The relationship between orofacial clefts and consanguineous marriages: A hospital register-based study in Dharwad, South India

Abstract

This is the published version of a paper published in .Citation for the original published paper (version of record):Rajeev, B., Prasad, K., Shetty, P J., Preet, R. (2017) The relationship between orofacial clefts and consanguineous marriages: A hospital registerbased study in Dharwad, South India. There is a lack of literature reporting the number of people affected with OFCs due to consanguinity. Aims: The aim of this study is to report the occurrence of OFC and associated factors in relation to consanguinity from a craniofacial hospital specializing in OFCs, head and neck cancer, and trauma management in South India. Setting and Design: This was a hospital-based study, retrospective case record analysis. Methodology: One thousand two hundred and forty-seven consecutive patients' secondary data records with cleft lip (CL), cleft palate (CP) and cleft lip and palate (CL/P) were collected from January 2007 to July 2009. Statistics: Frequency of consanguinity in relation to OFC was analyzed using Chi-square test according to the nature of clefts and selected demographic features such as sex, region, and religion. Results: A total of 47.2% patients' parents had consanguineous marriage. Consanguinity was seen in 60.2% of male and 39.7% of female patients. CL/P was noticed in 40.9%, followed by CL (36.7%) and CP (22.2%). Males predominated in all types of clefts proportionally with the study population as compared to females. Statistically, significant association (P = 0.04) was seen with consanguinity and CP. Conclusion: Nearly half of the study population had a positive history of consanguinity. Statistically, a significant association was seen between CP and consanguinity. CL/P cases were the most common type identified, followed by CL and CP. Males predominated in all types of clefts. The Access this article online Website: www.jclpca.org

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“…Our study showed significant impact of consanguinity on both types of OFCs, which is consistent with other studies, 27,29 but contradicts others who found consanguinity effect on only 1 type of OFCs. Rajeev et al 35 found that parental consanguinity was significantly associated with CP ( P = 0.04), but not with cleft lip with or without cleft palate. Similar conclusion was reported by Sabbagh et al 30 and Saeed et al 31 On the other hand Leite and Koifman 36 found parental consanguinity was associated only with CL/P (OR = 3.8, 1.27–12.18).…”

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