Dysthyroidism has been highlighted as a common endocrine disorder associated with erectile dysfunction (ED); however, to date, no large-scale population-based study has investigated the association between hyperthyroidism and ED. This case--control study aimed to explore the association between ED and hyperthyroidism using a population-based data set. In total, 6310 adult patients who received new diagnoses of ED were recruited as cases together with 18 930 matched enrollees with no history of ED who served as controls. Conditional logistic regressions were conducted to explore the association between ED and having been previously diagnosed with hyperthyroidism. In total, 569 (2.3%) of the 25 240 sampled subjects had been diagnosed with hyperthyroidism before the index date; hyperthyroidism was found in 207 (3.3%) cases and 362 (1.90%) controls. After adjusting for potential confounding factors, the odds ratio (OR) of prior hyperthyroidism among cases was 1.64 (95% confidence interval ¼ 1.37--1.96, Po0.001) than that of controls. No association was detected between prior hyperthyroidism and ED for the 18--30, 30--39 and X70 age groups. Subjects aged between 60 and 69 years had the highest ORs for prior hyperthyroidism among cases when compared to controls (OR ¼ 1.84; 95% confidence interval ¼ 1.20--2.84; Po0.001). Our study further confirms the existence of an association between ED and prior hyperthyroidism. INTRODUCTIONHyperthyroidism is a condition in which the thyroid produces an excessive amount of thyroid hormone 1 and affects approximately 2% of women, but significantly less in men. 2 A recently conducted prevalence study in Norway found that 0.9% of all Norwegian men over 20 years old in Nord-Trù ndelag had been diagnosed with hyperthyroidism. 3 Graves' disease accounts for 70% of hyperthyroidism cases, with the age of onset most often occurring during young adulthood 1 and is a genetically linked autoimmune disorder in which the body produces antibodies to its own tissues, which in turn cause the thyroid to produce excess of thyroid hormone. The other 30% of hyperthyroidism cases result from other causes, such as toxic nodular goiters, subacute thyroiditis, exposure to iodine from medications or X-ray dyes and postpartum thyroiditis. Whether on account of autoimmune, inflammatory or metabolic sources, 1 the effects of hyperthyroidism have been reported to be associated with sexual impotence among men. 3,4 Furthermore, one recent study has demonstrated that thyroid hormone nuclear receptors in the penis provide the biological basis for the direct action of thyroid hormones on this organ and suggested that physicians should be advised to investigate sexual function in men with thyroid disorders. 5 Erectile dysfunction (ED) is defined as the inability to achieve or maintain an erection sufficient for satisfactory sexual intercourse and is the most common sexual problem among aging male subjects. 6,7 The Massachusetts Male Aging Study reported that 52% of their community-based survey of men aged between 40...
Even though a growing number of studies have found that patients with ankylosing spondylitis (AS) suffer from sexual problems, only very few studies have specifically addressed the relationship between AS and ED. Using a population-based data set, this case-control study aimed to examine the association of ED with a prior diagnosis of AS in Taiwan. We selected 2213 ED patients ≥40 years old and 17,704 matched controls. We considered the date of the first diagnosis of ED as the index date for cases. Multivariate logistic regression was performed to calculate the odds ratio (OR) and corresponding 95% confidence interval (CI) for the association between previously diagnosed AS and ED. A total of 224 out of the 19,917 sampled subjects (1.1%) had been diagnosed with AS before the index date. Prior AS was found in 42 (1.9%) cases and 182 (1.0%) controls. After adjusting for geographic location, urbanization level, hypertension, diabetes, coronary heart disease, hyperlipidemia, obesity, depressive disorder and alcohol abuse/alcohol-dependence syndrome, multivariate logistic regression revealed that cases were more likely to have been previously diagnosed with AS than controls (OR=1.58, 95% CI=1.09-2.19, P=0.019). There was an association between ED and AS. We suggest that physicians should be attentive to sexual complaints from AS patients in order to refer them to other specialists for multidisciplinary management.
Purpose The purpose of this study was to investigate the incidence of peripherally inserted central catheter-related venous thrombosis (PICC-RVT) in cancer patients with different indwelling times after PICC catheterization, and to explore the main factors related to PICC-RVT in cancer patients. Methods A retrospective study of a total of 654 cancer patients who underwent PICC insertion was conducted from January 2020 to December 2021 in a tertiary hospital in Guangdong Province, China. The risk factors for PICC-RVT in cancer patients were analyzed by logistic regression, including the clinical symptoms of the patients and the monitoring of asymptomatic thrombosis in combination with color Doppler ultrasonography. Results The incidence of PICC-RVT in cancer patients reached 24.9% (n = 163), among which the incidence of thrombosis at 1 month, 3 months, and 6 months and more was 30.6% (n = 11), 25.5% (n = 37) and 18.89% (n = 115), respectively. Multivariable analysis identified 6 variables: "age", "sex", "BMI", “with or without chemotherapy ", "different catheter indwelling duration" and "different cancer types". We observed a trend for a higher risk of PICC-RVT in cancer patients who were male (OR = 1.46, P = 0.035), were older than 69 years (OR = 1.76, P = 0.08), had a BMI < 18.5 (OR = 0.47, P = 0.015), and did not undergo chemotherapy (OR = 0.52, P = 0.048), which were determined to be independent influencing factors for PICC-RVT in cancer patients. Conclusion PICCs had a high incidence of thrombosis in the early indwelling period. The results suggest that patients with cancer who are male, elderly, emaciated, and not receiving chemotherapy should be monitored and treated to prevent PICC-RVT.
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