Biochemical and histopathological investigation of the protective effects of melatonin and vitamin E against the damage caused by acetamiprid in Balb-c mouse testicles at light and electron microscopic level

Zayman, Emrah; Gül, Mehmet; Erdemli, Mehmet Erman; Gül, Semir; Bağ, Harika Gözükara; Taşlıdere, Elif

doi:10.1007/s11356-022-19143-9

Cited by 3 publications

(3 citation statements)

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“…Mice, rats, and hamsters were the subjects of 13 ( 35 – 38 , 43 – 51 ), 24 ( 17 , 39 – 42 , 52 – 70 ), and one ( 71 ) studies, respectively. Studies have utilized heavy metals (n= 12) including arsenic ( 37 , 45 , 67 ), lead ( 58 ), cadmium ( 42 , 47 , 48 , 55 , 68 , 69 ), Hexavalent chromium ( 38 ), and Potassium dichromate ( 52 ) and toxic materials (n= 26) including sodium fluoride (NaF) ( 61 ), 2-Bromopropane ( 54 ), Bisphenol A ( 17 , 43 , 46 , 59 , 62 , 63 , 70 ), thioacetamide ( 56 ), Bisphenol S ( 71 ), ochratoxin A ( 57 ), nicotine ( 49 ), Cigarette smoke ( 39 ), diazinon ( 35 , 36 , 50 ), formaldehyde ( 40 , 60 ), bis(2-ethylhexyl) phthalate (DEHP) ( 44 ), carbon tetrachloride (CCl4) ( 41 , 53 ), Chlorpyrifos ( 65 , 66 ), nonylphenol ( 64 ), and acetamiprid ( 51 ) to induce oxidative stress. To administer the stressors, oral (n= 19) ( 37 , 44 – 46 , 51 , 52 , 57 – 59 , 63 – 72 ), intraperitoneal (n= 14, IP) ( 35 , 36 , 38 , 40 –…”

Section: Resultsmentioning

confidence: 99%

“…Studies have utilized heavy metals (n= 12) including arsenic ( 37 , 45 , 67 ), lead ( 58 ), cadmium ( 42 , 47 , 48 , 55 , 68 , 69 ), Hexavalent chromium ( 38 ), and Potassium dichromate ( 52 ) and toxic materials (n= 26) including sodium fluoride (NaF) ( 61 ), 2-Bromopropane ( 54 ), Bisphenol A ( 17 , 43 , 46 , 59 , 62 , 63 , 70 ), thioacetamide ( 56 ), Bisphenol S ( 71 ), ochratoxin A ( 57 ), nicotine ( 49 ), Cigarette smoke ( 39 ), diazinon ( 35 , 36 , 50 ), formaldehyde ( 40 , 60 ), bis(2-ethylhexyl) phthalate (DEHP) ( 44 ), carbon tetrachloride (CCl4) ( 41 , 53 ), Chlorpyrifos ( 65 , 66 ), nonylphenol ( 64 ), and acetamiprid ( 51 ) to induce oxidative stress. To administer the stressors, oral (n= 19) ( 37 , 44 – 46 , 51 , 52 , 57 – 59 , 63 – 72 ), intraperitoneal (n= 14, IP) ( 35 , 36 , 38 , 40 – 42 , 47 – 50 , 54 , 56 , 60 , 62 ), and subcutaneous (n= 2, SQ) ( 55 , 63 ) routes were used. To administer melatonin, oral (n= 9) ( 37 , …”

Section: Resultsmentioning

confidence: 99%

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Protective effects of melatonin against the toxic effects of environmental pollutants and heavy metals on testicular tissue: A systematic review and meta-analysis of animal studies

et al. 2023

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BackgroundEnvironmental pollution and infertility are two modern global challenges that agonize personal and public health. The causal relationship between these two deserves scientific efforts to intervene. It is believed that melatonin maintains antioxidant properties and may be utilized to protect the testicular tissue from oxidant effects caused by toxic materials.MethodsA systematic literature search was conducted in PubMed, Scopus, and Web of Science to identify the animal trial studies that evaluated melatonin therapy’s effects on rodents’ testicular tissue against oxidative stress caused by heavy metal and non-heavy metal environmental pollutants. Data were pooled, and standardized mean difference and 95% confidence intervals were estimated using the random-effect model. Also, the risk of bias was assessed using the Systematic Review Centre for Laboratory animal Experimentation (SYRCLE) tool. (PROSPERO: CRD42022369872)ResultsOut of 10039 records, 38 studies were eligible for the review, of which 31 were included in the meta-analysis. Most of them showed beneficial effects of melatonin therapy on testicular tissue histopathology. [20 toxic materials were evaluated in this review, including arsenic, lead, hexavalent chromium, cadmium, potassium dichromate, sodium fluoride, cigarette smoke, formaldehyde, carbon tetrachloride (CCl4), 2-Bromopropane, bisphenol A, thioacetamide, bisphenol S, ochratoxin A, nicotine, diazinon, Bis(2-ethylhexyl) phthalate (DEHP), Chlorpyrifos (CPF), nonylphenol, and acetamiprid.] The pooled results showed that melatonin therapy increased sperm count, motility, viability and body and testicular weights, germinal epithelial height, Johnsen's biopsy score, epididymis weight, seminiferous tubular diameter, serum testosterone, and luteinizing hormone levels, testicular tissue Malondialdehyde, glutathione peroxidase, superoxide dismutase, and glutathione levels. On the other hand, abnormal sperm morphology, apoptotic index, and testicular tissue nitric oxide were lower in the melatonin therapy arms. The included studies presented a high risk of bias in most SYRCLE domains.ConclusionIn conclusion, our study demonstrated amelioration of testicular histopathological characteristics, reproductive hormonal panel, and tissue markers of oxidative stress. Melatonin deserves scientific attention as a potential therapeutic agent for male infertility.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO, identifier CRD42022369872.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Protective effects of melatonin against the toxic effects of environmental pollutants and heavy metals on testicular tissue: A systematic review and meta-analysis of animal studies

et al. 2023

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“…Moreover, quercetin has also been proven to upregulate antioxidant levels [ 21 ]. Many people like to face health problems through natural products; some believe it has less side effects; also, there are many reported studies that focus on natural products and their role in protecting against many health problems [ 22 – 26 ]. All these facts encouraged us to focus on quercetin as a crucial natural product and investigate it through different aspects as molecular docking studies to explore its binding mode and affinity to the desired molecular targets, in vitro screening assay against panel of biological biomarkers and through in vivo studies also to get better insights from different investigating pathways.…”

Section: Introductionmentioning

confidence: 99%

Biological Effect of Quercetin in Repairing Brain Damage and Cerebral Changes in Rats: Molecular Docking and In Vivo Studies

Mehany

Belal

Santali

et al. 2022

BioMed Research International

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This study examined the protective effect of quercetin against high-altitude-induced brain damage in rats. A molecular docking study was performed to investigate the potential effect of quercetin in reducing brain damages through its ability to target the oxidative stress enzymes. Biomarker assessment screening assays were also performed then followed by in vivo studies. Three groups of rats were divided into the control group, an untreated animal model group with induced brain damage, and finally, the quercetin treated group that received quercetin dose equal to 20 mg/kg of their body weights. Molecular docking studies and biomarker assessment screening assays proved the potential effect of quercetin to affect the level of representative biomarkers glutathione (GSH), glutathione reductase (GR), glutathione-S-transferase (GST), glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA). Additionally, the protective effect of quercetin against high altitude, low pressure, and low oxygen was also investigated by exploring the brain histopathology of experimental rats. Brain damage was observed in the untreated animal model group. After treatment with quercetin, the cerebral edema in the brain tissues was improved significantly, confirming the protective effects of quercetin. Therefore, quercetin can be used as a natural food additive to protect from the highaltitude-induced brain damage.

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Reproductive effects of pubertal exposure to neonicotinoid thiacloprid in immature male mice

Zou

Zhang

Yue

et al. 2023

Toxicology and Applied Pharmacology

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Biochemical and histopathological investigation of the protective effects of melatonin and vitamin E against the damage caused by acetamiprid in Balb-c mouse testicles at light and electron microscopic level

Cited by 3 publications

References 53 publications

Protective effects of melatonin against the toxic effects of environmental pollutants and heavy metals on testicular tissue: A systematic review and meta-analysis of animal studies

Protective effects of melatonin against the toxic effects of environmental pollutants and heavy metals on testicular tissue: A systematic review and meta-analysis of animal studies

Biological Effect of Quercetin in Repairing Brain Damage and Cerebral Changes in Rats: Molecular Docking and In Vivo Studies

Reproductive effects of pubertal exposure to neonicotinoid thiacloprid in immature male mice

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