role of Apelin, Adipsin and C-reactive protein in patients with chronic kidney disease

Abstract

Chronic kidney disease (CKD) is a growing global health problem. The adipose tissue may directly affect the kidney through its activity as an endocrine gland through the secretion of adipokines. This study was a cross sectional which conducted in Kirkuk city for the period from June 2020 to September 2021.study population age ranged from (30 – 90) years old. The total of 80 subjects was separated to two groups as following: Kidney failure group: 65 patients and control group: 15 patients. The results referred to the increased levels of Apelin, Adipsin and C reactive protein (CRP) in CKD with highly significant differences (P≤0.01) when compared with control group, also a positive correlation was found between Adipsin and Apelin in the second stage (r = 0.742) , the third stage (r = 0.573) and in the fifth stage (r = 0.552).