The red wine polyphenol, resveratrol improves hemodynamics, oxidative defence and aortal structure in essential and malignant hypertension

Grujić-Milanović, Jelica; Miloradović, Zoran; Jovović, Djurdjica; Jacević, Vesna; Milosavljević, Ivica; Milanović, Svetlana; Mihailović-Stanojević, Nevena

doi:10.1016/j.jff.2017.04.035

Cited by 17 publications

(19 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is well known that arterial hypertension is associated with a rise in reactive oxygen species (ROS) [ 49 , 50 ]. Several studies have shown alteration of oxidative status in LNHR and an improvement after treatment with an antioxidant substance [ 51 , 52 ].…”

Section: Discussionmentioning

confidence: 99%

Antihypertensive Effects of the Vitex cienkowskii (Verbenaceae) Stem-Bark Extract on L-NAME-Induced Hypertensive Rats

Donfack

Atsamo

Guemmogne

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Vitex cienkowskii stem-bark is used in Cameroonian traditional medicine to treat cardiovascular diseases including hypertension. In previous studies, the methanol/methylene chloride stem-bark extract of Vitex cienkowskii (MMVC) showed a preventive activity in L-NAME-induced hypertension and improved blood pressure of spontaneously hypertensive rats. The present study investigated the curative effects in L-NAME-induced hypertensive rats (LNHR). Hypertension was induced in rats by oral administration of L-NAME (40 mg/kg/day) for 28 days. The animals were divided into 2 groups: one group of 5 rats receiving distilled water (10 ml/kg) and another 20 rats receiving L-NAME. At the end of 4 weeks of administration of L-NAME, the animals were divided into 4 groups of 5 rats each: one group of hypertensive rats receiving distilled water, another one receiving captopril (25 mg/kg), and two groups of hypertensive rats receiving MMVC at doses of 200 and 400 mg/kg, respectively. Body weight, food, and water intake were measured weekly. At the end of the treatment, blood pressure and heart rate were recorded by invasive method. Whole heart, left ventricle, kidneys, and liver were weighed. The effects of plant extract on lipid profile and oxidative stress markers, as well as markers of hepatic and renal functions were assessed spectrophotometrically according to well described protocols. Results show that L-NAME significantly increases the mean arterial blood pressure (MABP), atherogenic index, lipid profile, and creatinine and transaminase activities of normotensive rats. MMVC significantly reduced the blood pressure in LNHR. Body weight, food and water intake, left ventricular hypertrophy, antioxidant level, renal and hepatic markers, and lipid profile were improved by the treatment with MMVC. The curative effect of MMVC on L-NAME-induced hypertension is probably related to its antihypertensive, hypolipidemic, and antioxidant properties. These results confirmed the use of Vitex cienkowskii for the treatment of hypertension in traditional medicine.

show abstract

Section: Discussionmentioning

confidence: 99%

Antihypertensive Effects of the Vitex cienkowskii (Verbenaceae) Stem-Bark Extract on L-NAME-Induced Hypertensive Rats

Donfack

Atsamo

Guemmogne

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…Malignant hypertension can develop from essential hypertension through serious long-term inhibition of endothelium-derived, vasodilatory, nitric oxide (NO). In particular, persistent N G -L-Arginine Methyl Ester (L-NAME) ( Figure 1 B) inhibition of NO biosynthesis in SHRs leads to a significant increase in blood pressure followed by profound vasoconstriction, oxidative stress, and structural alterations of the conduit and large arteries, as well as cardiac hypertrophy [ 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…It is found in all cell types of the cardiovascular system, including cardiac myocytes, vascular smooth muscle, endothelial cells, fibroblasts, and blood cells [ 15 ]. The endothelial cell dysfunction in hypertension relates to the abundance of TGF-β in the arterial wall, which promotes intimal proliferation as well as the development of vascular lesions accompanied by apoptosis in the vascular smooth muscle cells [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…Several studies reported that resveratrol possessed antioxidant [ 23 ], anti-inflammatory [ 24 ], and proapoptotic activity [ 25 ]. Dietary polyphenol, resveratrol, has potential to improve endothelial dysfunction and decrease overall blood pressure [ 5 , 26 ]. In the hypertensive condition, resveratrol decreases vascular oxidative stress by scavenging H 2 O 2 and preventing oxidative stress-induced endothelial cell death [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Resveratrol Protects Cardiac Tissue in Experimental Malignant Hypertension Due to Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Properties

Grujić-Milanović

Jacević

Miloradović

et al. 2021

IJMS

View full text Add to dashboard Cite

Hypertension is one of the most prevalent and powerful contributors of cardiovascular diseases. Malignant hypertension is a relatively rare but extremely severe form of hypertension accompanied with heart, brain, and renal impairment. Resveratrol, a recently described grape-derived, polyphenolic antioxidant molecule, has been proposed as an effective agent in the prevention of cardiovascular diseases. This study was designed to examine chronic resveratrol administration on blood pressure, oxidative stress, and inflammation, with special emphasis on cardiac structure and function in two models of experimental hypertension. The experiments were performed in spontaneously (SHRs) and malignantly hypertensive rats (MHRs). The chronic administration of resveratrol significantly decreased blood pressure in both spontaneously and malignant hypertensive animals. The resveratrol treatment ameliorated morphological changes in the heart tissue. The immunohistochemistry of the heart tissue after resveratrol treatment showed that both TGF-β and Bax were not present in the myocytes of SHRs and were present mainly in the myocytes of MHRs. Resveratrol suppressed lipid peroxidation and significantly improved oxidative status and release of NO. These results suggest that resveratrol prevents hypertrophic and apoptotic consequences induced by high blood pressure with more pronounced effects in malignant hypertension.

show abstract

“…The mechanism of RSV on blood vessels mainly was explained through its effects on endothelium. Endothelium-dependent mechanisms of relaxation by RSV include stimulation of endothelial NO production, inhibition of superoxide-mediated NO inactivation (1,15) and stimulation of endothelium dependent hyperpolarization (EDH) (16). The endothelium-independent relaxation is partly mediated by different K channels in the membrane of vascular smooth muscle cells, including voltage-gated K (Kv) channels, big Ca-activated K (BK Ca ) channels, but not adenosine triphosphate-sensitive K (K ATP ) channels (5,6).…”

Section: Introductionmentioning

confidence: 99%

Potassium channels on smooth muscle as a molecular target for plant-derived Resveratrol

Rajković

Djokic

Gostimirović

et al. 2020

Cell Mol Biol (Noisy-le-grand)

View full text Add to dashboard Cite

Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a phytoalexin present in a variety of plant species. Resveratrol has a wide spectrum of pharmacologic properties, and it exhibits versatile biological effects on different human and animal models. The studies have shown that potassium (K) channels can be potential targets in the mechanism of resveratrol action. K channels play a crucial role in maintaining membrane potential. Inhibition of K channels causes membrane depolarization and then contraction of smooth muscles, while the activation leads to membrane hyperpolarization and subsequently, relaxation. Five diverse types of K channels have been identified in smooth muscle cells in different tissue: ATP-sensitive K channels (K ATP ), voltage-dependent K channels (Kv), Ca 2+ -and voltagedependent K channels (BK Ca ), inward rectifier K channels (Kir), and tandem two-pore K channels (K 2P ). The expression and activity of K channels altered in many types of diseases. Aberrant function or expression of K channels can be underlying in pathologies such as cardiac arrhythmia, diabetes mellitus, hypertension, preterm birth, preeclampsia, and various types of cancer. Modulation of K channel activity by molecular approaches and selective drug development may be a novel treatment modality for these dysfunctions in the future. The plant-derived non-toxic polyphenols, such as resveratrol, can alter K channel activity and lead to the desired outcome. This review presents the basic properties, physiological, pathophysiological functions of K channels, and pharmacological roles of resveratrol on the major types of K channels that have been determined in smooth muscle cells.

show abstract

The red wine polyphenol, resveratrol improves hemodynamics, oxidative defence and aortal structure in essential and malignant hypertension

Cited by 17 publications

References 45 publications

Antihypertensive Effects of the Vitex cienkowskii (Verbenaceae) Stem-Bark Extract on L-NAME-Induced Hypertensive Rats

Antihypertensive Effects of the Vitex cienkowskii (Verbenaceae) Stem-Bark Extract on L-NAME-Induced Hypertensive Rats

Resveratrol Protects Cardiac Tissue in Experimental Malignant Hypertension Due to Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Properties

Potassium channels on smooth muscle as a molecular target for plant-derived Resveratrol

Contact Info

Product

Resources

About