The relation between apelin levels, echocardiographic findings and carotid intima media thickness in peritoneal dialysis patients

Abstract

Background: Cardiovascular disease (CVD) is the most important cause of morbidity and mortality in patients with end stage renal disease (ESRD). Apelin expressed in endothelial and other tissues including brain and kidney is an adipocytokine defined recently and is emerging an important mediator of cardiovascular homeostasis. The aim of this study was to test whether apelin levels might be associated with carotid artery atherosclerosis and left ventricular mass index (LVMI) in peritoneal dialysis patients. Patients and methods: Fifty peritoneal dialysis patients (25 female, mean age 41.4 ± 11.9 years, mean dialysis vintage 65.0 ± 35.4 months) and 18 healthy individuals (9 female, mean age 41.7 ± 6.8 years) were included in this cross-sectional study. Serum apelin 12 levels, echocardiographic findings and carotid intima media thickness (CIMT) were recorded as well as clinical and laboratory data. Results: There were no differences between the patient and the control groups with regard to demographic characteristics. In patient group, LVMI, CIMT, CRP and apelin levels were elevated compared to control group. However there was no association between apelin, LVMI and CIMT. There was a positive correlation between apelin and CRP, which was not statistically significant. When patients were divided into two groups according to the mean serum apelin levels, LVMI, CIMT and CRP were higher in the high apelin group but this difference did not reach statistical significance. Conclusion: We observed an increased inflammation and CVD risk in peritoneal dialysis patients. However, serum apelin levels seem not to be associated with cardiovascular risk in this group of patients.

role of Apelin, Adipsin and C-reactive protein in patients with chronic kidney disease

“…The results of the current study are in agreement with the results of Zhang et al (2009), Büyükbakkal et al (2015). They found that apelin levels were higher in dialysis patients than in healthy individuals.…”

Baseline carotid intima‐media thickness is associated with cardiovascular morbidity and mortality in peritoneal dialysis patients

“…It has been shown in several studies that CIMT measurements are associated with LV concentric hypertrophy and predict cardiovascular death in hemodialysis patients [8][9][10]. Our group and others have shown increased CIMT measurements in PD patients as compared to the general population [11,12]. However, the role of CIMT in predicting cardiovascular morbidity or mortality is less clear.…”

Elabela Attenuates the TGF-β1-Induced Epithelial-Mesenchymal Transition of Peritoneal Mesothelial Cells in Patients Receiving Peritoneal Dialysis

“…lower serum APLN levels than healthy individuals (Małyszko et al, 2006). On the contrary, the detection of serum APLN level in patients on HD and PD indicated that the level of APLN was higher than that in the normal population (Büyükbakkal et al, 2015;Dogan et al, 2018). The latest detection of serum APLN levels in patients with PD also indicated that APLN levels in this set of patients were higher than those in the normal population (Karaer Büberci et al, 2022).…”