tissues from fertile patients and patients having at least 3 previous in vitro fertilization failures, during the implantation window. The ultrastructural evaluation of the endometrium in the implantation window may shed light on the complexity of the implantation failure paradigm.
Materials and methods:The study involved 23 women, 14 infertile with a clinical diagnosis of repeated implantation failure (RIF) and 9 fertile, defined as the control group. Endometrial samples were examined by transmission electron microscopy (TEM).Results: In the control group, secretory vacuoles and cytoplasmic projections filled with secretory material, called pinopodes, were noted; microvilli were observed on some apical surfaces; and ciliated cells were absent. In the RIF group, the number of pinopodes was remarkably lower, with some of them being immature. Moreover, decidualization of stromal cells was not frequent and fewer epithelial cells with poor secretory vacuoles were discerned.
Conclusion:TEM analyses of endometrial samples from the RIF group revealed dramatic differences at the ultrastructural level compared to the controls, which may well be an underlying cause of their infertility.
Aim: In vitro antibacterial activity of 6-substituted-3(2H)-pyridazinone-2-acetyl-2-(substituted/nonsubstitutedbenzal/ acetophenone) hydrazone derivatives were tested in common species causing hospital-acquired infections. Material and Method: Antimicrobial activities of the compounds were performed by determining minimum inhibitory concentration (MIC) value against four Gram-positive, five Gram-negative and four Candida species fungi. Modified serial microdilution method was carried out. Reference strains of American Type Culture Collection (ATCC) were used. Results: In general, eleven compounds exhibited considerable activity. Comparatively, compound 3 exhibited strong activity against Enterobacter hormaechei and 5, 11 were the most active against Acinetobacter baumannii at 31.25 μg/mL. Compounds 1,2,3,4,8 and 10 were found to be as active as positive control ampicillin trihidrate against Stenotrophomonas maltophilia. On the other hand, compounds 1,2,3,4,7,8,9,10 and 11 showed strong antifungal activitiy as much as fluconazole against Candida tropicalis. Compound 1 was mostly active against Candida albicans, Candida glabrata, Candida parapsilosis and Candida tropicalis. It was also revealed that the antifungal activity of compounds 1, 6, 7, 8 and 9 were higher than the others. Compound 1 and 8 exhibited the best activity against Candida glabrata and Candida parapsilosis respectively. Conclusions: All tested compounds showed better activity against Gram-negative bacteria and yeast than Gram-positive bacteria. These compounds may be considered as alternative antimicrobial agents in the treatment of multiple drug resistant Gram-negative, Gram-positive bacteria and fungal pathogens. Especially, we suggested that Compound 1 and 8 might be a promising candidate of new antifungal agents
İş ortamından kaynaklanan ve kişinin sağlığını tehdit edecek birçok şey aslında önlenebilir özelliktedir. Bu alanda, İş Sağlığı ve Güvenliği (İSG) bilincinin oluşturulması temel unsurlardan biridir. Çalışmamızda, Mersin Üniversitesi Sağlık Hizmetleri Meslek Yüksekokulu'nun (SHMYO) ikinci sınıfında verilen İSG eğitiminin, öğrencilerin İSG konusundaki bilgi ve farkındalıklarına etkisinin incelenmesi amaçlanmıştır. Araştırmanın evrenini 2016-2017 eğitim-öğretim yılında Mersin Üniversitesi SHMYO'da öğrenim gören 609 öğrenci, örneklemini 187'si erkek 320'si kız toplam 507 gönüllü öğrenci oluşturmuştur. Üçlü dereceli puanlama anahtarı kullanılarak toplam 19 soruluk bir anket formu birinci ve ikinci sınıf öğrencilerine uygulanmıştır ve Statistica ve Ki-Kare Testiyle değerlendirilmiştir. Öğrencilere sorulan "İSG dersi sayesinde işçi sağlığı ve güvenliği hakkında bilgilendirildim" (P:0,001), "Sağlık alanında çalışacağım için maruz kalabileceğim kaza ve hastalıklar hakkında bilgi sahibiyim" (P:0,001), "İş kazalarında uygulanabilecek ilkyardım uygulamaları hakkında bilgi sahibiyim" (P:0,001) ve benzeri sorulara verilen yanıtlar analiz edildiğinde; birinci ve ikinci sınıf öğrencileri arasında hemen hemen tüm sorularda istatistiksel olarak anlamlı fark saptanmıştır. Çalışmamızda birinci ve ikinci sınıf öğrencilerimizin sorulara verdiği cevaplardaki farklar, İSG eğitiminin, öğrencilerin İSG konusundaki bilgi birikimlerini arttırdığı ve tutumlarını olumlu yönde etkilediğini göstermektedir.
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