Relationship between sarcopenia and depression in older patients with diabetes: An investigation using the Japanese version of SARC‐F

Ida, Satoshi; Murata, Kazuya; Nakai, Mari; Ito, Sho; Malmstrom, Theodore K.; Ishihara, Yuki; Imataka, Kanako; Uchida, Akihiro; Monguchi, Kou; Kaneko, Ryutaro; Fujiwara, Ryoko; Takahashi, Hiroka

doi:10.1111/ggi.13461

Cited by 16 publications

(16 citation statements)

References 30 publications

(89 reference statements)

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“…For example, in a recent study involving Japanese adults, decreased muscle mass (sarcopenia) was related to depression in older men with diabetes but not in older women. 13 Contrary to these previous studies, our data indicated that depressive mood was inversely associated with chair stand test performance, gait speed and standing balance test performance in both men and women. This difference in results might be explained by the inclusion of relatively 'young' older subjects (the average age was no more than 70 years), by the low severity of the reported depression or the small sample size in our study.…”

Section: Discussioncontrasting

confidence: 99%

“…12 In addition, a statistically significant relationship was observed between sarcopenia and depression in older male patients with diabetes. 13 A recent study involving Japanese urban-dwelling older adults revealed that depressive mood was not associated with decreased muscle mass but was associated with low muscle strength and low physical performance. 14 In contrast, results from the 2010-2011 Korean National Health and Nutrition Examination Survey showed that sarcopenia was not associated with depression in Korean adults.…”

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confidence: 98%

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Correlation of sarcopenia and depressive mood in older community dwellers: a cross-sectional observational study in China

Chen

Sheng

et al. 2020

BMJ Open

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ObjectiveWhether sarcopenia is detrimental to depression is still controversial, which may be due to the three components of the sarcopenia. Our objective was to define the correlation between depression and sarcopenia in older Chinese community dwellers.DesignThe study has a cross-sectional design.SettingThe study was conducted in Jiangsu, China.ParticipantsA total of 101 men and 149 women aged 60 years or older were recruited.Outcome measuresLean tissue mass was measured by dual-energy X-ray absorptiometry. Muscle strength in the upper and lower limbs was measured by a handheld dynamometer and a chair stand test, respectively. Physical performance was assessed by gait speed and standing balance tests. Depressive mood was assessed using the Geriatric Depression Scale-30 (range 0–30).ResultsParticipants in the sarcopenia group had a higher mean depression score than the normal group (p=0.002). Pearson’s correlation analysis showed that depression was negatively associated with muscle strength (handgrip strength: R=−0.170, p=0.028 for women, R=−0.196, p=0.048 for men; chair stand test performance: R=0.252, p=0.002 for women, R=0.311, p=0.001 for men) and physical performance (gait speed: R=−0.200, p=0.009, standing balance test performance: R=−0.224, p=0.006, Short Physical Performance Battery (SPPB): R=−0.218, p=0.007 for women; SPPB: R=−0.252, p=0.01 for men). Multiple linear regression models revealed that depressive mood was inversely associated with chair stand test (β=0.325, p<0.001), gait speed (β=−0.009, p=0.041) and standing balance test (β=−0.24, p=0.016) after adjusting for confounding factors, while no significant correlation was observed between depressive mood and muscle mass.ConclusionThe diagnostic components of sarcopenia—strength of the leg muscles (chair stand test) and physical performance (gait speed and standing balance test)—were associated with depressive mood.

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Section: Discussioncontrasting

confidence: 99%

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confidence: 98%

Correlation of sarcopenia and depressive mood in older community dwellers: a cross-sectional observational study in China

Chen

Sheng

et al. 2020

BMJ Open

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“…Primary sarcopenia is largely attributable to aging, while secondary sarcopenia can occur earlier in life in association with a range of other conditions [12,13]. Recent evidence showed that sarcopenia was positively associated with depressive symptoms assessed by self-rating scales among different populations, such as community-dwelling people and patients with type II diabetes, hemodialysis, end-stage kidney disease and cancer [14][15][16][17]. Sarcopenia, suicide and depression share common risk factors, such as chronic low-grade inflammation, brain-derived neurotropic factor (BDNF) dysfunction and dysregulated hypothalamic-pituitary-adrenal (HPA) axis [18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Association between suicide risk severity and sarcopenia in non-elderly Chinese inpatients with major depressive disorder

et al. 2020

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Background: Sarcopenia is a skeletal muscle disorder. Recent studies have shown an association between muscle health and suicide. However, there have been no previous studies on the relationship between suicide risk severity and sarcopenia in major depressive disorder (MDD). This study aimed to explore the association between suicide risk severity and sarcopenia in non-elderly Chinese inpatients with MDD. Methods: The first-episode drug-naïve MDD inpatients aged 20-59 years with the 24-item Hamilton Rating Scale for Depression (HAMD-24) scores of >20 were included, who were then classified into low, intermediate, high and very high suicide risk groups according to the Nurses' Global Assessment of Suicide Risk (NGASR). The HAMD-24, the Hamilton Rating Scale for Anxiety (HAMA) and the SARC-F questionnaire were used to assess depression severity, anxiety severity and sarcopenia, respectively. The plasma levels of cortisol and adrenocorticotropic hormone (ACTH) were measured. Results: A total of 192 MDD inpatients (122 females, 70 males; aged 39.3 ± 11.7 years) were included, with 12.5% meeting criteria for sarcopenia. There were significant differences in gender, HAMD score and prevalence of sarcopenia among the suicide risk groups. Adjusted ordinal regression analysis showed that sarcopenia was significantly associated with more severe suicide risk (OR = 2.39, 95%CI 1.02-5.58, p = 0.044) independent of depression severity. Conclusions: This study revealed that sarcopenia was significantly associated with higher suicide risk in non-elderly Chinese MDD inpatients after adjustment for depression severity. Intervention of sarcopenia might be effective in reducing the risk of suicide in non-elderly MDD patients.

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“…Recent evidence showed that sarcopenia was positively associated with depressive symptoms assessed by self-rating scales among different populations, such as community-dwelling people and patients with type II diabetes, hemodialysis, end-stage kidney disease and cancer [14][15][16][17].…”

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Association between suicide risk severity and sarcopenia in non-elderly Chinese inpatients with major depressive disorder

Fan

Yuan

Wei

et al. 2020

Preprint

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Abstract Background: Sarcopenia is a skeletal muscle disorder. Recent studies showed high rates of suicide in non-elderly adults and the association between muscle health and suicide. But there have been no previous studies on the relationship between suicide risk severity and sarcopenia in major depressive disorder (MDD). This study aimed to explore the association between suicide risk severity and sarcopenia in non-elderly Chinese inpatients with MDD. Methods: The first-episode drug-naïve MDD inpatients aged 20-59 years with the 24-item Hamilton Rating Scale for Depression (HAMD-24) scores of ＞20 were included, who were then classified into low, intermediate, high and very high suicide risk groups according to the Nurses' Global Assessment of Suicide Risk (NGASR). The HAMD-24, the Hamilton Rating Scale for Anxiety (HAMA) and the SARC-F questionnaire were used to assess depression severity, anxiety severity and sarcopenia, respectively. The plasma levels of cortisol and adrenocorticotropic hormone (ACTH) were measured. Results: A total of 192 MDD inpatients (122 females, 70 males; aged 39.3 ± 11.7 years) were included, with 12.5% of sarcopenia. There were significant differences in gender, HAMD score and prevalence of sarcopenia among the suicide risk groups. Adjusted ordinal regression analysis showed that sarcopenia was significantly associated with severer suicide risk (OR=2.39, 95%CI 1.02-5.58, p=.044). Conclusions: This study revealed that sarcopenia was significantly associated with higher suicide risk in non-elderly Chinese MDD inpatients after adjustment for depression severity. Intervention of sarcopenia might be effective to reduce the risk of suicide in non-elderly MDD patients.

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Relationship between sarcopenia and depression in older patients with diabetes: An investigation using the Japanese version of SARC‐F

Cited by 16 publications

References 30 publications

Correlation of sarcopenia and depressive mood in older community dwellers: a cross-sectional observational study in China

Correlation of sarcopenia and depressive mood in older community dwellers: a cross-sectional observational study in China

Association between suicide risk severity and sarcopenia in non-elderly Chinese inpatients with major depressive disorder

Association between suicide risk severity and sarcopenia in non-elderly Chinese inpatients with major depressive disorder

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