The Relationship Between Serum Concentration of Vitamin D, Total Intracranial Volume, and Severity of Depressive Symptoms in Patients With Major Depressive Disorder

Zhu, Daomin; Zhao, Wenming; Zhang, Biao; Yang, Ying; Zhang, Cun; Wang, Yajun; Zhu, Jiajia; Yu, Yongqiang

doi:10.3389/fpsyt.2019.00322

Cited by 25 publications

(24 citation statements)

References 51 publications

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“…A vast number of studies on the association between serum 25 (OH)D concentration and depressive symptoms have been conducted, and although there have been some negative results, numerous number of studies have shown positive results (6,7). However, whether there are sex differences regarding this association is still controversial.…”

Section: Introductionmentioning

confidence: 99%

Serum Vitamin D Concentrations Are Associated With Depressive Symptoms in Men: The Sixth Korea National Health and Nutrition Examination Survey 2014

2020

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Objective: There is increasing evidence of an inverse association between serum vitamin D concentrations and depression, but whether there are sex-specific differences remains controversial. Thus, the aim of this study was to investigate the association between serum vitamin D concentrations and specific domains of depressive symptoms by each sex in the Korean general population. Methods: The study sample comprised 820 men and 916 women, aged from 19 to 76, who participated in the Korea National Health and Nutrition Examination Survey 2014. Participants completed health interviews and health examinations providing data of serum 25-hydroxyvitamin [25(OH)D] concentrations, the Patient Health Questionnaire-9 (PHQ-9), and certain covariates. Associations were analyzed using negative binomial regression. Results: After adjusting for various covariates, the association between log-transformed serum 25(OH)D concentrations and total PHQ-9 scores was statistically significant {incidence rate ratio [IRR] = 0.74 [95% confidence interval (CI) = 0.59-0.93]} only in men. Additionally, the association between log-transformed serum 25(OH)D concentrations and the PHQ-9 cognitive/affective subscore was statistically significant [IRR = 0.56 (95% CI = 0.40-0.80)] only in men. There was no association for the somatic subscore. Conclusions: Serum vitamin D levels were inversely associated with cognitive/affective depressive symptoms only in men.

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Section: Introductionmentioning

confidence: 99%

Serum Vitamin D Concentrations Are Associated With Depressive Symptoms in Men: The Sixth Korea National Health and Nutrition Examination Survey 2014

2020

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“…Many studies have suggested that psychiatric disorders, such as schizophrenia, alcoholism, and depression, may be associated with low serum levels of 25hydroxyvitamin D, 25(OH)D [7][8][9][10][11][12][13]. Recent studies report that vitamin D deficiency may be associated with an increase in depression rates from 8 to 14% [14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Contributions of vitamin D in the management of depressive symptoms and cardiovascular risk factors: study protocol for a randomized, double-blind, placebo-controlled clinical trial

Porto

Silva

Sougey

2019

Trials

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AbstratofundoA depressão é uma das principais causas de incapacidade crônica em todo o mundo e um importante fator de risco cardiovascular, aumentando o risco relativo de doença arterial coronariana, bem como as taxas de morbimortalidade cardiovascular. Concomitantemente à alta prevalência de depressão, houve uma redução na exposição à luz solar com o aumento da urbanização e do uso de protetores solares, o que levou a uma redução nos níveis séricos de 25-hidroxivitamina D. Portanto, este artigo descreve uma protocolo para um ensaio clínico com o objetivo de avaliar os efeitos da suplementação de vitamina D na depressão e fatores de risco cardiovascular para contribuir com evidências sobre a influência potencial da suplementação na regulação do humor.MétodosEste estudo de protocolo foi orientado pelos itens de protocolo padrão: recomendações para ensaios intervencionistas. Um ensaio clínico randomizado, controlado por placebo, duplo-cego será realizado envolvendo 224 adultos (faixa etária de 18 a 60 anos) com depressão que estão tomando antidepressivos e não têm histórico de suplementação de vitamina D, comorbidades psiquiátricas, doença renal crônica, hipercalcemia, ou neoplasia. Os participantes serão recrutados nos ambulatórios psiquiátricos de duas universidades do nordeste do Brasil. Os participantes elegíveis que fornecerem consentimento por escrito serão designados aleatoriamente para o grupo de intervenção (n = 112; suplementação de vitamina D 50.000 UI por semana durante 6 meses) ou para o grupo controle (n = 112; placebo tomado semanalmente por 6 meses). Medidas para monitorar sintomas depressivos, exames clínicos e exames laboratoriais para avaliar fatores de risco cardiovascular e níveis séricos de vitamina D serão realizadas antes e após o período de intervenção.DiscussãoAté onde sabemos, este será o primeiro ensaio clínico com o objetivo de testar a eficácia da suplementação de vitamina D na redução do risco cardiovascular e como um adjuvante à terapia da depressão por um período prolongado (6 meses). Os resultados contribuirão para a compreensão dos efeitos terapêuticos da suplementação de vitamina D no tratamento da depressão e podem ajudar a orientar políticas públicas direcionadas à suplementação de vitamina para a redução do risco cardiovascular.Registro de testeRegistro Brasileiro de Ensaios Clínicos, RBR-6yj8sj/ Número Universal de Ensaios (UTN) U1111-1217-9237. Registrado em 23 de julho de 2018.

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“…Moreover, a negative correlation was observed in relation to total intracranial volume (TIV). TIV itself showed a positive correlation with vitamin D levels in patients with MDD [20].…”

Section: Depressionmentioning

confidence: 86%

The effect of vitamin D on mental health – literature analysis

Kozyra¹,

Zimnicki²,

Kaczerska³

et al. 2020

J Educ Health Sport

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Introduction: Many sources list a number of properties of vitamin D on human health. It seems that the benefits of using this vitamin include not only the regulation of the calcium-phosphate metabolism, but also a number of other applications, also in human mental health. The aim of the study: The aim of the study was to research about the influence of vitamin D on the mental health. The research was done on the problems such as depression, anxiety, psychoses, stress, mood and emotions. Material and method: The literature was found using websites such as PubMed or Google Scholar was used to develop this work. Description of the state of knowledge: A number of studies have confirmed that vitamin D can have a significant impact on reducing the level of depression. One example of a study on this topic is that high vitamin D supplementation in women in early pregnancy can protect them from late depression during the last weeks of pregnancy. Likewise, adequate vitamin D supplementation in older people can improve mental health and reduce the likelihood of depression and Seasonal Mood Disorder (SAD). In addition, vitamin D can reduce the probability of psychosis or anxiety disorders. Summary: Many sources report a positive correlation between vitamin D supply and mental health. Often the differences are also noticeable, but not statistically significant. This work sometimes shows divergent views of scientists, which is important to continue research into the effects of vitamin D on mental health in humans.

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The Relationship Between Serum Concentration of Vitamin D, Total Intracranial Volume, and Severity of Depressive Symptoms in Patients With Major Depressive Disorder

Cited by 25 publications

References 51 publications

Serum Vitamin D Concentrations Are Associated With Depressive Symptoms in Men: The Sixth Korea National Health and Nutrition Examination Survey 2014

Serum Vitamin D Concentrations Are Associated With Depressive Symptoms in Men: The Sixth Korea National Health and Nutrition Examination Survey 2014

Contributions of vitamin D in the management of depressive symptoms and cardiovascular risk factors: study protocol for a randomized, double-blind, placebo-controlled clinical trial

The effect of vitamin D on mental health – literature analysis

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