The relation between the RANKL and resistin in menopausal women with osteoporosis

Al-Masaoodi, Rusul Ali; AL-Sallami, Alaauldeen S. M.; Al-Baseesee, Hamadallah

doi:10.1063/1.5123113

Cited by 3 publications

(4 citation statements)

References 57 publications

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“…We also found increasing levels of serum resistin in postmenopausal osteoporotic females. In line with our results, another study found increased resistin levels in menopausal women with osteoporosis than a healthy group ( 26 ). The plausible cause for this could be that in osteoporosis, the proinflammatory cytokines such as serum levels of IL-6, leptin, IL-1, and resistin increases and might be the main contributing factor in the pathogenesis of osteoporosis.…”

Section: Discussionsupporting

confidence: 92%

Association Between Vitamin D and Resistin in Postmenopausal Females With Altered Bone Health

Tariq

Khaliq

et al. 2021

Front. Endocrinol.

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BackgroundResistin is a relatively novel adipokine that has a role in bone remodeling and may regulate bone mineral density (BMD). Vitamin D and adipokines have a dynamic role in the body’s various metabolic processes, including bone metabolism, and may alter bone metabolism in relation to each other. This study aimed to investigate the association between vitamin D and serum resistin levels in postmenopausal non-osteoporotic and osteoporotic females.MethodsThis correlational analytical study was conducted on 161 postmenopausal females, divided into two groups, non-osteoporotic and osteoporotic, between 50–70 years. Bone mineral density (BMD) was assessed by dual-energy X-ray absorptiometry (DXA) scan. Serum resistin and vitamin D levels were analyzed by enzyme-linked immunosorbent assay (ELISA) method. Serum calcium, phosphate, and alkaline phosphatase with spectrophotometry. A correlation was checked using spearman’s rho correlation coefficient, and multivariate stepwise regression analysis was used to predict serum resistin levels.ResultsPostmenopausal females (n=161) having sufficient, insufficient and deficient levels of vitamin D were 87 (54.0%), 64 (39.8%), and 10 (6.2%), respectively. Lumbar spine BMD (p < 0.001), total hip BMD (p < 0.001), and serum resistin levels (p < 0.001) were significantly different between the two groups. There was a significant negative correlation between serum resistin and vitamin D in postmenopausal females (rho = -0.182, p = 0.021) and osteoporotic group (rho = -0.253, p = 0.019) but non-significant in non-osteoporotic group (rho = -0.077, p = 0.509). Serum vitamin D was found to be independent predictor of serum resistin levels, accounting for only 3% variance.ConclusionSerum vitamin D levels were low while serum resistin levels were high in postmenopausal osteoporotic females and vitamin D is a negative predictor of serum resistin levels.

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Section: Discussionsupporting

confidence: 92%

Association Between Vitamin D and Resistin in Postmenopausal Females With Altered Bone Health

Tariq

Khaliq

et al. 2021

Front. Endocrinol.

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“…Error 20±2.64) figure (6) , Disturbances in metabolic are famous clinical syndrome characters, especially, dyslipidemia which is very wellknown abnormality metabolic in PCOS female with a prevalence of up to 70% (22,23) . Resistance of insulin is a key PCOS pathophysiology and dyslipidemia in PCOS women may be therefore in accordance with that detected in the insulin resistant case: decreasing levels of apolipoprotein (Apo) A-I, and high-density lipoproteincholesterol (HDL-C), and increased levels of ApoB, triglycerides (TG) and very low-density lipoprotein (24,25,26) .…”

Section: Resultssupporting

confidence: 54%

“…Although the unknown cause of PCOS, PCOS has been connected to obesity and insulin resistance (5) .There are 3 most well-known elements with PCOS associated i.e. irregularities of ovulation, androgen levels enhancement, and problems of cystic ovaries with elevated androgen levels and ovulation take place in most PCOS women (24,26) . Furthermore, alopecia, hirsutism, and acne are directly associated with elevation levels of androgen and the ovaries prevalence of polycystic on pelvic ultrasound more than 70% in PCOS patients (6) .…”

Section: Introductionmentioning

confidence: 99%

The Role of CTX-II , Dyslipidemia ,Vitamin D in Polycystic Ovary Syndrome

2020

IJFMT

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This study aimed to study the serum measurement of clinical value of type II collagen (CTX-II) in syndrome of polycystic ovary in women and indicter as osteoarthritis disease marker analyzed in future levels with a recent available immune enzyme-linked sorbent assay (ELISA) kit. For increasing sensitivity test, the protocol was modified. Levels of CTX-II increased significantly as well total protein, while decrease vitamin D and difference in lipid profile were practical between the patients compared with healthy women's. The obtained results suggested the monitoring interest of the serum CTX-II for the OA development in patients of polycystic ovary syndrome in women and the relevance of the analysis of multiple time point for this biomarker.

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“…(6) , Disturbances in metabolic are famous clinical syndrome characters, especially, dyslipidemia which is very wellknown abnormality metabolic in PCOS female with a prevalence of up to 70% (22,23) . Resistance of insulin is a key PCOS pathophysiology and dyslipidemia in PCOS women may be therefore in accordance with that detected in the insulin resistant case: decreasing levels of apolipoprotein (Apo) A-I, and high-density lipoproteincholesterol (HDL-C), and increased levels of ApoB, triglycerides (TG) and very low-density lipoprotein (24,25,26) .…”

Section: P a T I E N T S H E A L T H Ysupporting

confidence: 54%