Total oxidant and antioxidant capacities, nitric oxide and malondialdehyde levels in cats seropositive for the feline coronavirus

Abstract

Feline coronavirus (FCoV) is a highly contagious virus that is ubiquitous in multicat environments and may induce oxidative stress. This virus commonly causes an asymptomatic infection, which can persist in certain individuals. Sporadically and unpredictably, FCoV infection leads to feline infectious peritonitis (FIP), a highly fatal systemic immune-mediated disease. There are no data in the veterinary literature relating to oxidative stress in FCoV. Antioxidant capacity (TAC) can be attributed to single components in the defence systems against free radicals. The measurement of the total oxidant status (TOS) accurately reflects the oxidative status of blood plasma or serum. Nitric oxide (NO) acts as a free radical and contributes to host defences against oxidation. Malondialdehyde (MDA) is a reliable and commonly used marker of overall lipid peroxidation levels and the presence of oxidative stress. This study aimed to determine levels of oxidative stress markers, serum TAC, total oxidant capacity (TOC), NO and serum MDA in 24 cats seropositive for FCoVs and 15 cats seronegative for FCoVs. Significantly higher serum TOC, NO and MDA levels were found in seropositive animals (P < 0.001, P < 0.05 and P < 0.001, respectively) than in seronegative animals. In contrast, serum TAC levels were found to be significantly lower in seropositive cats compared with seronegative cats (P < 0.001). The results of the present study suggest that FCoV seropositivity is associated with oxidative stress and decreased antioxidant status.

Partial replacement of dietary buffalo meat on the bone with chicken carcass improves serum antioxidant profile of zoo‐housed Indian leopards (Panthera pardus fusca)

“…Very few studies report values of these parameters in felids. Serum concentrations of TAC ranged from 1.29 to 2.21 mmol/L (Krofič et al, ; Kayar et al, ) in domestic cats and from 0.93 to 1.27 mmol/L in dogs (Nemec et al, ). Serum concentration of SOD ranged from 56 to 80 U/ml in cats (Webb, Lehman, & McCord, ).…”

“…Although SOD and catalase are important antioxidant enzymes, TAC indicates the antioxidant profile of the system as a whole (Sies, 2007]. Superoxide anion or free radicals generated during enzymatic and nonenzymatic reactions in the cell, are dismutated by SOD to (Krofič et al, 2014;Kayar et al, 2015) in domestic cats and from 0.93 to 1.27 mmol/L in dogs (Nemec et al, 2000). Serum concentration of SOD ranged from 56 to 80 U/ml in cats (Webb, Lehman, & McCord, 2008).…”

Amelioration of oxidative stress using N‐acetylcysteine in canine parvoviral enteritis

“…The oxidant/antioxidant imbalance has been reported in pathogenesis of enteric viral diseases like feline coronavirus, bovine herpesvirus‐1, porcine reproductive and respiratory syndrome and rotavirus (De et al., ; Durgut, Ataseven, & Öztürk, ; Kayar et al., ; Stukelj, Toplak, & Nemec Svete, ). Recently, it has been observed that parvovirus infection is linked with oxidative stress, and marked enhancement of reactive oxygen/nitrogen species, lipid peroxidation, DNA damage and poor antioxidant reserve (Luo & Qiu, ; Nykky, Vuento, & Gilbert, ; Panda, Patra, Nandi, & Swarup, ).…”

Effects of Safranal on Tissue Oxidative Stress in Sub-Chronic Thinner-Addicted Rats

“…It was reported that the antioxidant/oxidant status in the body was more simply evaluated by TAS and TOS measurements and gave an insight about the sensitive balance between the in vivo oxidants and antioxidants as a result of synergistic interactions (Ghiselli et al, 2000;Erel, 2004;Erel, 2005;Kayar et al, 2015). However, once the antioxidant/oxidant balance was deteriorated in favor of oxidants and oxidative stress occurred, a significant negative correlation could be observed between the TAS and TOS levels (Erel, 2005).…”