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Aim In the present study, we aimed to examine the association between sarcopenia and sleep disorder in older patients with diabetes using the Japanese version of SARC‐F (SARC‐F‐J). Methods Outpatients with diabetes (aged ≥65 years) at the Ise Red Cross Hospital were included in the present study. We used the Japanese version of the Pittsburgh Sleep Quality Index, which is a self‐administered questionnaire, to measure sleep disorder. To evaluate sarcopenia, we used SARC‐F‐J, a self‐administered questionnaire, comprising five items. For multiple logistic regression analysis, the dependent variable was sleep disorder and the explanatory variable was sarcopenia, and these were used for calculating the odds ratios of sarcopenia with regard to sleep disorder. Results In total, 318 patients were included in this study (189 men and 129 women). The prevalence of sarcopenia was 22.5% and that of sleep disorder was 44.8%. Adjusted odds ratios of sarcopenia and sleep disorder were 6.04 in men (95% CI 1.71–21.36, P = 0.005) and 6.33 in women (95% CI 1.91–20.97, P = 0.003). Conclusions We found a statistically significant association between sarcopenia and sleep disorder in older patients with diabetes using SARC‐F‐J. Therefore, older patients with diabetes should be cautioned regarding sleep disorder if they are diagnosed with sarcopenia. Geriatr Gerontol Int 2019; 19: 399–403.

The relative frequencies of OA within and between ethnic groups at certain joint sites have changed over time from the past to the present.

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A statistically significant relationship was shown between sarcopenia and depression in older male patients with diabetes. We believe that drawing the attention of physicians to sarcopenia prevalence by using the Japanese version of SARC-F will contribute to the detection of depression in older male patients with diabetes. Geriatr Gerontol Int 2018; 18: 1318-1322.

Relaxin-like factor (RLF), also known as insulin-like factor 3 (INSL3), is produced by testicular Leydig cells, but its specific receptor LGR8 (leucine-rich repeat family of G-protein-coupled receptor 8) has not been identified in goats. This study aimed to identify complementary DNA (cDNA) sequences of goat LGR8, and characterize the expression of both RLF and LGR8 in goat testes by RT-PCR and immunohistochemistry. Testes were collected from immature (3-month-old) and mature (24-month-old) Saanen goats, and partial cDNA sequences of the goat homologue of human LGR8 were identified. The sequence encoded a reduced peptide sequence of 167 amino acids, which corresponded to transmembrane regions 2 through 5, followed by the beginning of intracellular loop 3 of human LGR8. Expression of both LGR8 and RLF genes was drastically increased in mature testes compared with immature ones. Although RLF protein was restricted to Leydig cells, LGR8 protein was detected in both Leydig cells and seminiferous epithelial cells (possibly germ cells and Sertoli cells). These results reveal a possible existence of the RLF-LGR8 ligand-receptor system within the goat testis, suggesting that RLF may play a role in testicular function through LGR8 on Leydig cells and seminiferous epithelial cells in an autocrine and/or paracrine manner.

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