The Relationship Between Ferroptosis and Diseases

Lv, Jinchang; Hou, Biao; Song, Jiangang; Xu, Yunhua; Xie, S.

doi:10.2147/jmdh.s382643

Cited by 16 publications

(13 citation statements)

References 120 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The Nrf2 pathway is a cellular defense mechanism that helps protect cells from oxidative stress by upregulating the expression of genes involved in antioxidant defense and detoxification. Vitamin K 2 has been shown to activate this pathway, leading to increased expression of antioxidant enzymes, including glutathione peroxidase [ 130 , 131 , 132 ]. Given the potential role of ferroptosis in COVID-19 pathogenesis and the possible link between vitamin K and ferroptosis, there is interest in exploring the potential therapeutic benefits of vitamin K in COVID-19.…”

Section: A Brief Overview Of Vitamin Kmentioning

confidence: 99%

Links between Vitamin K, Ferroptosis and SARS-CoV-2 Infection

et al. 2023

View full text Add to dashboard Cite

Ferroptosis is a recently discovered form of programmed cell death. It is characterized by the accumulation of iron and lipid hydroperoxides in cells. Vitamin K is known to have antioxidant properties and plays a role in reducing oxidative stress, particularly in lipid cell membranes. Vitamin K reduces the level of reactive oxygen species by modulating the expression of antioxidant enzymes. Additionally, vitamin K decreases inflammation and potentially prevents ferroptosis. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leading to coronavirus disease 2019 (COVID-19) is associated with oxidant–antioxidant imbalance. Studies have shown that intensified ferroptosis occurs in various tissues and cells affected by COVID-19. Vitamin K supplementation during SARS-CoV-2 infection may have a positive effect on reducing the severity of the disease. Preliminary research suggests that vitamin K may reduce lipid peroxidation and inhibit ferroptosis, potentially contributing to its therapeutic effects in COVID-19 patients. The links between ferroptosis, vitamin K, and SARS-CoV-2 infection require further investigation, particularly in the context of developing potential treatment strategies for COVID-19.

show abstract

Section: A Brief Overview Of Vitamin Kmentioning

confidence: 99%

Links between Vitamin K, Ferroptosis and SARS-CoV-2 Infection

et al. 2023

View full text Add to dashboard Cite

show abstract

“…It has been reported that ferroptosis is frequently observed in I/R‐induced tissue injury (Lv et al, 2022). Compared with the Con group, lower expressions of GPX4 and SLC7A11 were detected in the Mod group (Figure 3f,g, p < .01).…”

Section: Resultsmentioning

confidence: 99%

“…In organs and tissues, in addition to oxidative stress and inflammatory cascading leading to cell autophagy, apoptosis, and necrosis, ferroptosis has been frequently reported in recent years to be implicated in the occurrence and development of I/R injuries (Li et al, 2021; Yan et al, 2020). Ferroptosis is a newly identified form of programmed cell death that is characterized by iron‐dependent accumulation of lipid peroxidation, during which excess generation of ROS promotes oxidative stress to damage organelles such as mitochondria, endoplasmic reticulum, and Golgi apparatus (Lv et al, 2022; Stockwell et al, 2017). Available evidence has shown that ferroptosis plays a role in enlarging I/R injuries and suppression of ferroptosis can mitigate various tissue damage caused by I/R in vivo (Chen et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Syringic acid suppresses ferroptosis of skeletal muscle cells to alleviate lower limb ischemia/reperfusion injury in mice via the HMGB1 pathway

Wang,

Qi,

Gao

et al. 2023

Chem Biol Drug Des

View full text Add to dashboard Cite

Ischemia/reperfusion (I/R) of skeletal muscle in the lower limbs is an important factor affecting the outcome of lower limbs ischemia patients, with no effective preventive or therapeutic approaches available. The study was to investigate the effect of syringic acid (SA) on I/R skeletal muscle in the lower limbs injury. Mice femoral artery I/R models and C2C12 cell hypoxia/reoxygenation (H/R) models was establish, tissue damage, inflammatory status, and high mobility group box 1 (HMGB1) pathway were evaluated using histological analysis, enzyme‐linked immunosorbent assay, and western blotting. Further, the study detected the effect of SA on cell apoptosis, lipid peroxidation, Fe2+ level, and ferroptosis‐related proteins expression. Finally, the effect of HMGB1 expression on SA in H/R stimulation was studied. SA alleviated pathological damage and reduced levels of IL‐1β, IL‐6, and TNF‐α in muscle tissues from femoral artery I/R mouse models. SA upregulated Bcl‐2 and SOD as well as downregulated Bax, MDA, TBARS content, and Fe2+ level in H/R‐induced cells. SA inhibited HMGB1 expression and promoted Nrf2, HO‐1, GPX4, and SLC7A11 expressions in the injured tissues and cells. Such effects of SA on H/R‐induced cells were rescued by HMGB1 overexpression. SA suppressed ferroptosis of skeletal muscle cells to alleviate lower limb I/R injury in mice by blocking the HMGB1 pathway, providing new insights for the treatment of lower limb ischemia–reperfusion injury.

show abstract

“…73 New research suggests that the heat shock protein β-1 (HSPB1) reduces intracellular iron content by inhibiting the expression of TFR1, thereby inhibiting ferroptosis. 63…”

Section: Ferroptosis Signaling Pathways In Asthmamentioning

confidence: 99%

Ferroptosis triggers airway inflammation in asthma

Li,

Hou

et al. 2023

Ther Adv Respir Dis

View full text Add to dashboard Cite

Ferroptosis is a regulatory cell death characterized by intracellular iron accumulation and lipid peroxidation that leads to oxidative stress. Many signaling pathways such as iron metabolism, lipid metabolism, and amino acid metabolism precisely regulate the process of ferroptosis. Ferroptosis is involved in a variety of lung diseases, such as acute lung injury, chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis. Increasing studies suggest that ferroptosis is involved in the development of asthma. Ferroptosis plays an important role in asthma. Iron metabolism disorders, lipid peroxidation, amino acid metabolism disorders lead to the occurrence of ferroptosis in airway epithelial cells, and then aggravate clinical symptoms in asthmatic patients. Moreover, several regulators of ferroptosis are involved in the pathogenesis of asthma, such as Nrf2, heme oxygenase-1, mevalonate pathway, and ferroptosis inhibitor protein 1. Importantly, ferroptosis inhibitors improve asthma. Thus, the pathogenesis of ferroptosis and its contribution to the pathogenesis of asthma help us better understand the occurrence and development of asthma, and provide new directions in asthma treatment. This article aimed to review the role and mechanism of ferroptosis in asthma, describing the relationship between ferroptosis and asthma based on signaling pathways and related regulatory factors. At the same time, we summarized current observations of ferroptosis in eosinophils, airway epithelial cells, and airway smooth muscle cells in asthmatic patients.

show abstract

The Relationship Between Ferroptosis and Diseases

Cited by 16 publications

References 120 publications

Links between Vitamin K, Ferroptosis and SARS-CoV-2 Infection

Links between Vitamin K, Ferroptosis and SARS-CoV-2 Infection

Syringic acid suppresses ferroptosis of skeletal muscle cells to alleviate lower limb ischemia/reperfusion injury in mice via the HMGB1 pathway

Ferroptosis triggers airway inflammation in asthma

Contact Info

Product

Resources

About