The Relationship between Calcium Retention and Body Stores of Calcium in the Rat: Effect of Age and of Vitamin D

Henry, K. M.; Kon, S. K.

doi:10.1079/bjn19530017

Cited by 66 publications

(18 citation statements)

References 23 publications

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“…Because bone undergoes continuous remodeling, there is an opportunity for periods of inadequacy to be resolved. For example, deficits in dietary calcium were reversed with calcium repletion or time (21–23) . In our study, the early disadvantages of adequate calcium CaCO 3 compared with that from NFDM largely resolved with age.…”

Section: Discussionmentioning

confidence: 48%

Dairy Versus Calcium Carbonate in Promoting Peak Bone Mass and Bone Maintenance During Subsequent Calcium Deficiency

Weaver

Janle

Martin

et al. 2009

Journal of Bone and Mineral Research

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Dairy products provide most of the calcium in the diet, but consumption of milk has declined steadily over the last six decades. We determined (1) benefits to bone formation in growing female SpragueDawley rats when calcium is derived from dairy versus CaCO 3 and (2) residual benefits of calcium provided by dairy to rats subsequently receiving a low-calcium diet. During growth, femurs from rats fed nonfat dry milk solids (NFDM) had 8.4% higher peak breaking force, 6.4% greater Ca content, 4.8% greater weight, 4% greater width, 1.2% greater density, 13.1% greater midshaft cortical thickness, and 16.7% greater midshaft cortical area than from rats fed CaCO 3 . These effects were unrelated to differences in calcium absorption or serum IGF-1, but the NFDM group had higher rates of bone formation. If maintained on an adequate calcium diet, many of these advantages disappeared. However, rats fed adequate Ca as NFDM versus CaCO 3 during growth and subsequently switched to deficient Ca as CaCO 3 had significantly (p < 0.0001) higher femoral BMD (1.3%), total bone Ca (7.2%), Ca concentration (4.6%), and cortical thickness (9.4%) and a trend (p = 0.02) toward greater peak breaking force (17%). Thus, NFDMs improved bone measures during growth and protected bone against a subsequent period of calcium depletion compared with CaCO 3 .

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Section: Discussionmentioning

confidence: 48%

Dairy Versus Calcium Carbonate in Promoting Peak Bone Mass and Bone Maintenance During Subsequent Calcium Deficiency

Weaver

Janle

Martin

et al. 2009

Journal of Bone and Mineral Research

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“…Henry and Kon (8) have already demonstrated that although bone mineralization depends on the calcium content of the diet during the growth period, calcification becomes normal at 1 year of age regard less of the dietary calcium level.…”

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confidence: 99%

Effect of Repletion with Dietary Calcium on Composition and Mechanical Properties of Bone of Calcium-Deprived Rats

Galfsky¹,

Wolinsky²,

Simkin³

et al. 1975

Ann Nutr Metab

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Four groups of rats were fed a low-calcium diet (0.02 %) and two groups a normal calcium diet (0.50 %). After 2 weeks one group from each dietary calcium level was sacrificed and the femurs examined. The remaining three groups which had been kept on the low-calcium diet were then given diets richer in calcium: 0.25, 0.35 and 0.5 %. The remaining group on the normal calcium diet continued receiving it. After two more weeks all animals were sacrificed and their femurs examined. Rats fed the low-calcium diet lagged behind in weight gain; ash content, breaking strength, and modulus of elasticity of their femurs were much lower than those of animals on the normal calcium diet. Feeding diets with increasing calcium content increased bone ash and improved mechanical properties. However, improvement of breaking strength and elasticity did not parallel strictly increases in mineralization. Repletion with a normal calcium diet (0.50 %) failed to increase bone ash to normal levels but mechanical properties were improved by repletion with substantially lower dietary calcium levels. Maximal breaking strength was obtained by repletion feeding with a dietary calcium level which failed to increase bone ash. It seems that factors other than mineralization determine breaking strength and elasticity of bone recovering from calcium deprivation.

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“…The subject of calcium (Ca) absorption, re tention and bone metabolism in aging is of interest not only from a gerontological view point but also because of its possible role in the pathogenesis of osteoporosis, essentially a condition of aging, probably multi factorial in nature [Albanese, 1977], It is likely that poor or decreased absorption and retention of Ca may contribute to the progressive loss of bone during senescence. The absorption of Ca has been reported to be less in mature than in growing animals [Henry and Kon, 1953;Hansard and Crowder, 1957;Milhaud et al, 1963] and humans [Canniggia et al, 1964[Canniggia et al, /1965Bullarnore ex al., 1970;Dequeker, 1975]. Or, if no aging effect on Ca absorp tion was detected, it was noted that the older animal was less able to adapt to decreased dietary Ca intake than younger ones [Henry et al, 1960;Draper, 1964].…”

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confidence: 99%

Calcium Metabolism in Aged Mice Ingesting a Lysine-Deficient Diet

Wolinsky¹

1982

Gerontology

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The Relationship between Calcium Retention and Body Stores of Calcium in the Rat: Effect of Age and of Vitamin D

Abstract: It is known that the rate of calcium absorption decreases with progressive calcification of the skeleton (see e.g. Fairbanks

Cited by 66 publications

References 23 publications

Dairy Versus Calcium Carbonate in Promoting Peak Bone Mass and Bone Maintenance During Subsequent Calcium Deficiency

Dairy Versus Calcium Carbonate in Promoting Peak Bone Mass and Bone Maintenance During Subsequent Calcium Deficiency

Effect of Repletion with Dietary Calcium on Composition and Mechanical Properties of Bone of Calcium-Deprived Rats

Calcium Metabolism in Aged Mice Ingesting a Lysine-Deficient Diet

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