Catsper 1 is an important protein involved in calcium channel synthesis. These channels are essential for the hyperactivity of sperm flagellum, chemotaxis towards the egg, capacitation and acrosome reaction. Data analysis from unexplained infertility (n=50), idiopathic infertile men (Asthenozoospermia (n=50), Oligozoospermia (n=50)), and Normospermia fertile men as a control (n=26). The expression of CatSper1 protein expression in spermatozoa was reduced in unexplained infertility (mean± SD. Error 64.32±2.5 and in Asthenozoospermia 46.6±2.1and Oligozoospermia 53.86±4.1 while significant increase was observed in Normospermia fertile men 115.19±2.3. CatSper1 protein expressions was shown to have a positive correlation between sperm concentration, Sperm Progressive motility percentage and sperm normal morphology present in idiopathic infertile men respectively (r= 0.822, r = 0.651 and r = 0.742). A positive correlation was found between CatSper1 protein expression and sperm concentration, Sperm Progressive motility percentage and sperm normal morphology present in unexplained infertile men Respectively (r=0.845, r = 0.576 and r = 0.582). The present study shows the importance of protein catsper 1 in infertile men and its positive correlation with sperm parameters.

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This study was conducted on 84 Iraqi women samples under the ICSI program. The sample was divided into two parts: intravenous blood section for WBC measurement and serum section for antiphospholipid (IgG & IgM) measurement, while hCG was used to indicate the success of ICSI and the presence or absence of pregnancy. The results showed a significant difference (p < 0.05) between the pregnancy failure group and the abortion group compared with the control group (pregnancy continuation) about the level of Antiphospholipid (IgG-IgM) and WBC. The current study found a positive relationship between the level of Antiphospholipid (IgG-IgM) and WBC of these two factors, concluded that both criteria may indicate one for the other in women who suffer from miscarriage and pregnancy failure after ICSI.

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