The relationship between serum triglyceride level and heart rate variability in type 2 diabetes mellitus patients of North Karnataka

Balikai, Fareedabanu A; Deshpande, Neeta; Javali, Shivalingappa B; Shetty, Darshit P; Benni, Jyoti M; Shindhe, Varsha M; Jaalam, Kamaruddin; Kapoor, Nitin

doi:10.4103/jod.jod_7_20

Cited by 3 publications

(4 citation statements)

References 27 publications

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“…Hence, changes in the catecholamine response in cardiac autonomic neuropathy may be an important link explaining the association between these two clinical variables. Hypertriglyceridemia in patients with T2D is very hazardous and is negatively associated with HRV [ 59 ].…”

Section: Discussionmentioning

confidence: 99%

Association between Metabolic Syndrome Components and Cardiac Autonomic Modulation among Children and Adolescents: A Systematic Review and Meta-Analysis

Supriya

Yang

et al. 2021

Biology

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Background: the clustering of metabolic syndrome (MetS) risk factors is becoming more prevalent in children, leading to the development of type 2 diabetes (T2D) and cardiovascular diseases in early adulthood. The impact of MetS risk factors on cardiac autonomic modulation (CAM) or vice versa has been noted to track from childhood to pre-adolescence and adolescence. Understating associations in this age group may help to improve the clinical outcomes of the MetS, even when MetS symptoms are not visible. Potential damage from each individual MetS component and the ability to predict early cardiac damage or upcoming cardiovascular events is very important. Therefore, the present systematic review and meta-analysis investigated the associations between CAM and MetS risk factors individually to verify which of the MetS risk components were significantly correlated with heart rate variability (HRV) indices before or at the onset of the MetS among young people. The purpose of this review was to outline the importance of potentially screening HRV indices in young people even with only one MetS risk factor, as a pre-indicator for early cardiovascular risk stratification. Methods: cross-sectional studies that examined the relationship of MetS risk factors with HRV indices were searched using four databases including PubMed, the Cochrane clinical trials library, Medline and the Web of Science. Correlation coefficients with 95% confidence intervals (95% CI), and random effects meta-analyses of the association between MetS risk factors with HRV indices were performed. Results: out of 14 cross-sectional studies and one case-control study, 8 studies (10 data sets) provided association data for the meta-analysis. Our results indicated significant positive correlations for systolic blood pressure (SBP) (correlation coefficient 0.13 (95%CI: 0.06; 0.19), I2 = 47.26%) and diastolic blood pressure (DBP) (correlation coefficient 0.09 (95%CI: −0.01; 0.18), I2 = 0%) with a Low Frequency/High Frequency ratio (LF/HF). Significant negative correlations for waist circumference (WC) (correlation coefficient −0.12 (95%CI: −0.19; −0.04), I2 = 51.50%), Triglycerides (TGs) (correlation coefficient −0.09 (95%CI: −0.15; −0.02), I2 = 0%) and ≥2 MetS risk factors (correlation coefficient −0.10 (95%CI: −0.16; −0.03), I2 = 0%); with high frequency (HF) were revealed. Significant positive correlations for high density lipoprotein (HDL) (correlation coefficient 0.08 (95%CI: 0.05; 0.11), I2 = 0%) and significant negative correlations of ≥2 MetS risk (correlation coefficient −0.04 (95%CI: −0.12; 0.03), I2 = 0.0%) with low frequency (LF) were revealed. Significant negative correlations for TGs (correlation coefficient −0.09 (95%CI: −0.23; 0.05), I2 = 2.01%) with a mean square root of the sum of differences between mean time between two successive intervals (rMSSD) and significant positive correlation of HDL (correlation coefficient 0.09 (95%CI: −0.01; 0.19), I2 = 0.33%) with standard deviation of the time between two successive intervals (SDNN) were also revealed. An Egger’s test indicated that there was no obvious publication bias for any of the above relationships except for TGs and rMSSD. The significance level stipulated for the meta-analysis was p < 0.05. Conclusions: lipid profiles (HDL and TGs), WC and BP were associated with CAM in young people up to the age of 19 years. The use of HRV indices to predict future MetS risk, and relationships with individual risk factors including HDL, BP, WC and TGs, were established. Future studies related to young people (up to the age of 19 years) are recommended to explore the associations reported here further.

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Section: Discussionmentioning

confidence: 99%

Association between Metabolic Syndrome Components and Cardiac Autonomic Modulation among Children and Adolescents: A Systematic Review and Meta-Analysis

Supriya

Yang

et al. 2021

Biology

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“…Several clinical studies [5][6][7][8][9][10] have demonstrated that elevated blood triglyceride levels increase the risk of Type 2 Diabetes (T2D). It is well recognized that diabetes is a risk factor for cardiovascular disease and has been associated with 2-to 4-fold higher mortality [11] which is mainly due to atherogenic dyslipidemias characterized, among other factors, by elevated levels of triglycerides [12].…”

Section: Triglyceridesmentioning

confidence: 99%

“…The main step in order to reduce the risk of cardiovascular diseases related with diabetes is the detection and treatment of dyslipidemia which include the reduction of triglyceride levels. A study showed significant hypertriglyceridemia in all diabetic patients irrespective of the duration of diabetes and a significant negative correlation between triglyceride levels and heart rate variability whose reduction is related to increased mortality risk [12]. Hypertriglyceridemia has been characterized as an independent risk factor for diabetes type 2 incidence even after the control of Body Mass Index (BMI), hypertension and all other conventional risk factors [8,15,16].…”

Section: Triglyceridesmentioning

confidence: 99%

Lipidic Classes Involved in Diabetes Mellitus, Review

Trapali

2021

NRS

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Diabetes mellitus is a metabolic disorder of multiple etiology, characterized by an increase in blood sugar concentration (hyperglycemia) and impaired glucose metabolism either as a result of decreased insulin secretion or due to decreased cells sensitivity to insulin. It is classified into two broad categories that do not concern the type of treatment or age but the etiology: Type 1 diabetes (autoimmune, idiopathic) is a disorder in which pancreas does not produce enough insulin. Type 2 diabetes mellitus (disorders of insulin secretion or action) is characterized by a disturbance in the action of insulin (insulin resistance) although the pancreas may produce increased amounts of insulin. Dyslipidemia is one of the main cardiovascular risk factors in diabetic patients. These patients show a specific dyslipidemic profile which is characterized by elevated triglyceride levels, normal or mildly elevated Low-Density Lipoprotein (LDL-C) cholesterol levels and low High-Density Lipoprotein (HDL-C) cholesterol levels. This review presents the main classes of lipids involved in the pathogenesis of Diabetes mellitus, which are triglycerides, phospholipids, and steroids.

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“…Diabetes is characterized by increased triglycerides (TG), a drop in HDL, and a rise in LDL (LDL). Lipid damage in diabetes accelerates atherosclerosis (Balikai et al, 2020;Pinakesty & Azizah, 2020). Index atherogenic plasma (IAP) characteristics derived from triglyceride (TG) and high-density lipoprotein (HDL) profiles can be used to determine atherosclerosis risk.…”

Section: Introductionmentioning

confidence: 99%

Sorghum flour's effect on improving plasma lipid profile and atherogenic index in diabetic rats

Setyowati,

Muna,

Septiyani

et al. 2023

Aceh. Nutri. J.

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Dyslipidemia increases the risk of coronary heart disease in people with diabetes. Increased consumption of foods substantial in fiber and antioxidants, such as sorghum, can help people with diabetes manage their lipid profiles and improve insulin sensitivity. The study aimed to evaluate how sorghum flour affected diabetic rats' plasma atherosclerosis index (IAP) score and blood lipid profile. A randomized control design was used for the research's experimental methodology. In 2019, the study was carried out at P3G Laboratory UGM. 18 male Wistar rats served as the subjects and were separated into three groups: treatment (P) (5 g/mouse/day for 28 days), positive control (K+), and negative control of sorghum flour (K-). By administering nicotinamide and streptozotocin (STZ), the DM rat model was created (NA). The GPO-PAP method was used to measure TG levels. Total cholesterol, low-density lipoprotein, and high-density lipoprotein were all measured using CHOD-PAP. The log (TG/HDL) ratio (IAP) calculated the plasma atherosclerosis index. Paired T-tests, Wilcoxon, Anova, and Kruskal-Wallis, were used to evaluate the data. According to the findings, there were significant changes in the groups' baseline and post-intervention levels of total cholesterol (p=0,003), triglycerides (p=0,002), low-density lipoprotein (p=0,003), high-density lipoprotein (p=0,002), and IAP (p=0,001). In conclusion, feeding DM rats sorghum flour altered their blood lipid levels and plasma atherosclerosis index (IAP). Their LDL, triglycerides, and total cholesterol can all be reduced with a daily intake of 5 g per person.

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The relationship between serum triglyceride level and heart rate variability in type 2 diabetes mellitus patients of North Karnataka

Cited by 3 publications

References 27 publications

Association between Metabolic Syndrome Components and Cardiac Autonomic Modulation among Children and Adolescents: A Systematic Review and Meta-Analysis

Association between Metabolic Syndrome Components and Cardiac Autonomic Modulation among Children and Adolescents: A Systematic Review and Meta-Analysis

Lipidic Classes Involved in Diabetes Mellitus, Review

Sorghum flour's effect on improving plasma lipid profile and atherogenic index in diabetic rats

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