The Relationship between Hair Zinc and Lead Levels and Clinical Features of Attention-Deficit Hyperactivity Disorder

Shin, Dong‐Won; Kim, Young Ho; Oh, Kap Sung; Shin, Young June; Lim, Se-won

doi:10.5765/jkacap.2014.25.1.28

Cited by 3 publications

(2 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Except for one study 24 in which both case and control groups had diabetes, other studies used healthy individuals and people with ADHD as control and case groups, respectively. Of the available studies, four were conducted in Egypt 24 , 28 , 29 , 33 , three in Russia 13 , 37 , 38 , two in Turkey 32 , 36 , two in the United States 34 , 41 , and others in Syria 25 , China 26 , Iran 27 , Slovakia 30 , Israel 31 , Saudi Arabia 35 , New Zealand 39 , Indonesia 40 , Thailand 12 , Korea 42 , and Georgia 43 . Twenty studies had case–control design and only two studies 13 , 28 were conducted by cross-sectional design.…”

Section: Resultsmentioning

confidence: 99%

Zinc status in attention-deficit/hyperactivity disorder: a systematic review and meta-analysis of observational studies

Ghoreishy

Mousavi

Asoudeh

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Previous studies regarding the zinc status in attention-deficit/hyperactivity disorder (ADHD) yielded inconsistent results. Thus, the present meta-analysis was aimed to estimate the association between hair and serum/plasma zinc levels and ADHD. Online databases of Medline, EMBASE, and Scopus were searched up to October 2020 with no limitation in time and language. Weighted mean differences (WMDs) of hair and serum/plasma zinc levels were calculated using a random-effects model. Overall, 22 articles with 1280 subjects with ADHD and 1200 controls were included. The pooled effect size indicated that serum/plasma zinc levels in subjects with ADHD were not statistically different than their controls (WMD = − 1.26 µmol/L; 95% CI − 3.72, 1.20). Interestingly, the exclusion of one study from the analysis showed that people with ADHD significantly have lower circulating levels of zinc compared to their controls (WMD: − 2.49 µmol/L; 95% CI − 4.29, − 0.69). Also, the pooled effect size indicated that hair zinc levels in cases with ADHD were not statistically different than their controls (WMD = − 24.19 μg/g; 95% CI − 61.80, 13.42). Present meta-analysis raises the possibility that subjects with ADHD are prone to have declined levels of zinc levels. Based on current findings, screening the zinc levels in subjects with ADHD could be reasonable. Further well-designed studies are needed to clarify the role of zinc in the etiology of ADHD.

show abstract

Section: Resultsmentioning

confidence: 99%

Zinc status in attention-deficit/hyperactivity disorder: a systematic review and meta-analysis of observational studies

Ghoreishy

Mousavi

Asoudeh

et al. 2021

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Attention deficit hyperactivity disorder (ADHD) is a neurobiological disorder with a prevalence of 5%-10% in the world that negatively impacts school behavior and achievement. The onset of this disorder usually appears in the school-age (1) . Many parents feel disconcerted in nurturingtheir children with ADHD since they often opposed, haphazardly behave,and disobey the rules (2,3) Parents, especially mothers, often have to lose their jobs because they have to take care of their ADHD children (4,5) .…”

Section: Introductionmentioning

confidence: 99%

Is there an Effect of Serotonin on Attention Deficit Hyperactivity Disorder

Setiawati

Mukono

Wahyuhadi

et al. 2020

Indian Journal of Public Health Research &Amp; Development

View full text Add to dashboard Cite

Background: Attention deficit hyperactivity disorder (ADHD) is a neurobiological disorder with a prevalence of 5%-10% in the world that negatively impacts school behavior and achievement. There have been many studies reveals that attention disorders are caused by the decreased levels of dopamine and norepinephrine neurotransmitter. However, particular concern nowadays are the emotional and behavioral problems. The emotional and behavioral problem is suspected to be caused by the decrease in serotonin level. The aim of this study was to determine the difference in serotonin level between ADHD and non-ADHD children.Method: This study was an observational case-control study design using random sampling method. Subject of this study was children in Bina Karya Elementary School Surabaya. ADHD severity was assessed using Conners Abreviated Rating Scale. Examination of serotonin levels in blood was done by ELISA method. Informed consent was signed by parents before the study. Data was analyzed using independent T-test.Results: 44 (23 ADHD and 21 non-ADHD) children from grade 1 to 6 was included in the study. Based on the gender, 13 children were girls and 31 children were boys. Serotonin level in ADHD children was significantly higher than non-ADHD children (2.148 ± 0.94 vs 2.006 ± 0.115 μmol/L; p = 0.0001). Conclusion:Serotonin level in ADHD children was significantly higher than non-ADHD children.

show abstract

A systematic review of the association between lead levels in hair and urine in children with attention deficit hyperactivity disorder (ADHD)

Sahu,

John,

Nayak

2023

IJPP

View full text Add to dashboard Cite

Attention deficit hyperactivity disorder (ADHD), characterised by inattentiveness, hyperkinetic behaviour, and impulsivity in childhood, leads to decreased academic performance and learning in general. Among the environmental factors, lead (Pb) in the environment is considered a crucial public health issue associated with ADHD. This study assessed the existing literature for the association of hair and urine lead levels with ADHD. The studies included in this systematic review were case-control observational and prevalence studies of a place or population. For hair Pb levels, out of 478 participants, 89 were ADHD cases and 389 controls showed a pooled effect of a standardised mean difference of 0.30 (0.03–0.57). The overall effect Z was 2.16, which was statistically significant (P = 0.03). For urine Pb levels, there were 196 ADHD cases and 423 healthy controls. The pooled effect of the standardised mean difference was 0.34 (0.13–0.56). The overall effect Z was 3.12, which was statistically significant (P = 0.002). Pb estimations can reduce the disease burden of ADHD by non-invasive methods such as in hair and urine, which have better acceptance by parents.

show abstract

The Relationship between Hair Zinc and Lead Levels and Clinical Features of Attention-Deficit Hyperactivity Disorder

Cited by 3 publications

References 31 publications

Zinc status in attention-deficit/hyperactivity disorder: a systematic review and meta-analysis of observational studies

Zinc status in attention-deficit/hyperactivity disorder: a systematic review and meta-analysis of observational studies

Is there an Effect of Serotonin on Attention Deficit Hyperactivity Disorder

A systematic review of the association between lead levels in hair and urine in children with attention deficit hyperactivity disorder (ADHD)

Contact Info

Product

Resources

About