The relationship between potency of oxidative stress and severity of depression

Abstract

The patients with major depression are exposed to oxidative stress, and OSI may be useful to reflect the severity of the disease.

Clinical correlation of alteration of endogenous antioxidant-uric acid level in major depressive disorder

“…Our findings are in consistent with most of the previous reports on serum uric acid in major depression (8,10). The different mechanisms have been proposed for action of uric acid as an antioxidant Uric acid spares ascorbic acid by changing its electron content (6).…”

“…Uric acid is a potent endogenous antioxidant in the body (6). As per our knowledge and recent internet search although alteration in the uric acid in MDD are reported (8,10), no study has ever been reported the alteration of uric acid after SSRIs in particularly fluoxetine and citalopram treatment. Lack of conclusive information regarding the potential of such biochemical variable like uric acid as supportive prognostic indicator or predictor of treatment response in MDD has encouraged us to analyze changes induced by SSRIs on serum uric acid level in MDD.…”

“…The non enzymatic antioxidant levels are also modified in major depression. Accumulating evidence suggest lowering of these antioxidants in patients of major depression (8,9,10). SSRIs also modify some of the non enzymatic antioxidant levels (11,12).…”

Total oxidant and antioxidant capacities, nitric oxide and malondialdehyde levels in cats seropositive for the feline coronavirus

“…Oxidative stress is a secondary aggravating factor in most diseases. Furthermore, an important degree of negative correlation between total antioxidant capacity (TAC) and total oxidant capacity (TOC) in animals suffering from diseases that cause oxidative stress has been reported (Yanik et al 2004). Oxidative defence mechanisms against ROS, although activated, might not be efficient enough and clinical symptoms of illness may occur (Gutteridge 1993).…”

Effect of Ascorbic Acid on Mental Depression Drug Therapy: Clinical Study

“…Another pediatric double-blind placebo-controlled study [3,4] has shown efficacy of hider does off ascorbic acid (1000 mg per day) supplementation with an average dose of fluoxetine (10-20 mg per day). The fluoxetine ascorbic acid combination showed a significant decrease in depressive symptoms in comparison to fluoxetine plus placebo group as measured by the CDRS.…”