The relation between salivary sIgA level and caries incidence in Down syndrome children

Rosdiana, Rosdiana; Rizal, Mochamad Fahlevi

doi:10.20473/j.djmkg.v45.i2.p79-83

Cited by 4 publications

(5 citation statements)

References 14 publications

(26 reference statements)

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“…Caries-free condition is associated with the diet behavior of a child with DS, clean environment, controlled diet, hypodontia, microdontia, a diastema, saliva's high (pH) concentration, and delayed eruption pattern. 22,23 This study concurs with other studies that found similar DMF-T/ def-t scores in individuals with DS and healthy children. This was caused by low awareness of oral health among the population, lack of preventive programs, and bad oral health promotion.…”

Section: Discussionsupporting

confidence: 91%

Parents' Behavior Related to Caries Status of Children with Down Syndrome in Surabaya

et al. 2021

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Background. Down syndrome (DS) is a chromosome disorder due to the presence of all or part of a third copy of chromosome 21 (trisomy 21) caused by a failure in chromosome segregation. Following Riset Kesehatan Dasar (RISKESDAS) in 2013, the number of people with DS in Indonesia increased compared to 2010, with an estimated 924 children with DS in Surabaya. Data regarding caries status in children with DS in Surabaya is limited. Objective. To evaluate parents’ behavior (predisposing, enabling, and reinforcing factors) related to the caries status of children with DS. Methods. This observational analytic cross-sectional study included children aged ≤18 years with DS and parents who were members of the Parents' Association of Children with Down Syndrome (POTADS). Caries status were measured using the DMF-T/def-t score, and parents were asked to fill out a questionnaire. Data were analyzed using Spearman’s correlation test. Result. We included 46 children with DS in this study. The DMF-t / def-t index of children with DS (7.2) was categorized as very high according to WHO. There was a significant relationship between lack of knowledge of parents and caries status in children with DS. Enabling factors and reinforcing factors were not significantly correlated with caries status. Conclusion. Parents' behavior is correlated with the caries status of children with DS. All combination of three factors behavior, including predisposing, enabling and reinforcing, are needed to reduce the number of caries in children with DS.

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Section: Discussionsupporting

confidence: 91%

Parents' Behavior Related to Caries Status of Children with Down Syndrome in Surabaya

et al. 2021

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“…They found that age was the only dependent factor which was associated with dental caries affecting permanent teeth. Rosdiana R et al [20] stated that delayed tooth eruption, spacing between the teeth, increased pH, microdontia, and raised levels of sodium, calcium, and bicarbonate causes reduced caries incidence in children with Down syndrome. They also found that caries decreases with increased levels of salivary sIgA.…”

Section: Research Studiesmentioning

confidence: 99%

Dental Caries and Salivary Immunoglobulin A in Down Syndrome

Najmuddin,

Devang,

Sola Arulogun

2024

TIJPH

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Down syndrome (DS) is defined as trisomy chromosome 21, which is observed to be the most prevalent autosomal genetic anomaly. Salivary immunoglobulin A (sIgA) plays an important role in defence mechanism against the microbial pathogens that can invade the surface of mucosa. In children with DS, raised sIgA levels cause an increase in immune mechanism against dental caries. The evidence about the salivary IgA levels in children suffering from Down syndrome is contradictory and limited in the literature. Thus, there is a terrible requirement to conduct more longitudinal prospective studies on saliva of DS patients taking large sample sizes to assess the molecular interactions. The present review is aimed to evaluate the association of Dental caries and salivary immunoglobulin A in Down syndrome individuals. The sources were searched from a database of PubMed from 2004 to 2023 (last 19 years). The inclusion criteria included key words of microdontia, delayed eruption, dental anomalies, retained teeth, anodontia, fissured lip and tongue, macroglossia, hypodontia in Down syndrome. The 22 articles that met the selection criteria (most of them were review article and some observational studies) were included to this review, of which some of the studies have been conducted to assess the role of sIgA in relation to dental caries and observed that increased sIgA levels decrease the rate of incidence of dental caries. The present review revealed that patients suffering with Down syndrome are at an increased risk of dental caries because of impaired motor activities, malocclusion and affected quality of life.

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“…Each IgA monomer is composed of four polypeptides, two of which are heavy chains and two of which are light chains (22) . Antigen exposure, level of stress or emotional state, diet, salivary flow, salivary stimulation, age, activity intensity, hormonal and genetic background have an effect on the production and concentration of salivary sIgA (23) . sIgA antibodies inhibit bacterial binding, colonization, metabolism, and penetration across mucosal surfaces, as well as neutralize viruses, enzymes, and toxins.…”

Section: Salivary Secretory Immunoglobulin a (Siga)mentioning

confidence: 99%

“…S. mutans colonization is reduced by sIgA because it inhibits the activity of GTF, preventing the production of glucans. As a result, bacterial adhesion does not occur during the plaque formation mechanism (23) . sIgA inhibits attachment facilitated by Glucan Binding Protein (GBP) and the accumulation of S. mutans in acidic or critical environments where the biofilm becomes pathogenic by releasing lactic acid and causing tooth demineralization (20) .…”

Section: Salivary Secretory Immunoglobulin a (Siga)mentioning

confidence: 99%

Salivary sIgA as a predictor of caries risk in stunting children

Tedjosasongko¹,

Marwah²,

Dewi³

2022

World J. Adv. Res. Rev.

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Background: Stunting has a detrimental influence on the health and development of children and has a number of negative consequences, including an increase in mortality as a result of a loss in bodily immunity, which makes youngsters more susceptible to illness. Additionally, there are impairments in cognitive capacities, as well as learning and productivity in adulthood. Stunting prevalence is relatively high in Indonesia, at 30.8%, compared to the global prevalence of 22.2%. Stunting children tend to have protein energy malnutrition (PEM) condition, which can lead in salivary gland atrophy, decrease sIgA levels, and disrupting the buffering system, cleansing, and antibacterial agents. It is able to increase the risk of dental caries. The purpose of this review is to determine whether salivary sIgA levels can be used to predict the risk of developing caries in stunted children.

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The relation between salivary sIgA level and caries incidence in Down syndrome children

Cited by 4 publications

References 14 publications

Parents' Behavior Related to Caries Status of Children with Down Syndrome in Surabaya

Parents' Behavior Related to Caries Status of Children with Down Syndrome in Surabaya

Dental Caries and Salivary Immunoglobulin A in Down Syndrome

Salivary sIgA as a predictor of caries risk in stunting children

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