The relationship between depressive symptoms and diabetic complications in elderly patients with diabetes: Analysis using the Diabetes Study from the Center of Tokyo Women's Medical University (DIACET)

Ishizawa, Kaya; Babazono, Tetsuya; Horiba, Yu; Nakajima, Junko; Takasaki, Keiko; Miura, Junnosuke; Sakura, Hiroshi; Uchigata, Yasuko

doi:10.1016/j.jdiacomp.2016.02.004

Cited by 46 publications

(48 citation statements)

References 25 publications

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“…The participants in this previous study had a longer diabetes disease duration and more patients had diabetic complications than those in the present study. The prevalence of depression might increase with a longer diabetes disease duration and a higher proportion of diabetic complications . Therefore, this could be one reason why the proportion of participants in the present study with depression differed from that in previous studies.…”

Section: Discussioncontrasting

confidence: 59%

“…In the present study, the J‐PHQ‐9 showed that depression was present in 20.3% of men and 26.8% of women. Previous research investigating the prevalence of depression in older patients with diabetes using the J‐PHQ‐9 reported a prevalence of 27.0% in men and 36.2% in women . The participants in this previous study had a longer diabetes disease duration and more patients had diabetic complications than those in the present study.…”

Section: Discussioncontrasting

confidence: 46%

See 1 more Smart Citation

Relationship between sarcopenia and depression in older patients with diabetes: An investigation using the Japanese version of SARC‐F

Ida

Murata

Nakai

et al. 2018

Geriatrics Gerontology Int

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Section: Discussioncontrasting

confidence: 59%

Section: Discussioncontrasting

confidence: 46%

Relationship between sarcopenia and depression in older patients with diabetes: An investigation using the Japanese version of SARC‐F

Ida

Murata

Nakai

et al. 2018

Geriatrics Gerontology Int

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“…Depression is a major risk factor in the development of type 2 diabetes,1,2 and patients with diabetes show about twice the prevalence of depression compared with the general population 3. It is reported that the presence of diabetic complications, low monthly family income, negative life event, and poor social support were the statistically significant risk factors associated with depression in diabetic patients 4,5. However, the pathophysiological mechanism remains unclear.…”

Section: Introductionmentioning

confidence: 99%

A novel herbal treatment reduces depressive-like behaviors and increases brain-derived neurotrophic factor levels in the brain of type 2 diabetic rats

Luo

Yuan

et al. 2016

NDT

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BackgroundRadix Puerariae and hawthorn fruit have been demonstrated to treat diabetes. They offer potential benefits for preventing depression in diabetes.ObjectiveThe aim of this study was to investigate whether the combination of Radix Puerariae and hawthorn fruit (CRPHF) could prevent depression in a diabetic rat model generated by feeding the rats with a high-fat diet and a low-dose streptozotocin (STZ).MethodsThe CRPHF was provided by the Shanghai Chinese Traditional Medical University. Twenty-four rats were randomly divided into four groups: normal control, normal-given-CRPHF (NC), diabetic control, and diabetic-given-CRPHF (DC) groups. The type 2 diabetic model was created by feeding the rats with a high-fat diet for 4 weeks followed by injection of 25 mg/kg STZ. CRPHF was given at 2 g/kg/d to the rats of NC and DC groups by intragastric gavage daily for 4 weeks after the type 2 diabetic model was successfully created. Body weight, random blood glucose (RBG), oral glucose tolerance test, total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were measured during the study. Depressive-like behavior was evaluated at the end of the treatment by using the open field test (OFT), the elevated plus-maze test (EPMT), locomotor activity test (LAT), and forced swimming test (FST). Levels of extracellular signal-regulated protein kinase (ERK) and brain-derived neurotrophic factor (BDNF) in the prefrontal cortex were evaluated by using Western blot.Results1) CRPHF reduced RBG and improved glucose tolerance in diabetic rats; 2) CRPHF reduced TC and TG but did not significantly change HDL-C or LDL-C in diabetic rats; 3) CRPHF reversed the loss in body weights observed in diabetic rats; 4) CRPHF reduced depressive-like behavior as measured by OFT, EPMT, LAT, and FST; 5) BDNF was upregulated, and ERK was activated in the prefrontal cortex of diabetic rats treated with CRPHF.ConclusionCRPHF has the potential of preventing depression in patients with diabetes.

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“…This is in contrast to other studies, which showed that MDD was not associated with diabetes duration 13,19–23 or that it was associated with a longer diabetes duration. 24–27 A recent study in elderly men with diabetes found a J-shaped association between self-reported diabetes duration and late-life depression, assessed by the Geriatric Depression Scale—the odds of depression was significantly higher in those with diabetes duration less than 10 years and greater than 20 and 30 years. 28 This study supports 2 hypotheses regarding the association of both short and long diabetes duration with depression.…”

Section: Discussionmentioning

confidence: 99%

The Prevalence and Specificity of Depression Diagnosis in a Clinic-Based Population of Adults With Type 2 Diabetes Mellitus

et al. 2017

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Objective To estimate the crude prevalence of minor depressive disorder (MinD) in a clinic-based population of adults with type 2 diabetes. Methods We screened a clinical sample of 702 adults with type 2 diabetes for depressive symptoms using the Patient Health Questionnaire-2 and performed a structured diagnostic psychiatric interview on 52 screen-positive and a convenience sample of 51 screen-negative individuals. Depressive disorder diagnoses were made using Diagnostic and Statistical Manual of Mental Disorders IV (DSM-IV) Text Revised criteria and categorized as MinD, major depressive disorder (MDD), or no depressive disorder. We estimated prevalence of MinD and MDD and derived 95% CIs. Results The crude prevalence of current, past, and current or past MinD was 4.3% (95% CI: 0.9–9.2%), 9.6% (95% CI: 3.9–15.9%), and 13.9% (95% CI: 7.7–21.2%), respectively. The crude prevalence of current, past, and current or past MDD was slightly higher—5.0% (95% CI: 1.9–9.4%), 12.0% (95% CI: 6.1–19.5%), and 17.0% (95% CI: 10.1–24.8%), respectively. There was a high prevalence of coexisting anxiety disorders in individuals with MinD (42.2%) and MDD (8.1%). Hemoglobin A1c levels were not significantly different in individuals with MinD or MDD compared to those without a depressive disorder. Conclusions MinD is comparably prevalent to MDD in patients with type 2 diabetes; both disorders are associated with concomitant anxiety disorders. MinD is not included in the DSM-5; however, our data support continuing to examine patients with chronic medical conditions for MinD.

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The relationship between depressive symptoms and diabetic complications in elderly patients with diabetes: Analysis using the Diabetes Study from the Center of Tokyo Women's Medical University (DIACET)

Cited by 46 publications

References 25 publications

Relationship between sarcopenia and depression in older patients with diabetes: An investigation using the Japanese version of SARC‐F

Relationship between sarcopenia and depression in older patients with diabetes: An investigation using the Japanese version of SARC‐F

A novel herbal treatment reduces depressive-like behaviors and increases brain-derived neurotrophic factor levels in the brain of type 2 diabetic rats

The Prevalence and Specificity of Depression Diagnosis in a Clinic-Based Population of Adults With Type 2 Diabetes Mellitus

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