Clinical correlation of alteration of endogenous antioxidant-uric acid level in major depressive disorder

Chaudhari, Kiran; Khanzode, Suchet D.; Dakhale, Ganesh N.; Saoji, Anand; Sarode, Sarika

doi:10.1007/s12291-010-0016-z

Cited by 52 publications

(34 citation statements)

References 13 publications

(16 reference statements)

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“…Plasma uric acid was significantly decreased in depressive rats, which was consistent with most reports in major depressive patients (Chaudhari et al 2010). Uric acid is an important non-enzymatic antioxidant.…”

Section: Biochemical Alterations In Cums-induced Depression Model In supporting

confidence: 91%

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An 1H NMR and UPLC–MS-based plasma metabonomic study to investigate the biochemical changes in chronic unpredictable mild stress model of depression

Zheng

Zhang

et al. 2010

Metabolomics

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Depression is a common and highly debilitating psychiatric illness. However, the pathophysiology of depression is not fully understood. In this study SpragueDawley rats were exposed to chronic unpredictable mild stress (CUMS) to induce depression. A metabonomic study on plasma of CUMS-induced depressive rats was performed to research the pathologic mechanism of depression by using 1 H nuclear magnetic resonance (NMR) spectroscopy and ultra performance liquid chromatography coupled to mass spectrometry (UPLC-MS). Clear separations between depressive rats and control rats were observed by principal component analysis (PCA) based on the data obtained using both analytical techniques and 18 significantly changed metabolites were identified as potential biomarkers of depression. Depressive rats were characterized by altered levels of plasma lysophosphatidylcholines, amino acids, cholic acid, choline, lactate, glycoproteins, glucose, ketone bodies, nucleosides and gut microflora metabolites, which were related to multiple perturbed metabolic pathways and contributed to the elucidation of the complex mechanism of depression. To the best of our knowledge, this is the first plasma metabonomic study on CUMS-induced depressive rats by using two complementary analytical technologies. Our results showed that metabonomic approach offers a useful tool to identify depression-specific biomarkers and provide new insights into the pathophysiology of depression.

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Section: Biochemical Alterations In Cums-induced Depression Model In supporting

confidence: 91%

“…A recent WHO report predicts that depression will be the second most important cause of disability and premature death by 2020 (Chaudhari et al 2010). However, the pathophysiology of depression is not completely understood.…”

Section: Introductionmentioning

confidence: 99%

An 1H NMR and UPLC–MS-based plasma metabonomic study to investigate the biochemical changes in chronic unpredictable mild stress model of depression

Zheng

Zhang

et al. 2010

Metabolomics

View full text Add to dashboard Cite

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“…Uric acid, as one of a cluster of urinary metabolites, was correlated with first depressive episode in drug-naïve MDD subjects (Zheng et al, 2013). Another study compared healthy controls and MDD patients and found that lower levels of uric acid were associated with MDD (Chaudhari et al, 2010); indeed, the authors noted a strong inverse relation between Hamilton Depression Rating Scale (HDRS) scores and uric acid levels after 12 weeks of antidepressant treatment (Chaudhari et al, 2010). Interestingly, in another study, subjects with MDD showed lower plasma uric acid levels than healthy controls and BD patients (Kesebir et al, 2014).…”

Section: Human Studiesmentioning

confidence: 99%

Purinergic system dysfunction in mood disorders: a key target for developing improved therapeutics

Ortiz

Ulrich

Zarate

et al. 2015

Progress in Neuro-Psychopharmacology and Biological Psychiatry

104

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Uric acid and purines (such as adenosine) regulate mood, sleep, activity, appetite, cognition, memory, convulsive threshold, social interaction, drive, and impulsivity. A link between purinergic dysfunction and mood disorders was first proposed a century ago. Interestingly, a recent nationwide population-based study showed elevated risk of gout in subjects with bipolar disorder (BD), and a recent meta-analysis and systematic review of placebo-controlled trials of adjuvant purinergic modulators confirmed their benefits in bipolar mania. Uric acid may modulate energy and activity levels, with higher levels associated with higher energy and BD spectrum. Several recent genetic studies suggest that the purinergic system particularly the modulation of P1 and P2 receptor subtypes—plays a role in mood disorders, lending credence to this model. Nucleotide concentrations can be measured using brain spectroscopy, and ligands for in vivo positron emission tomography (PET) imaging of adenosine (P1) receptors have been developed, thus allowing potential target engagement studies. This review discusses the key role of the purinergic system in the pathophysiology of mood disorders. Focusing on this promising therapeutic target may lead to the development of therapies with antidepressant, mood stabilization, and cognitive effects.

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“…Though studies examining the role of SUA in affective disorders like major depressive disorder (MDD) and anxiety disorders are scant, the available evidence suggests a protective role of SUA in both depression [7], [8], [9] and anxiety [10]. The exact pathophysiologic mechanism linking SUA to these disease states is still unclear.…”

Section: Introductionmentioning

confidence: 99%

Associations of Serum Uric Acid and SLC2A9 Variant with Depressive and Anxiety Disorders: A Population-Based Study

et al. 2013

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BackgroundLimited information exists regarding the association between serum uric acid (SUA) and psychiatric disorders. We explored the relationship between SUA and subtypes of major depressive disorder (MDD) and specific anxiety disorders. Additionally, we examined the association of SLC2A9 rs6855911 variant with anxiety disorders.MethodsWe conducted a cross-sectional analysis on 3,716 individuals aged 35–66 years previously selected for the population-based CoLaus survey and who agreed to undergo further psychiatric evaluation. SUA was measured using uricase-PAP method. The French translation of the semi-structured Diagnostic Interview for Genetic Studies was used to establish lifetime and current diagnoses of depression and anxiety disorders according to the DSM-IV criteria.ResultsMen reported significantly higher levels of SUA compared to women (357±74 µmol/L vs. 263±64 µmol/L). The prevalence of lifetime and current MDD was 44% and 18% respectively while the corresponding estimates for any anxiety disorders were 18% and 10% respectively. A quadratic hockey-stick shaped curve explained the relationship between SUA and social phobia better than a linear trend. However, with regards to the other specific anxiety disorders and other subtypes of MDD, there was no consistent pattern of association. Further analyses using SLC2A9 rs6855911 variant, known to be strongly associated with SUA, supported the quadratic relationship observed between SUA phenotype and social phobia.ConclusionsA quadratic relationship between SUA and social phobia was observed consistent with a protective effect of moderately elevated SUA on social phobia, which disappears at higher concentrations. Further studies are needed to confirm our observations.

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Clinical correlation of alteration of endogenous antioxidant-uric acid level in major depressive disorder

Abstract: Derangement of antioxidant levels in major depressive

Cited by 52 publications

References 13 publications

An 1H NMR and UPLC–MS-based plasma metabonomic study to investigate the biochemical changes in chronic unpredictable mild stress model of depression

An 1H NMR and UPLC–MS-based plasma metabonomic study to investigate the biochemical changes in chronic unpredictable mild stress model of depression

Purinergic system dysfunction in mood disorders: a key target for developing improved therapeutics

Associations of Serum Uric Acid and SLC2A9 Variant with Depressive and Anxiety Disorders: A Population-Based Study

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