Resveratrol Protects Cardiac Tissue in Experimental Malignant Hypertension Due to Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Properties

Grujić-Milanović, Jelica; Jacević, Vesna; Miloradović, Zoran; Jovović, Djurdjica; Milosavljević, Ivica; Milanović, Svetlana; Mihailović-Stanojević, Nevena

doi:10.3390/ijms22095006

Cited by 20 publications

(14 citation statements)

References 53 publications

(81 reference statements)

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“…Previous studies verified that RESV suppresses NF κ B activation and gene expression along with the expression of proinflammatory cytokines [ 35 ]. According to Grujic Milanovic et al, RESV intake protected the cardiomyocytes through the inhibition of MPO activity, suggesting its promising anti-inflammatory and cardioprotective properties [ 36 ]. A remarkable finding from Yan et al discussed that RESV improved cardiovascular function by decreasing circulating levels of proinflammatory cytokines such as of tumor necrosis factor- α (TNF- α ) or interleukin-6 (IL-6) and by suppressing nuclear factor kappa B (NF- κ B) pathway [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Resveratrol as a Promising Polyphenol in Age-Associated Cardiac Alterations

Börzsei

Sebestyén

Szabó

et al. 2022

Oxidative Medicine and Cellular Longevity

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According to a widely accepted theory, oxidative stress is considered to be the number one trigger of aging-associated degenerative processes including cardiovascular diseases. In the context of aging-research, resveratrol receives special attention with its surprising number of health benefits. The aim of our study was to examine the anti-inflammatory and antioxidant effects of this dietary polyphenol in aging rat heart. 20-month-old female and male Wistar rats were divided into control (untreated) and resveratrol-treated groups. Resveratrol was administered at a dose of 0.05 mg/ml for 12 weeks dissolved in drinking water, while the control rats received ad libitum water. Cardiac level of reactive oxygen species (ROS), nuclear factor kappa B (NFκB), tumor necrosis factor alpha (TNF-α), and glutathione (GSH) parameters, as well as the activity of myeloperoxidase (MPO) and heme oxygenase (HO) enzymes were detected. Together with the biochemical measurements, hearts were isolated and used for an exposure of ischemic-reperfusion injury via Langendorff perfusion system. 12 week of resveratrol treatment suppressed the age-related inflammatory pathways including the expression of TNF-α, NFκB, and the activity of MPO while intensified the endogenous antioxidant defenses through the induction of GSH and HO system. Presumably, as a result of these processes, the necrotic area of the heart in response to an acute injury was also significantly reduced in the resveratrol-treated groups. Our findings confirmed that resveratrol has cardioprotective effects at several points by counteracting the aging-associated cellular malfunctions in the heart.

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Section: Discussionmentioning

confidence: 99%

Resveratrol as a Promising Polyphenol in Age-Associated Cardiac Alterations

Börzsei

Sebestyén

Szabó

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…Resveratrol, a nonflavonoid polyphenolic compound found in grapes, Thuja, peanuts, and many other plants, mediating anti-inflammatory effects and inhibiting the function of cyclooxygenase and hydroperoxidase, is widely used in research on cardiovascular protection [ 33 ]. Epidemiological research has proven that resveratrol can prevent various diseases, including atherosclerosis and other cardiovascular diseases [ 34 ]. Resveratrol exerts some physiological functions in VSMCs, including inhibition of high glucose-induced migration mediated by focal adhesion kinase and attenuation of homocysteine-mediated cell proliferation [ 20 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

Resveratrol Inhibits Insulin-Induced Vascular Smooth Muscle Cell Proliferation and Migration by Activating SIRT1

Wang

Lei

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) are essential for the development of hypertension. Insulin has been identified to promote VSMC proliferation and migration; resveratrol has been shown to have protective effects against cardiovascular diseases. This study aimed to investigate the effect of resveratrol on insulin-induced VSMC proliferation and migration and its potential mechanism. VSMC proliferation was measured by Cell Counting Kit-8 (CCK-8), cell counting method, and 5-ethynyl-2′-deoxyuridine (EdU) incorporation assay. Cell migration was detected by wound healing assay and transwell method. Expression of silent information regulator of transcription 1 (SIRT1) and phosphorylation levels of signaling molecules, such as phosphatidylinositol 3-kinase (PI3K) and protein kinase B (Akt), in VSMCs were detected by Western blotting. Resveratrol (25-150 μM) was found to inhibit insulin-induced VSMC proliferation. Pretreatment with 100 μM resveratrol reduced insulin (100 nM)-mediated VSMC migration. LY294002, an inhibitor of PI3K, inhibited the stimulatory effect of insulin (100 nM) on the proliferation of VSMCs. Treatment with resveratrol also decreased insulin-induced stimulatory effect on PI3K and Akt phosphorylation levels. Moreover, resveratrol treatment increased SIRT1 protein expression in VSMCs. A SIRT1 inhibitor, EX527, reversed the inhibitory effect of resveratrol on insulin-induced VSMC proliferation and migration and activation of PI3K and Akt phosphorylation levels. In conclusion, our study revealed that treatment with resveratrol inhibited insulin-mediated VSMC proliferation and migration, possibly by activating SIRT1 and downregulating the PI3K/AKT pathway.

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“…Other in vitro and in vivo studies also showed that GP possesses antioxidant activity useful in the management of the prooxidant status, considered a key factor in atherosclerosis development. Thus, GP can increase SOD, CAT, GPx, and/or GRx levels [ 79 , 80 , 81 , 82 ] and reduce ROS GSH, TBARS, and/or superoxide levels [ 83 , 84 , 85 ] being useful in primary prophylaxis.…”

Section: In Vitro and In Vivo Studies—grape Pomace Antioxidant And An...mentioning

confidence: 99%

Antioxidant and Anti-Inflammatory Actions of Polyphenols from Red and White Grape Pomace in Ischemic Heart Diseases

et al. 2022

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Grape pomace (GP) represents a very reliable source of polyphenols because it could be found globally as a remnant of the wine industry. During the winemaking process, two types of GP are generated: red GP and white GP, according to the produced wine, red or white. Grape pomace represents a viable source of polyphenols, mainly flavanols, procyanidins anthocyanins, and resveratrol which possess antioxidant and anti-inflammatory activities. Multiple differences were observed between red and white GP in terms of their antioxidant and anti-inflammatory activity in both in vitro and in vivo studies. Although most studies are focused on the antioxidant and anti-inflammatory effect of red grape pomace, there are still many variables that need to be taken into consideration, as well as extensive study of the white GP. It was observed that in both in vitro and in vivo studies, the GP polyphenols have a direct antioxidant activity by acting as a free radical scavenger or donating a hydrogen atom. It also possesses an indirect antioxidant and anti-inflammatory activity by reducing mitochondrial reactive oxygen species (ROS) generation, malondialdehyde (MDA), tumor necrosis factor-alpha (TNF-α), interleukin-1-beta (IL-1β), interleukin-6 (IL-6), nuclear factor kappa-light-chain-enhancer of activated B cells (NF- κβ), and inhibitor of nuclear factor kappa-B kinase subunit beta (Iκκβ) levels or nitrate oxide-4 (NOX4) expression and by increasing the levels of antioxidants enzymes like superoxide dismutase (SOD), catalase (CAT) glutathione reductase (GRx) and glutathione peroxidase(GPx). Besides these activities, many beneficial effects in ischemic heart diseases were also observed, such as the maintenance of the ventricular function as close as possible to normal, and the prevention of infarcted area extension. In this context, this review intends to present the actual knowledge of grape pomace’s potential antioxidant and anti-inflammatory activity in ischemic heart disease, knowledge gathered from existing in vitro and in vivo studies focused on this.

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Resveratrol Protects Cardiac Tissue in Experimental Malignant Hypertension Due to Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Properties

Cited by 20 publications

References 53 publications

Resveratrol as a Promising Polyphenol in Age-Associated Cardiac Alterations

Resveratrol as a Promising Polyphenol in Age-Associated Cardiac Alterations

Resveratrol Inhibits Insulin-Induced Vascular Smooth Muscle Cell Proliferation and Migration by Activating SIRT1

Antioxidant and Anti-Inflammatory Actions of Polyphenols from Red and White Grape Pomace in Ischemic Heart Diseases

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