Introduction: Sexual dysfunction affects many people, with 33-60% of women reporting sexual dysfunction and 8-52% of men with erectile dysfunction (ED) or premature ejaculation (PE). In an effort to determine the constellation of factors responsible for sexual dysfunction, the effect of thyroid hormone derangements has been of recent interest. Aim: To investigate the associations between thyroid hormones and sexual dysfunction in women and men. Methods: Review of the literature examining effects of hypo-and hyperthyroidism on sexual function. Main Outcome Measures: Summary of effects of thyroid dysfunction on domains of sexual functioning. Results: Most studies demonstrate that hypothyroid and hyperthyroid men have increased rates of sexual dysfunction, including erectile dysfunction (ED) in hypothyroid men. However, studies vary on the strength of correlation between hormonal derangement and level of sexual dysfunction. In both hyper-and hypothyroid men, treatment of thyroid disorder at least partially reverses sexual dysfunction. In contrast, the current literature provides no consensus on the effect of hypothyroidism, hyperthyroidism, or Hashimoto's thyroiditis on female sexual function. In studies that observed increased rates of sexual dysfunction in women with thyroid disorders, correction of the thyroid derangement resulted in resolution of some sexual dysfunction. Studies are also conflicted on whether there is a relationship between degree of sexual dysfunction and degree of hormone derangement in women. However, prior work has demonstrated a relationship between thyroid autoantibodies and sexual dysfunction in women.