The relationship between serum uric acid and metabolic syndrome in premenopausal and postmenopausal women in the Jinchang Cohort

He, Shijiao; Chan, Ckk; Xie, Zhidong; Shi, Dongxia; Hu, Xiaobin; Li, Haiyan; Wang, Dennis; Wang, Minzhen; Bai, Yana

doi:10.1080/09513590.2016.1214261

Cited by 17 publications

(11 citation statements)

References 26 publications

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“…However, it is important to note that these women are younger and have a different menopausal status, compared to the older female participants from the HWCS. Studies that have evaluated the association between hyperuricemia and metabolic syndrome by hormonal status have had conflicting results, with some reporting similar odds in both groups, [49,50] while others found a stronger relationship in premenopausal women [51]. These studies differ from ours in terms of the age range and mean BMI of the participants.…”

Section: Discussioncontrasting

confidence: 79%

Influence of Genetic and Non-Genetic Risk Factors for Serum Uric Acid Levels and Hyperuricemia in Mexicans

et al. 2019

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Risk of hyperuricemia is modified by genetic and environmental factors. Our aim was to identify factors associated with serum uric acid levels and hyperuricemia in Mexicans. A pilot Genome-wide association study GWAS was performed in a subgroup of participants (n = 411) from the Health Workers Cohort Study (HWCS). Single nucleotide polymorphisms (SNPs) associated with serum uric acid levels were validated in all the HWCS participants (n = 1939) and replicated in independent children (n = 1080) and adult (n = 1073) case-control studies. The meta-analysis of the whole HWCS and replication samples identified three SLC2A9 SNPs: rs1014290 (p = 2.3 × 10−64), rs3775948 (p = 8.2 × 10−64) and rs11722228 (p = 1.1 × 10−17); and an ABCG2 missense SNP, rs2231142 (p = 1.0 × 10−18). Among the non-genetic factors identified, the visceral adiposity index, smoking, the metabolic syndrome and its components (waist circumference, blood pressure, glucose and hyperlipidemia) were associated with increased serum uric acid levels and hyperuricemia (p < 0.05). Among the female HWCS participants, the odds ratio for hyperuricemia was 1.24 (95% CI, 1.01–1.53) per unit increase in soft drink consumption. As reported in other studies, our findings indicate that diet, adiposity and genetic variation contribute to the elevated prevalence of hyperuricemia in Mexico.

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Section: Discussioncontrasting

confidence: 79%

Influence of Genetic and Non-Genetic Risk Factors for Serum Uric Acid Levels and Hyperuricemia in Mexicans

et al. 2019

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“…Previous studies have shown that metabolic syndrome is associated with increased SUA levels in women, regardless of their menopausal status [31,32]. Similar findings have been reported in patients with diabetes [33], the elderly [9,32], and even in adolescents [35].…”

Section: Discussionsupporting

confidence: 81%

Measurement of the Combined Levels of Serum Uric Acid and Alanine Aminotransferase and the Risk of Metabolic Syndrome in a Population Aged 60 Years or More in Northeastern China

Wang

Chen

et al. 2020

Med Sci Monit

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Background: Serum uric acid (SUA) and alanine aminotransferase (ALT) levels are increased in patients with metabolic syndrome. This study aimed to investigate the association between the combined levels of SUA and ALT and the risk of metabolic syndrome in residents ³60 years of age in Northeastern China. Material/Methods: A population study included nine communities in Shenyang, Northeast China, and 3,998 participants (1,434 men and 2,564 women) who were ³60 years old. SUA and ALT measurements (levels 1-3) and clinical parameters were recorded. Metabolic syndrome was diagnosed according to the criteria of the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III). The association between the combined SUA and ALT levels and metabolic syndrome was determined by multivariate logistic regression analysis in tertiles that included Groups 1-9. Results: The prevalence of metabolic syndrome was 43.2% (men), and 61.9% (women), and the prevalence and odds ratio (OR) values increased with increasing SUA and ALT levels. The OR values of metabolic syndrome in the ALT Groups 2-3 were 1.329 (95% CI, 1.137-1.554) and 2.362 (95% CI, 2.006-2.781), and in the SUA Groups 2-3 the OR values were 1.718 (95% CI, 1.466-2.015) and 2.743 (95% CI, 2.310-3.256). The OR of the combined increase in SUA and ALT and metabolic syndrome in Groups 1-9 ranged from 1.494-5.889 (all, p<0.05). Conclusions: Increased combined SUA and ALT was more significantly associated with metabolic syndrome than an increase in SUA or ALT alone.

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“…According to a cross-sectional study performed by Chen JH and his colleagues [ 15 ], subjects with higher serum uric acid (sUA) levels had higher odds ratios (OR) for the occurrence of MS in the Chinese elderly aged over 65; thus, sUA levels could possibly be regarded as a potential tool for the early diagnosis of MS. In addition, a significant correlation was observed between sUA levels and MS; this association was stronger in premenopausal women than in postmenopausal women [ 16 ]. In our study, we also found that high sUA was a risk factor for MS, which supports the opinion that hyperuricemia ought to be considered a component of MS.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of metabolic syndrome in China: An up-dated cross-sectional study

Mai

Zhou

et al. 2018

PLoS ONE

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Metabolic syndrome (MS) is an increasing public health concern because of rapid lifestyle changes. Although there have been previous studies on the prevalence of MS in China, the prevalence may have changed with lifestyle changes over the last decade. To update this prevalence, we performed a cross-sectional survey among adults over 18 years old across China from May 2013 to July 2014. Participants underwent questionnaires and provided blood and urine samples for analysis. MS was defined according to the criteria of the China Diabetes Society. A total of 12570 individuals (45.2% men) with an average age of 48.8±15.3 (18–96) years were selected and invited to participate in the study. In total, 9310 (40.7% men) individuals completed the investigation, with a response rate of 74.1%. The prevalence of MS in China was 14.39% [95% confidence interval (CI): -3.75–32.53%], and the age-adjusted prevalence was 9.82% (95% CI: 9.03–10.61%; 7.78% in men and 6.76% in women; 7.39% in rural residents and 6.98% in urban residents). The highest prevalence occurred among adults aged 50–59 years (1.95%, 95% CI: 1.40–2.50%), and the lowest prevalence occurred among adults aged 40–49 years (0.74%, 95% CI: 0.38–1.10%); the prevalence was the highest in the south region and lowest in the east region (4.46% and 1.23%, respectively). The results of logistic regression analyses showed that age, urolithiasis, hyperuricemia, coronary artery disease, thiazide drugs intake, family history of diabetes and hypertension were all significantly associated with an increased risk of metabolic syndrome (OR>1). In addition, education, vitamin D intake and family history of urolithiasis are all protective factors (OR<1). Our results indicate that there was a high prevalence of MS in Chinese adults. Compared to the previous study 10 years ago, some preventive strategies have worked; however, further work on the prevention and treatment of MS remains necessary.

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The relationship between serum uric acid and metabolic syndrome in premenopausal and postmenopausal women in the Jinchang Cohort

Cited by 17 publications

References 26 publications

Influence of Genetic and Non-Genetic Risk Factors for Serum Uric Acid Levels and Hyperuricemia in Mexicans

Influence of Genetic and Non-Genetic Risk Factors for Serum Uric Acid Levels and Hyperuricemia in Mexicans

Measurement of the Combined Levels of Serum Uric Acid and Alanine Aminotransferase and the Risk of Metabolic Syndrome in a Population Aged 60 Years or More in Northeastern China

Prevalence of metabolic syndrome in China: An up-dated cross-sectional study

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