The Relationship Between Premature Ejaculation and Hyperthyroidism

Cíhan, Ahmet; Demir, Ömer; Demir, Tevfik; Aslan, Güven; Çömlekçi, Abdurrahman; Esen, Ahmet Adil

doi:10.1016/s0022-5347(08)60882-4

Cited by 30 publications

(55 citation statements)

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“…This study supports the conclusions of the two previous studies investigating the association between dysthyroidism and ED. The pioneering study investigating the relationship between dysthyroidism and ED was a multi-center study conducted in Italy, 4 which analyzed the sexual function, including ED, among 34 men with hyperthyroidism and 14 with hypothyroidism. Upon presentation with dysthyroidism, they screened each subject for hypoactive sexual desire, ED, premature ejaculation and delayed ejaculation.…”

Section: Resultsmentioning

confidence: 99%

“…In addition to improvements in premature ejaculation, delayed ejaculation and ejaculation latency time, there were significant changes among subdomains of IIEF. 4 The second investigation was performed on 71 men and a similar number of controls selected from one thyroid outpatient hospital in Greece. Of the cases, 27 had hyperthyroidism and 44 had hypothyroidism.…”

Section: Resultsmentioning

confidence: 99%

“…As previous work demonstrated that the restoration of euthyroidism recovered sexual function, 13,4 it is the suggestion of the authors that clinicians follow the advice of previous studies and not begin treatment for ED among hyperthyroid patients until after first completing 6 months of treatment for hyperthyroidism and the restoration of euthyroidism. Furthermore, it is suggested that patients with long-standing hyperthyroidism complaining of ED first be questioned regarding their adherence to their hyperthyroid treatment regimen and have their thyroid levels checked before proceeding to treatment for ED.…”

Section: Resultsmentioning

confidence: 99%

“…Whether on account of autoimmune, inflammatory or metabolic sources, 1 the effects of hyperthyroidism have been reported to be associated with sexual impotence among men. 3,4 Furthermore, one recent study has demonstrated that thyroid hormone nuclear receptors in the penis provide the biological basis for the direct action of thyroid hormones on this organ and suggested that physicians should be advised to investigate sexual function in men with thyroid disorders. 5 Erectile dysfunction (ED) is defined as the inability to achieve or maintain an erection sufficient for satisfactory sexual intercourse and is the most common sexual problem among aging male subjects.…”

Section: Introductionmentioning

confidence: 99%

“…12 To date, few studies have investigated the association between dysthyroidism and ED, and all were either hospital-based studies or characterized by small case numbers. The pioneering study was conducted in Italy and included 34 men in a multicenter study in Italy, 4 while another study included 27 individuals suffering from hyperthyroidism selected from the thyroid outpatient clinic of one hospital in Greece. 13 …”

Section: Introductionmentioning

confidence: 99%

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Hyperthyroidism and erectile dysfunction: a population-based case—control study

2012

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Dysthyroidism has been highlighted as a common endocrine disorder associated with erectile dysfunction (ED); however, to date, no large-scale population-based study has investigated the association between hyperthyroidism and ED. This case--control study aimed to explore the association between ED and hyperthyroidism using a population-based data set. In total, 6310 adult patients who received new diagnoses of ED were recruited as cases together with 18 930 matched enrollees with no history of ED who served as controls. Conditional logistic regressions were conducted to explore the association between ED and having been previously diagnosed with hyperthyroidism. In total, 569 (2.3%) of the 25 240 sampled subjects had been diagnosed with hyperthyroidism before the index date; hyperthyroidism was found in 207 (3.3%) cases and 362 (1.90%) controls. After adjusting for potential confounding factors, the odds ratio (OR) of prior hyperthyroidism among cases was 1.64 (95% confidence interval ¼ 1.37--1.96, Po0.001) than that of controls. No association was detected between prior hyperthyroidism and ED for the 18--30, 30--39 and X70 age groups. Subjects aged between 60 and 69 years had the highest ORs for prior hyperthyroidism among cases when compared to controls (OR ¼ 1.84; 95% confidence interval ¼ 1.20--2.84; Po0.001). Our study further confirms the existence of an association between ED and prior hyperthyroidism. INTRODUCTIONHyperthyroidism is a condition in which the thyroid produces an excessive amount of thyroid hormone 1 and affects approximately 2% of women, but significantly less in men. 2 A recently conducted prevalence study in Norway found that 0.9% of all Norwegian men over 20 years old in Nord-Trù ndelag had been diagnosed with hyperthyroidism. 3 Graves' disease accounts for 70% of hyperthyroidism cases, with the age of onset most often occurring during young adulthood 1 and is a genetically linked autoimmune disorder in which the body produces antibodies to its own tissues, which in turn cause the thyroid to produce excess of thyroid hormone. The other 30% of hyperthyroidism cases result from other causes, such as toxic nodular goiters, subacute thyroiditis, exposure to iodine from medications or X-ray dyes and postpartum thyroiditis. Whether on account of autoimmune, inflammatory or metabolic sources, 1 the effects of hyperthyroidism have been reported to be associated with sexual impotence among men. 3,4 Furthermore, one recent study has demonstrated that thyroid hormone nuclear receptors in the penis provide the biological basis for the direct action of thyroid hormones on this organ and suggested that physicians should be advised to investigate sexual function in men with thyroid disorders. 5 Erectile dysfunction (ED) is defined as the inability to achieve or maintain an erection sufficient for satisfactory sexual intercourse and is the most common sexual problem among aging male subjects. 6,7 The Massachusetts Male Aging Study reported that 52% of their community-based survey of men aged between 40...

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hyperthyroidism and erectile dysfunction: a population-based case—control study

2012

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An Update of the International Society of Sexual Medicine's Guidelines for the Diagnosis and Treatment of Premature Ejaculation (PE)

et al. 2014

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IntroductionIn 2009, the International Society for Sexual Medicine (ISSM) convened a select panel of experts to develop an evidence-based set of guidelines for patients suffering from lifelong premature ejaculation (PE). That document reviewed definitions, etiology, impact on the patient and partner, assessment, and pharmacological, psychological, and combined treatments. It concluded by recognizing the continually evolving nature of clinical research and recommended a subsequent guideline review and revision every fourth year. Consistent with that recommendation, the ISSM organized a second multidisciplinary panel of experts in April 2013, which met for 2 days in Bangalore, India. This manuscript updates the previous guidelines and reports on the recommendations of the panel of experts.AimThe aim of this study was to develop clearly worded, practical, evidenced-based recommendations for the diagnosis and treatment of PE for family practice clinicians as well as sexual medicine experts.MethodA comprehensive literature review was performed.ResultsThis article contains the report of the second ISSM PE Guidelines Committee. It offers a new unified definition of PE and updates the previous treatment recommendations. Brief assessment procedures are delineated, and validated diagnostic and treatment questionnaires are reviewed. Finally, the best practices treatment recommendations are presented to guide clinicians, both familiar and unfamiliar with PE, in facilitating treatment of their patients.ConclusionDevelopment of guidelines is an evolutionary process that continually reviews data and incorporates the best new research. We expect that ongoing research will lead to a more complete understanding of the pathophysiology as well as new efficacious and safe treatments for this sexual dysfunction. We again recommend that these guidelines be reevaluated and updated by the ISSM in 4 years. Althof SE, McMahon CG, Waldinger MD, Serefoglu EC, Shindel AW, Adaikan PG, Becher E, Dean J, Giuliano F, Hellstrom WJG, Giraldi A, Glina S, Incrocci L, Jannini E, McCabe M, Parish S, Rowland D, Segraves RT, Sharlip I, and Torres LO. An update of the International Society of Sexual Medicine's guidelines for the diagnosis and treatment of premature ejaculation (PE). Sex Med 2014;2:60–90.

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Associations between Salivary Testosterone Levels, Androgen-Related Genetic Polymorphisms, and Self-Estimated Ejaculation Latency Time

et al. 2014

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IntroductionRecently, testosterone (T) has been shown to be associated with premature ejaculation (PE) symptoms in the literature. Furthermore, studies suggest that the etiology of PE is partly under genetic control.AimThe aim of this study was to reassess findings suggesting an association between testosterone (T) and a key symptom of PE, ejaculation latency time (ELT), as well as exploratively investigating associations between six androgen-related genetic polymorphisms and ELT.Materials and MethodsStatistical analyses were performed on a population-based sample of 1,429 Finnish men aged 18–45 years (M = 26.9, SD = 4.7). Genotype information was available for 1,345–1,429 of these (depending on the polymorphism), and salivary T samples were available from 384 men. Two androgen receptor gene-linked, two 5-alpha-reductase type 2-gene-linked, and two sex hormone-binding globuline gene-linked polymorphisms were genotyped.Main Outcome MeasuresEjaculatory function was assessed using self-reported ELT.ResultsWe found no association between salivary T levels and ELT. We found a nominally significant association between a 5-alpha-reductase type 2-gene-linked polymorphism (rs2208532) and ELT, but this association did not remain significant after correction for multiple testing. One single nucleotide polymorphism in the sex hormone-binding globulin gene (rs1799941) moderated (significantly after correction for multiple testing) the association between salivary T and ELT, so that A:A genotype carriers had significantly lower salivary T levels as a function of increasing ELT compared with other genotype groups.ConclusionsWe were unable to find support for the hypothesis suggesting an association between T levels and ELT, possibly because of the low number of phenotypically extreme cases (the sample used in the present study was population based). Our results concerning genetic associations should be interpreted with caution until replication studies have been conducted. Jern P, Westberg L, Ankarberg-Lindgren C, Johansson A, Gunst A, Sandnabba NK, and Santtila P. Associations between salivary testosterone levels, androgen-related genetic polymorphisms, and self-estimated ejaculation latency time. Sex Med 2014;2:107–114.

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The Relationship Between Premature Ejaculation and Hyperthyroidism

Cited by 30 publications

References 0 publications

Hyperthyroidism and erectile dysfunction: a population-based case—control study

Hyperthyroidism and erectile dysfunction: a population-based case—control study

An Update of the International Society of Sexual Medicine's Guidelines for the Diagnosis and Treatment of Premature Ejaculation (PE)

Associations between Salivary Testosterone Levels, Androgen-Related Genetic Polymorphisms, and Self-Estimated Ejaculation Latency Time

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