Influence of Genetic and Non-Genetic Risk Factors for Serum Uric Acid Levels and Hyperuricemia in Mexicans

Abstract

Risk of hyperuricemia is modified by genetic and environmental factors. Our aim was to identify factors associated with serum uric acid levels and hyperuricemia in Mexicans. A pilot Genome-wide association study GWAS was performed in a subgroup of participants (n = 411) from the Health Workers Cohort Study (HWCS). Single nucleotide polymorphisms (SNPs) associated with serum uric acid levels were validated in all the HWCS participants (n = 1939) and replicated in independent children (n = 1080) and adult (n = 1073) case-control studies. The meta-analysis of the whole HWCS and replication samples identified three SLC2A9 SNPs: rs1014290 (p = 2.3 × 10−64), rs3775948 (p = 8.2 × 10−64) and rs11722228 (p = 1.1 × 10−17); and an ABCG2 missense SNP, rs2231142 (p = 1.0 × 10−18). Among the non-genetic factors identified, the visceral adiposity index, smoking, the metabolic syndrome and its components (waist circumference, blood pressure, glucose and hyperlipidemia) were associated with increased serum uric acid levels and hyperuricemia (p < 0.05). Among the female HWCS participants, the odds ratio for hyperuricemia was 1.24 (95% CI, 1.01–1.53) per unit increase in soft drink consumption. As reported in other studies, our findings indicate that diet, adiposity and genetic variation contribute to the elevated prevalence of hyperuricemia in Mexico.

Metabolic syndrome and 5-year incident hyperuricemia among older Chinese adults: a community-based cohort study

“…It was in line with some studies that MetS components of high BP, high BMI, diabetes mellitus and high triglycerides at baseline were related to increased risk of HUA [20,22]. In this study, 96.6% older adults were found having abnormal BP de ned as 130/85 mmHg or greater among individuals suffered from…”

“…Moreover, increasing number of MetS components at baseline was positively related to incident HUA though the presence of only one MetS component was not a signi cant predictor. The result that baseline MetS as a risk factor for incident HUA was not unexpected and was consistent with some studies carried out in other countries [13,14,20]. A cohort study in middle-aged men in South Korea demonstrated that the incidence of HUA increased across MetS at baseline with the hazard ratio of being 1.41 [13].…”

“…A cohort study in middle-aged men in South Korea demonstrated that the incidence of HUA increased across MetS at baseline with the hazard ratio of being 1.41 [13]. In studies conducted in North American countries, MetS was reported to be associated with incident HUA both in men and women [14,20]. Moreover, a study with participants from three urban areas and one rural county of Beijing showed a 2.0-fold risk of HUA among community elderly with MetS [21], which was similar to our results.…”

High-Protein Diet Induces Hyperuricemia in a New Animal Model for Studying Human Gout

“…Hyperuricemia is the outcome of a combination of an endogenous purine metabolism disorder and an exogenous environmental disruption [37]. Recently, a trans-ancestry genome-wide association study, which included more than 450,000 individuals targeted at serum urate demonstrated that 183 loci were associated with gout [15].…”

Rapid Gout Detection Method and Kit

“…Serum urate levels are influenced by genetic and environmental factors and the interrelation between these two [3]. The elimination of milk or other dairy products due to cow milk allergies might increase the risk for gout and hyperuricemia [4].…”