Resveratrol (RSV), a plant-derived polyphenol, demonstrates broad-spectrum health benefits, including anti-proliferative, anti-inflammatory, antidiabetic, anti-ischemic and antioxidant effects. The aim of this review is to give an important heads-up regarding the influence of RSV as a phytoestrogen, RSV effects on most common pregnancy-related complications, as well as its impact on the embryogenesis, spermatogenesis, and women’s reproductive health. Considering the important implications of RSV on human reproductive health, this overview could provide a groundwork, encouraging more detailed research at the clinical level.
Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a phytoalexin present in a variety of plant species. Resveratrol has a wide spectrum of pharmacologic properties, and it exhibits versatile biological effects on different human and animal models. The studies have shown that potassium (K) channels can be potential targets in the mechanism of resveratrol action. K channels play a crucial role in maintaining membrane potential. Inhibition of K channels causes membrane depolarization and then contraction of smooth muscles, while the activation leads to membrane hyperpolarization and subsequently, relaxation. Five diverse types of K channels have been identified in smooth muscle cells in different tissue: ATP-sensitive K channels (K ATP ), voltage-dependent K channels (Kv), Ca 2+ -and voltagedependent K channels (BK Ca ), inward rectifier K channels (Kir), and tandem two-pore K channels (K 2P ). The expression and activity of K channels altered in many types of diseases. Aberrant function or expression of K channels can be underlying in pathologies such as cardiac arrhythmia, diabetes mellitus, hypertension, preterm birth, preeclampsia, and various types of cancer. Modulation of K channel activity by molecular approaches and selective drug development may be a novel treatment modality for these dysfunctions in the future. The plant-derived non-toxic polyphenols, such as resveratrol, can alter K channel activity and lead to the desired outcome. This review presents the basic properties, physiological, pathophysiological functions of K channels, and pharmacological roles of resveratrol on the major types of K channels that have been determined in smooth muscle cells.
Regardless of the continuous improvement of diagnostic possibilities and the organizational structure of the healthcare system that contribute to the reduction of the complicated courses of diseases, modern socio-economic and environmental stressors, life habits and increased fluctuation in the psychological functioning of an individual still have a great influence on the overall burden of human diseases. At present, etiological factors and pathogenic mechanisms of numerous diseases are known, thus enabling their continuous and timely pharmacotherapy. However, for progressive diseases or those associated with numeorus complications, pharmacological treatment can lead to the side effects, and preventive measures are highlighted as the main strategy in the management of such diseases, especially in chronic non-communicable diseases such as cardiovascular diseases (CVDs). One of the preventive measures is timely and qualitative supplementation of the diet with beneficial micronutrients and oligoelements. Their main sources are represented in plant fibers that synthesize biologically active substances with a polyphenolic ring in their structure, called natural polyphenolic compounds (NPC). Decades of NPC research have brought new insights into the potential modification of existing pharmacotherapy of numeorus diseases. Currently, it is known that many polyphenols have an optimal pharmacological profile with cardioprotection and at the center of their overall effects. Research into the mechanisms of polyphenolic action is exhaustive, their interactions with numerous subcellular structures have been described, and they are refered as promising molecules, with the potential to modify key pathogenetic elements that lead to the progression of various diseases. So far, their numerous effects on endothelium, smooth muscle cells and lipid cells involved in the process of atherogenesis are known, their antidiabetic, antioxidant, anti-inflammatory and immunomodulatory properties have been proven, and the synergy with the intestinal microbial populations has recently been known to contribute to their beneficial effects. This paper has the aim to point out the most important mechanisms that NPC use to improve general functionality of the organism by stimulating its defense capacity, prolonging cell life and delaying its overall aging. As the most important cardioprotective nutrients, a special focus is given to their beneficial effects on cardiovascular and metabolic function.
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