Objectives:This study aimed to evaluate the cognitive levels of Multiple Choice Questions (MCQs) & Short Answer Questions (SAQs) and types of Item Writing Flaws (IWFs) in MCQs in Medical Pharmacology internal assessment exams.Methods:This descriptive, study was conducted over a period of six months, from December 2015 to May 2016 and evaluated six internal assessment examinations comprising SAQs and MCQs. A total of 150 MCQs and 43 SAQs were analyzed. These questions were administered to third-year medical students in the year of 2015. All SAQs were reviewed for their cognitive levels and MCQs were reviewed for cognitive levels as well as for IWFs. Items were classified as flawed if they contained one or more than one flaw. The cognitive level of the questions was determined by the modified Bloom’s taxonomy.Results:The proportion of flawed items out of 150 items in six exams ranged from 16% to 52%. While the percentage of total flawed items was 28%. Most common types of flaws were implausible distractors 19.69% (26), extra detail in correct option 18.18% (24), vague terms 9.85% (13), unfocused stem 9.09% (12) and absolute terms 9.09% (12). The two-third of MCQs 97(64.67%) were assessing the recall of information, while 29 (19.33%) and 24 (16%) were assessing the interpretation of data and problem-solving skills respectively. The majority of the SAQs (90.7%) were assessing recall of the information and only 9.3% were assessing interpretation of data while none of the questions was assessing the problem-solving skills.Conclusions:The cognitive level of assessment tools (SAQs & MCQs) is low, and IWFS are common in the MCQs. Therefore, faculty should be urged and groomed to design problem-solving questions which are devoid of any flaws.

Objectives: The study was planned to determine whether serum calcium, phosphate and alkaline phosphatase (ALP) are predictors of bone mineral density (BMD) in postmenopausal non-osteoporotic, osteopenic, and osteoporotic females. Methods: In this cross sectional study, conducted at Shaikh Zayed Hospital, Lahore in the year 2014-2015, postmenopausal females between 50-70 years of age were taken and divided into three groups non-osteoporotic (n=52), osteopenic (n=69) and osteoporotic (n=47). Serum ALP, phosphate and calcium were used in a stepwise multiple regression analysis to predict T-score in these groups. Results: In normal postmenopausal females, the prediction model was statistically significant, F(2, 41) = 6.041, p < 0.05 and showed a T-score variance of 22%. T-score was primarily predicted by higher levels of phosphate and calcium. In postmenopausal osteopenic females, T-score was only predicted by lower levels of ALP. The model was statistically significant, F(1, 59) = 4.995, p < 0.05, and accounted for approximately 7% of the variance of T-score. In postmenopausal osteoporotic females, the prediction model contained no predictors. Conclusion: Our study suggested that calcium and phosphate are the strongest predictors of T-score in postmenopausal normal females, while in postmenopausal osteopenic females ALP was the strongest predictor of T-score. Elevated serum ALP levels may help in determining loss of BMD in postmenopausal females. doi: https://doi.org/10.12669/pjms.35.3.188 How to cite this:Tariq S, Tariq S, Lone KP, Khaliq S. Alkaline phosphatase is a predictor of Bone Mineral Density in postmenopausal females. Pak J Med Sci. 2019;35(3):---------. doi: https://doi.org/10.12669/pjms.35.3.188 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Introduction: The multidrug-resistant (MDR) Salmonella enterica serovar Typhi isolates have been increasingly reported from the Asian and African countries. The emergence of isolates with decreased susceptibility to fluoroquinolones and cephalosporins has worsened the situation. Recently, an outbreak from Sindh, Pakistan was reported caused by extensively drug-resistant (XDR) S. Typhi strains. Methodology: In the present study, a total of 82 cases of typhoid have been investigated during 2018 from the febrile children referred to a tertiary care hospital in the population-wise largest province (Punjab) of Pakistan. S. Typhi was identified by standard microbiological techniques and isolates were characterized for antimicrobial resistance profiling and minimum inhibitory concentrations were determined. The presence of various ESBL genes in S. Typhi was confirmed by the PCR. Results: Out of the 82 isolates tested, 35 (43%) were found to be XDR; resistant to the first-line drugs. The resistance to third-generation cephalosporins was mainly mediated by extended-spectrum beta-lactamases i.e. blaTEM and blaCTX-M genes. Conclusions: The higher prevalence of ESBL producing Salmonella typhi clinical strains raises the concern about transmission prevention and infection management in the community as well as clinical settings. Moreover, the study highlights the problem concerning the declining antibiotic arsenal for the therapeutic management of typhoid fever and the emergence and spread of XDR strains in Pakistan.

Objectives: We aimed to investigate knowledge, attitudes, and practices regarding coronavirus in a sample of the general Pakistani population. Methods: This survey was carried out through The University of Faisalabad (TUF), Pakistan, between February 2020 to April 2020. The questionnaire was circulated on various online platforms to gather information. The data was analyzed on SPSS-22. Results: Out of 2121 respondents [13.7% were male, and 86.3% were females], 7.4% were married, 4.5% had a high income, 5.8% had fewer family members. COVID-19 knowledge scores were significantly low in < 21 years age group as compared to 21 to 25 (p < 0.001) and >25 years age group (p < 0.001). The males, married community, high income people, few family members had significantly higher coronavirus knowledge than respective groups (p = 0.033; p = 0.001; p < 0.001; p = 0.042, respectively). Conclusion: Our findings suggest knowledge score among our study population was not up to the mark. However, a positive correlation between the correct knowledge and appropriate attitude and practice was found among study participants. Older age groups and the group of high income were associated with adequate knowledge scores.

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