The Relationship Between Dietary Total Antioxidant Capacity with Serum Antioxidant and Oxidant Parameters in Hemodialysis Patients

Ozkalayci, Ruveyda Esra; Çoban, Şermin; Rakıcıoğlu, Neslişah

doi:10.5152/turkjnephrol.2021.20004

Cited by 3 publications

(2 citation statements)

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“…Nevertheless, our model became even more complex after considering the effects of - SH groups on PON1 activity and considering that -SH groups including these in PON1 may contribute to the prediction of the TLE-PP-OS phenome. Indeed, protein thiols are often positively associated with PON1 activity [58] and are part of TRAP, while PON1 activity is often associated with TRAP levels [59,60]. PON1 activity is protected by antioxidants and thiol groups may be regenerated through reductive recycling by cell reductants including the glutathione system [61].…”

Section: Discussionmentioning

confidence: 99%

A novel pathway phenotype of temporal lobe epilepsy and comorbid psychiatric disorders: results of precision nomothetic medicine

Maes

Barbosa²,

Kanchanatawan

2022

Preprint

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No precision medicine models of temporal lobe epilepsy (TLE) and associated mental comorbidities were developed to date. This observational 11study aimed to develop a precision nomothetic, data driven comorbid TLE model with endophenotype classes and pathways phenotypes that may have prognostic and therapeutical implications. We recruited forty healthy controls and 108 TLE patients for this research and assessed TLE and psychopathology (PP) features as well as oxidative stress (OSTOX, e.g., malondialdehyde or MDA, lipid hydroperoxides, and advanced oxidation protein products) and antioxidant (paraoxonase 1 or PON1 status, -SH groups, and total radical trapping potential or TRAP) biomarkers. A large part (57.2%) of the variance in a latent vector (LV) extracted from the above TLE and PP features was explained by these OSTOX and antioxidant biomarkers. The PON1 Q192R genetic variant showed indirect effects on this LV which were completely mediated by PON1 activity and MDA. Factor analysis showed that a common core could be extracted from TLE, PP, OSTOX and antioxidant scores, indicating that these features are manifestations of a common underlying construct, i.e., a novel pathway phenotype of TLE. Based on the latter we constructed a new phenotype class that is characterized by increased severity of TLE, PP and OSTOX features and lowered antioxidant defenses. A large part of the variance in episode frequency was explained by increased MDA, lowered antioxidant, and nitric oxide metabolite levels. In conclusion a) PP symptoms belong to the TLE phenome and signal increased severity; and b) cumulative effects of aldehyde formation and lowered antioxidants determine epileptogenic kindling.

show abstract

Section: Discussionmentioning

confidence: 99%

A novel pathway phenotype of temporal lobe epilepsy and comorbid psychiatric disorders: results of precision nomothetic medicine

Maes

Barbosa²,

Kanchanatawan

2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Nevertheless, our model became even more complex after considering the effects of -SH groups on PON1 activity and considering that -SH groups, including these in PON1, may contribute to the prediction of the TLE-PP-OS phenome. Protein thiols are often positively associated with PON1 activity [64] and are part of TRAP, while PON1 activity is often associated with TRAP levels [65,66]. PON1 activity is protected by antioxidants, and thiol groups may be regenerated through reductive recycling by cell reductants, including the glutathione system [67].…”

Section: Oxidative Stress and The Tle-pp Common Corementioning

confidence: 99%

A Novel Pathway Phenotype of Temporal Lobe Epilepsy and Comorbid Psychiatric Disorders: Results of Precision Nomothetic Medicine

et al. 2022

View full text Add to dashboard Cite

No precision medicine models of temporal lobe epilepsy (TLE) and associated mental comorbidities have been developed to date. This observational study aimed to develop a precision nomothetic, data-driven comorbid TLE model with endophenotype classes and pathway phenotypes that may have prognostic and therapeutical implications. We recruited forty healthy controls and 108 TLE patients for this research and assessed TLE and psychopathology (PP) features as well as oxidative stress (OSTOX, e.g., malondialdehyde or MDA, lipid hydroperoxides, and advanced oxidation protein products) and antioxidant (paraoxonase 1 or PON1 status, -SH groups, and total radical trapping potential or TRAP) biomarkers. A large part (57.2%) of the variance in a latent vector (LV) extracted from the above TLE and PP features was explained by these OSTOX and antioxidant biomarkers. The PON1 Q192R genetic variant showed indirect effects on this LV, which were completely mediated by PON1 activity and MDA. Factor analysis showed that a common core could be extracted from TLE, PP, OSTOX and antioxidant scores, indicating that these features are manifestations of a common underlying construct, i.e., a novel pathway phenotype of TLE. Based on the latter, we constructed a new phenotype class that is characterized by increased severity of TLE, PP and OSTOX features and lowered antioxidant defenses. A large part of the variance in episode frequency was explained by increased MDA, lowered antioxidant, and nitric oxide metabolite levels. In conclusion, (a) PP symptoms belong to the TLE phenome, and the signal increased severity; and (b) cumulative effects of aldehyde formation and lowered antioxidants determine epileptogenic kindling.

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Association of dietary antioxidant indices with kidney function indicators in patients with type 2 diabetes: a cross-sectional study

Omid,

Esfahani,

Tabaeifard

et al. 2024

Sci Rep

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The Relationship Between Dietary Total Antioxidant Capacity with Serum Antioxidant and Oxidant Parameters in Hemodialysis Patients

Cited by 3 publications

References 0 publications

A novel pathway phenotype of temporal lobe epilepsy and comorbid psychiatric disorders: results of precision nomothetic medicine

A novel pathway phenotype of temporal lobe epilepsy and comorbid psychiatric disorders: results of precision nomothetic medicine

A Novel Pathway Phenotype of Temporal Lobe Epilepsy and Comorbid Psychiatric Disorders: Results of Precision Nomothetic Medicine

Association of dietary antioxidant indices with kidney function indicators in patients with type 2 diabetes: a cross-sectional study

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