The Relationship between Total Calvarial Thickness and Diploe in the Elderly

Sabancıoğulları, Vedat; Şalk, İsmail; Çimen, Mehmet

doi:10.4067/s0717-95022013000100005

Cited by 7 publications

(6 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another study demonstrated significant differences between male and female parietal bones, with men displaying a superior skull thickness in specific regions but inferior thickness in others 4 . The notion of a genetic and sexual effect on parietal thickness was confirmed in another study that comprised a large number of African Americans and Caucasian Americans 2,4,5 . In contrast, other studies reported that the parietal bone does not display a sexual dimorphism 6–8 …”

Section: Introductionmentioning

confidence: 90%

“…4 The notion of a genetic and sexual effect on parietal thickness was confirmed in another study that comprised a large number of African Americans and Caucasian Americans. 2,4,5 In contrast, other studies reported that the parietal bone does not display a sexual dimorphism. [6][7][8] To date, most clinical and experimental studies of the effect of genes on bone density, porosity and microarchitecture, as well as genetic determinants of osteoporosis, have focused on morphometric traits in the long bones (e.g.…”

mentioning

confidence: 86%

“…Previous clinical studies have supported the notion of genetic regulation of parietal bone thickness, and controversial reports were published on the possible sex effect for this trait. [3][4][5][6][7][8] Notably, one study conducted in 500 Americans reported that the effect of sex was dependent on race. 5 In this population, there was a significant sex-related difference in parietal bone thickness for the Caucasian, but not the African Americans.…”

Section: F I G U R Ementioning

confidence: 99%

“…A study of 281 skulls from African American and Caucasian men and women reported that both race and sex have a partial effect on specific regions of the parietal bone 3 . Another study demonstrated significant differences between male and female parietal bones, with men displaying a superior skull thickness in specific regions but inferior thickness in others 4 . The notion of a genetic and sexual effect on parietal thickness was confirmed in another study that comprised a large number of African Americans and Caucasian Americans 2,4,5 .…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

A study of the influence of genetic variance and sex on the density and thickness of the calvarial bone in collaborative cross mice

Kaspersky,

Levy,

Nashef

et al. 2023

Anim Models and Exp Med

View full text Add to dashboard Cite

BackgroundBone microarchitecture is affected by multiple genes, each having a small effect on the external appearance. It is thus challenging to characterize the genes and their specific effect on bone thickness and porosity. The purpose of this study was to assess the heritability and the genetic variation effect, as well as the sex effect on the calvarial bone thickness (Ca.Th) and calvarial porosity (%PoV) using the Collaborative Cross (CC) mouse population.MethodsIn the study we examined the parietal bones of 56 mice from 9 lines of CC mice. Morphometric parameters were evaluated using microcomputed tomography (μCT) and included Ca.Th and %PoV. We then evaluated heritability, genetic versus environmental variance and the sex effect for these parameters.ResultsOur morphometric analysis showed that Ca.Th and %PoV are both significantly different among the CC lines with a broad sense heritability of 0.78 and 0.90, respectively. The sex effect within the lines was significant in line IL111 and showed higher values of Ca.Th and %PoV in females compared to males. In line IL19 there was a borderline sex effect in Ca.Th in which males showed higher values than females.ConclusionsThese results stress the complexity of sex and genotype interactions controlling Ca.Th and %PoV, as the skeletal sexual dimorphism was dependent on the genetic background. This study also shows that the CC population is a powerful tool for establishing the genetic effect on these traits.

show abstract

Section: Introductionmentioning

confidence: 90%

mentioning

confidence: 86%

Section: F I G U R Ementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A study of the influence of genetic variance and sex on the density and thickness of the calvarial bone in collaborative cross mice

Kaspersky,

Levy,

Nashef

et al. 2023

Anim Models and Exp Med

View full text Add to dashboard Cite

show abstract

“…In rat the thickness of calvarial bone is 1 mm [13], therefore, the volume of a burr hole with 6 mm in diameter is 28 mm 3 . The human skull has a variable thickness in the range between 5.3 mm and 8.4 mm, 6.62 AE 0.08 mm [14,15]. Thus, using the cylinder volume calculation, the average volume of a standard human burr hole with 16 mm diameter is 1,331 mm 3 and ranging from 1,066 to 1,685 mm 3 .…”

Section: Animal Modelmentioning

confidence: 99%

Safety and efficacy of in vitro generated bone-like material for in vivo bone regeneration – a feasibility study

Rosenberg

2020

Heliyon

View full text Add to dashboard Cite

Bone-like viable tissue can be generated in vitro by utilizing a combination of inorganic matrix, osteoblasts, osteogenic media and application of adequate mechanical stimulation of the cells. To pursue the proof that the in vitro generated bone-like tissue (BLT) is capable of bridging a critical bone gap in vivo without adverse effects, the in vitro cytotoxicity method (MTT) and murine in vivo model were implemented, by implanting the BLT into calvaria critical bone gap in rats. The endpoints for the evaluation of this concept were histological and radiographic data which should show the effectiveness of this method. We found that there was no cytotoxic effect of the BLT according to the MTT assay and no carcinogenic or other morbid effects of the BLT in vivo (mice experiment, n ¼ 10) The critical gaps in BLT -implanted animals (experimental model with rats) demonstrated full bridging of the calvaria critical bone gap with vascularized woven bone (n ¼ 3) as opposed to animals treated with vehicle material (n ¼ 3), which maintained an open gap without any visible closure, according to gross examination, X-ray imaging and histological analysis. The newly formed bone tissue was characterized by pronounced presence of bone marrow regions and newly formed host blood vessels, a strong indication for functional osseointegration. Therefore, the in vitro generated BLT, which causes bone regeneration in critical gaps, has the translational potential to bridge bone non-union defects, without harmful systemic or cytotoxic effects. These initial feasibility results indicate a high safety profile following in vivo implantation of BLT and its potential clinical ability to be used as autologous bone graft.

show abstract