The relationship between inflammation, endothelial dysfunction and proteinuria in patients with diabetic nephropathy

Taşlıpınar, Abdullah; Yaman, Halıl; Yılmaz, Mahmut İlker; Demirbaş, Şeref; Sağlam, Mutlu; Taşlıpınar, Mine Yavuz; Ağıllı, Mehmet; Kurt, Yasemin Gülcan; Sönmez, Alper; Azal, Ömer; Bolu, Erol; Yenicesu, Müjdat; Kutlu, Mustafa

doi:10.3109/00365513.2011.598944

Cited by 55 publications

(36 citation statements)

References 36 publications

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“…In lammation induced by endothelial dysfunction plays an important role in the development of albuminuria in diabetic patients [8], however, for the irst time, the current study demonstrated a signi icant relationship between the BH4/BH2 ratios (but not biopterin levels) with albuminuria. As this ratio includes information about the levels of both biopterins, may be a more sensitive and reliable marker of endothelial dysfunction and glomerular injury than the isolate values of BH4 or BH2 [9].…”

Section: Discussioncontrasting

confidence: 58%

Untitled

2017

J Clini Nephrol

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Endothelial dysfunction and infl ammation play a key role in the pathophysiology of diabetic nephropathy; Tetrahydrobiopterin (BH4) is an essential cofactor for nitric oxide synthase, when BH4 is reduced to dihydrobiopterin (BH2), endothelial dysfunction is induced. Purpose:The aim of this study is to evaluate the relationship between the levels of biopterins with albuminuria in type-2 diabetic hypertensive patients. Methods:We studied 30 hypertensive type-2 diabetic patients in whom biopterins levels were measured by reverse phase high performance liquid chromatography with fl uorescence detection. Additionally, 24 h urinary albumin excretion was also measured (nephelometry). The levels of biopterins and albuminuria were correlated with the Pearson correlation coeffi cient. Results:We did not fi nd a signifi cantly correlation between biopterins levels and albuminuria, However, we found a signifi cantly inverse correlation (R= -0.498, p<0.005) between the BH4/BH2 ratio and albuminuria. Conclusion:Our results suggest that the BH4/BH2 ratio instead of biopterins levels may be a marker of nephropathy in hypertensive type-2 diabetic patients.

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Section: Discussioncontrasting

confidence: 58%

Untitled

2017

J Clini Nephrol

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“…It determines the degree of endothelial dysfunction on the basis of NO production capacity of the brachial artery. There are reports in the literature showing decreased FMD in patients with diabetic nephropathy (16).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of biochemical and clinical markers of endothelial dysfunction and their correlation with urinary albumin excretion in patients with type 1 diabetes mellitus

Polat

Uğurlu

Aslan

et al. 2016

Arch. Endocrinol. Metab.

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Objective: Endothelial dysfunction (ED) plays an important role in the pathogenesis of diabetic nephropathy. The purpose of the study was to determine flow mediated endothelial dependent vasodilatation (FMD) measurements and serum soluble (s) endothelin-1 (ET-1), intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule (VCAM-1) levels in patients with type 1 diabetes mellitus (T1DM) with or without increased urinary albumin excretion (UAE) and compare them with the healthy controls. Subjects and methods: Seventy three patients with T1DM were enrolled. Patients were divided into two subgroups according to microalbumin measurements in 24-hr urine collections. The diabetic patients without microalbuminuria (41 patients) were defined as Group I and those with microalbuminuria (32 patients) were defined as group II. A hundred age and sex matched healthy subjects participated as the control group (Group III). Serum sET-1, sICAM-1, sVCAM-1 levels and FMD measurements were determined in all participants. Results: Median FMD measurement was significantly lower in the diabetic groups compared with the control group (6.6, 6.4 and 7.8% in Group I, II and III, respectively) (p < 0.05). FMD was negatively correlated with age (p = 0.042). Median serum sICAM-1 level was higher in the patient groups compared to the control group (p < 0.05). Median serum sVCAM-1 level was higher in the group of patients with increased albuminuria compared to the normoalbuinuric and the control group (p < 0.05). Serum sVCAM-1 level was found to be positively correlated with degree of urinary albumin excretion (p < 0.001). Conclusion: We assume that sVCAM-1 may be used as a predictive marker for risk stratification for nephropathy development and progression. Arch Endocrinol Metab. 2016;60(2):117-24

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“…6 Interleukin-6 (IL-6) and C-reactive protein (CRP), 2 sensitive physiologic markers of subclinical systemic inflammation, have been shown to be associated with hyperglycemia, endothelial dysfunction, and microvascular complications in patients with T2DM. 7,8 Further, these 2 inflammatory markers have been shown to initiate coagulation at several points in primary and secondary hemostatic systems. 9,10 Therefore, we speculated that plasma CRP and IL-6 concentrations might serve as markers of hypercoagulability and chronic inflammation in patients with T2DM.…”

mentioning

confidence: 99%

“…However, the associations and interactions between inflammation and hemostasis have not been fully established in T2DM, although a causal link between the 2 systems has been suggested. 8 In our study, we sought to compare plasma biomarkers of inflammation and coagulation in patients with T2DM who do not have complications and patients with T2DM who have microvascular complications. Also, we aimed to explore the associations between inflammatory markers, coagulation and fibrinolysis parameters, and microvascular complications in patients with T2DM.…”

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confidence: 99%

Associations Between Inflammatory Markers, Hemostatic Markers, and Microvascular Complications in 182 Chinese Patients With Type 2 Diabetes Mellitus

Zheng

Shi

Chen

et al. 2015

Lab Med

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Objective: To examine the associations between inflammatory markers, coagulation and fibrinolysis parameters, and microvascular complications in 182 Chinese patients with type 2 diabetes mellitus (T2DM) who sought treatment at a large hospital in Zhejiang province, China. Methods:We investigated the relationships of blood inflammatory markers with hemostatic markers in 87 patients with T2DM who did not have complications and 95 patients with T2DM who had microvascular complications.Results: C-reactive protein (CRP) and interleukin-6 (IL-6) were significantly correlated with fibrinogen, thrombin-antithrombin III complex (TAT III), plasminogen activator inhibitor-1 (PAI-1), von Willebrand factor (vWF), and coagulation factors (F) VII in patients with T2DM who had microvascular complications (P <.05). Based on logistic regression analysis, the highest-tertile groups of fibrinogen, FVII, and FVIII, corresponded to a greater risk of high CRP, whereas risk of high IL-6 was significantly greater in the groups with highesttertile values for fibrinogen, FVII, TAT III, PAI-1, and activated protein C (APC).Conclusions: Elevated levels of CRP and IL-6 might be associated with increased coagulability and a tendency towards thrombus formation in patients with T2DM who have microvascular complications.

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The relationship between inflammation, endothelial dysfunction and proteinuria in patients with diabetic nephropathy

Cited by 55 publications

References 36 publications

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Evaluation of biochemical and clinical markers of endothelial dysfunction and their correlation with urinary albumin excretion in patients with type 1 diabetes mellitus

Associations Between Inflammatory Markers, Hemostatic Markers, and Microvascular Complications in 182 Chinese Patients With Type 2 Diabetes Mellitus

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