Calcium Metabolism in Aged Mice Ingesting a Lysine-Deficient Diet

Wolinsky, Ira

doi:10.1159/000212528

Cited by 5 publications

(2 citation statements)

References 11 publications

(12 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been suggested that the essential amino acid lysine may play a role in Ca metabolism. Studies in animals and human subjects have shown that Ca absorption is higher when lysine intake is increased (Wolinsky & Fosmire, 1982;Civitelli et al 1992;Civitelli, 1993), but the underlying mechanism has not been identified.…”

Section: Calcium Balancementioning

confidence: 99%

Dietary protein and bone health

Ginty

2003

Proc. Nutr. Soc.

View full text Add to dashboard Cite

show abstract

Section: Calcium Balancementioning

confidence: 99%

Dietary protein and bone health

Ginty

2003

Proc. Nutr. Soc.

View full text Add to dashboard Cite

show abstract

“…Rats were obtained and sacrificed for study at 1, 13 and 25 months of age and weighed 104 ± 2, 380 ± 9 and 409 ± 10 g, respectively (group mean ± SEM). The exper imental design used was one recommended by a panel of the National Institute on Aging (NIA) as a model for aging studies and was used in a previous publica tion in this journal [Wolinsky and Fosmire, 1982). It included a group of 1-month-old rats which are young and still growing, a group of 13-month-old rats which are mature and non-growing and at approximately mid-life, and 25-month-old rats which are aged and near the end of their life span.…”

Section: Animalsmentioning

confidence: 99%

Lysozyme and Other Measures of Immunity in Young, Mature, and Aged Rats

1984

Self Cite

View full text Add to dashboard Cite

Lysozyme, peroxidase, serum proteins, and immunoglobulins were measured in young (1 month), mature (13 months), and aged rats (25 months). Circulating levels of immunoglobulins G and A increased with maturity as did the globulin fraction of serum protein. Concentration of the bactericidal enzyme, lysozyme, was significantly increased in serum and kidney and significantly decreased in spleens of aged rats.

show abstract

Effect of L-lysine on cytosolic calcium homeostasis in cultured human normal fibroblasts

et al. 1989

View full text Add to dashboard Cite

L-lysine, a cationic essential amino acid, has been reported to affect calcium transport in both intestine and kidney. In order to investigate whether this effect is associated with changes in cytosolic calcium homeostasis, we studied the effect of L-lysine deprivation on intracellular calcium concentration ([Ca2+]i), as well as 45Ca efflux and accumulation in normal human fibroblasts. Steady state [Ca2+]i, measured using fura-2 fluorescence in cells cultured for 18 hours in a L-lysine-free medium, was significantly higher than in cells grown in the presence of as little as 4 microM L-lysine. L-lysine deprivation also led to a significant decrease of 45Ca fractional efflux compared with cells grown in complete medium. This effect was paralleled by a significant decrease in 45Ca accumulation. Lack of L-arginine from the growth medium for the same time period had no effect on either [Ca2+]i, 45Ca efflux, or 45Ca accumulation rate. Presumably, the lack of L-lysine for a significant amount of time impairs the active mechanisms of calcium extrusion, which is only partially compensated by a reduction of calcium accumulation rate. This leads to an increased steady state [Ca2+]i. It is concluded that L-lysine is an important modulator of cytosolic calcium homeostasis.

show abstract

Calcium Metabolism in Aged Mice Ingesting a Lysine-Deficient Diet

Cited by 5 publications

References 11 publications

Dietary protein and bone health

Dietary protein and bone health

Lysozyme and Other Measures of Immunity in Young, Mature, and Aged Rats

Effect of L-lysine on cytosolic calcium homeostasis in cultured human normal fibroblasts

Contact Info

Product

Resources

About