A light microscopic investigation of the renoprotective effects of α-lipoic acid and α-tocopherol in an experimental diabetic rat model

Kuştepe, Elif Kayhan; Bahar, Leyla; Zayman, Emrah; Sucu, Nehir; Gül, Semir; Gül, Mehmet

doi:10.1080/10520295.2019.1695942

Cited by 5 publications

(3 citation statements)

References 69 publications

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“…A signifi cant increase in the capsular space area was also observed in the ALAD group, suggesting a delay in the glomerulosclerosis process and improvement in the glomerular fi ltration process. This result corroborates the fi nding by Kustepe and collaborators [45], who compared antioxidants and found that intraperitoneal use of ALA for 15 days preserved renal morphology with reduced tissue apoptosis. In the study by Feng and collaborators [46], there was also the preservation of kidney functionality through the reduction of oxidative effects.…”

Section: Discussionsupporting

confidence: 91%

“…The use of ALA offered an important protection to the renal parenchyma, which suggests that diabetic patients can delay the progression of renal damage with its use as an auxiliary treatment. ALA contributes to the treatment of chronic diseases; in DN it improves clinical and biochemical parameters [19] by decreasing oxidative stress [39] by inhibiting renal apoptosis [45].…”

Section: Discussionmentioning

confidence: 99%

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Reduction in Glomerular and Renal Tubular Damage in Kidneys of Diabetic Rats Supplemented with Alpha-Lipoic Acid

et al. 2022

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Chronic hyperglycemia caused by diabetes results in systemic damage to the body, and the kidney ends up being the target of tissue damage. The use of antioxidants such as alpha-lipoic acid (ALA) has been shown to improve clinical and biochemical parameters in diabetic patients as they help in the prevention of oxidative stress. The present study aimed to undertake a comparative evaluation of the renal morphology of normal and diabetes-induced Wistar rats supplemented with ALA. The experiment had 4 experimental groups (n=7): a control group and a diabetic group that were fed commercial food; an alpha-lipoic group and an alpha-lipoic diabetic group that received the ALA supplement. Diabetes was induced with a single intraperitoneal injection of alloxane monohydrate administered after fasting. After 60 days of the experiment, the kidneys were excised to study the histomorphometric and stereological parameters of the glomeruli and renal tubules and the immunohistochemical parameters with a podocyte count. In the evaluation, the ALA promoted improvement in all of the relevant parameters of the glomerular areas and attenuation of tubular lesions of diabetic animals (p<0.001). Supplementation with ALA also showed beneficial effects in diabetic animals, such as reducing hyperglycemia and the damage promoted by oxidative stress alongside promoting a protective effect on the renal parenchyma. The reduction of glomerular and tubular damage delayed the advance of diabetic nephropathy and its complications, preventing renal failure in diabetic groups.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Reduction in Glomerular and Renal Tubular Damage in Kidneys of Diabetic Rats Supplemented with Alpha-Lipoic Acid

et al. 2022

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“…Our data showed decreases in the levels of TG, VLDL and Schiff bases and increases in the levels of retinol in patients with T1DM and DN [3,158]. The combined use of α-LA and α-tocopherol had a positive effect on kidney histopathology in a rat model with STZ-induced DM [159]. The administration of alpha lipoamide, a derivative of α-LA, significantly improved mitochondrial dysfunction and tubulointerstitial fibrous lesions in db/db mice, as well as increasing CDX2 and CFTR expression and decreasing β-catenin and snail expression in the kidneys of the mice [160].…”

Section: α-Lipoic Acidsupporting

confidence: 51%

Diabetic Nephropathy: Significance of Determining Oxidative Stress and Opportunities for Antioxidant Therapies

Darenskaya

Kolesnikov

Semenova

et al. 2023

IJMS

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Diabetes mellitus (DM) belongs to the category of socially significant diseases with epidemic rates of increases in prevalence. Diabetic nephropathy (DN) is a specific kind of kidney damage that occurs in 40% of patients with DM and is considered a serious complication of DM. Most modern methods for treatments aimed at slowing down the progression of DN have side effects and do not produce unambiguous positive results in the long term. This fact has encouraged researchers to search for additional or alternative treatment methods. Hyperglycemia has a negative effect on renal structures due to a number of factors, including the activation of the polyol and hexosamine glucose metabolism pathways, the activation of the renin–angiotensin–aldosterone and sympathetic nervous systems, the accumulation of advanced glycation end products and increases in the insulin resistance and endothelial dysfunction of tissues. The above mechanisms cause the development of oxidative stress (OS) reactions and mitochondrial dysfunction, which in turn contribute to the development and progression of DN. Modern antioxidant therapies for DN involve various phytochemicals (food antioxidants, resveratrol, curcumin, alpha-lipoic acid preparations, etc.), which are widely used not only for the treatment of diabetes but also other systemic diseases. It has also been suggested that therapeutic approaches that target the source of reactive oxygen species in DN may have certain advantages in terms of nephroprotection from OS. This review describes the significance of studies on OS biomarkers in the pathogenesis of DN and analyzes various approaches to reducing the intensity of OS in the prevention and treatment of DN.

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Biochemical and histopathological investigation of the protective effects of melatonin and vitamin E against the damage caused by acetamiprid in Balb-c mouse testicles at light and electron microscopic level

Zayman

Gül

Erdemli

et al. 2022

Environ Sci Pollut Res

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A light microscopic investigation of the renoprotective effects of α-lipoic acid and α-tocopherol in an experimental diabetic rat model

Cited by 5 publications

References 69 publications

Reduction in Glomerular and Renal Tubular Damage in Kidneys of Diabetic Rats Supplemented with Alpha-Lipoic Acid

Reduction in Glomerular and Renal Tubular Damage in Kidneys of Diabetic Rats Supplemented with Alpha-Lipoic Acid

Diabetic Nephropathy: Significance of Determining Oxidative Stress and Opportunities for Antioxidant Therapies

Biochemical and histopathological investigation of the protective effects of melatonin and vitamin E against the damage caused by acetamiprid in Balb-c mouse testicles at light and electron microscopic level

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