The quantified EEG characteristics of responders and non-responders to long-term treatment with atomoxetine in children with attention deficit hyperactivity disorders

Chiarenza, Giuseppe A.; Chabot, Robert J.; Isenhart, Robert; Montaldi, Luciano; Chiarenza, Marco P.; Torto, Maria Grazia Lo; Prichep, Leslie S.

doi:10.1016/j.ijpsycho.2016.04.004

Cited by 18 publications

(23 citation statements)

References 68 publications

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“…But, EEG power spectra significantly increased especially in the occipital-temporal regions about the pre-methylphenidate control group. Although some studies in the literature have shown that stimulants do not have much effect on EEG frequency band changes[28, 29, 30], in our study, the changes in EEG frequency after methylphenidate use support the similar results of many studies in the literature [1, 7, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 31, 32]. …”

Section: Discussionsupporting

confidence: 89%

“…In a study in which the effects of atomoxetine inhibitor on EEG and on children with ADHD were investigated, a few topographic changes in EEG bands and great increases at beta band after atomoxetine use were observed, and they concluded that they could return QEEG profile to normal to a large extent, and that atomoxetine caused a decrease in the absolute theta in the posterior region, and an increase in absolute beta (especially in the right and midline frontal regions), which was revealed in the EEG records that they received one hour after the application of atomoxetine, and that delta band showed an increase especially in the central regions, and beta band increased as a whole. They also concluded that there was not any significant stimulant effect on the alpha activity, atomoxetine had minimal long-term effects on QEEG changes in their present study, atomoxetine caused the normalization of QEEGs of those who responded to atomoxetine, but it had no effect on QEEGs of those who did not respond to atomoxetine [1, 8, 30]. …”

Section: Discussionmentioning

confidence: 48%

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Evaluation of two types of drug treatment with QEEG in children with ADHD

Aldemir

Demirci

Bayram

et al. 2018

Translational Neuroscience

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AimsThe aim of this study is to evalute the effects of methylphenidate and atomoxetine treatments on electroencephalography (EEG) signals in volunteer children diagnosed with Attention Deficit and Hyperactivity Disorder(ADHD).MethodsThe study contained 40 children all of whom were between the ages of 7 and 17. The participants were classified into two groups as ADHD (n=20), which was in itself divided into two groups as ADHD-MPH (ADHD- Metylphenidate treatment) (n=10) and as ADHD-ATX (ADHD-Atomoxetin treatment) (n=10), and one control group (n=20). Following the first EEG recordings of the ADHD group, long-acting methylphenidate dose was applied to one ADHD group and atomoxetine dose was applied to the other ADHD group. The effect of optimal dosage is about for 4-6 weeks in general. Therefore, the response or lack of response to the treatment was evaluated three months after the beginning of the treatment.After methylphenidate and atomoxetine drug treatment, in order to obtain mean and maximum power values for delta, theta, alpha and beta band, the EEG data were analyzed.ResultsThe EEG power spectrum densities in all the bands yielded similar findings in both methylphenidate and atomoxetine. Although statistically significant frequency values of the electrodes were amplitude and maximally varied, in general, they appeared mostly at both frontal and temporal regions for methylphenidate and atomoxetine.ConclusionEspecially, after atomoxetine treatment, Quantitative Electroencephalography (QEEG) rates at frontal area electrodes were found statistically more significant than methylphenidate QEEG rates. What has been researched in this study is not only whether QEEG is likely to support the diagnosis, but whether changes on QEEG by treatment may be related to the severity of ADHD as well.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 48%

Evaluation of two types of drug treatment with QEEG in children with ADHD

Aldemir

Demirci

Bayram

et al. 2018

Translational Neuroscience

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“…Across all 3 studies, theta was reduced after an acute dose of 20 mg, 78 12 weeks of 40 to 100 mg/d, 79 or between 0.5 and 1.2 mg/kg for at least 6 months. 80 It should be noted that Leuchter et al did not find differences in quantitative EEG, but did find significant differences in the left temporoparietal theta in a young adult ADHD population. 79 Along with the change in theta power, Barry et al 78 also reported a global increase in absolute delta and beta.…”

Section: Pharmacological Treatment Effects On Eegmentioning

confidence: 86%

Measuring Treatment Response in Pharmacological and Lifestyle Interventions Using Electroencephalography in ADHD: A Review

Kirkland

Holton

2019

Clin EEG Neurosci

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Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by inattention, hyperactivity, and/or impulsivity with associations to short- and long-term aversive life events. The exact etiology of the disorder is still unknown. ADHD is heterogeneous in symptomology and a single consistent, reliable biomarker has not been found. Quantitative electroencephalography (EEG) has been proposed as a potential way to differentiate those with ADHD from typically developing controls; however, the data on the diagnostic utility of this approach have been variable. Quantitative EEG has been employed in prognostic ways to assess differences in baseline spectral power profiles and pharmacological and nonpharmacological treatment effects on electrocortical activity within the ADHD population. The aim of this review is to summarize the literature investigating the degree of normalization of resting-state EEG profiles in individuals with ADHD through various interventions, including stimulant and nonstimulant medication, exercise, and diet.

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“…QEEG analysis has been most often applied to spontaneous EEG signals acquired at rest, when a patient is instructed to relax with eyes open or closed (Kaiser, 2007 ; Thatcher, 2011 ). Specific alterations in the resting-state EEG signals have been found in various neurodevelopmental disorders, especially ADHD (Arns et al, 2014 ; Roh et al, 2015 ; Chiarenza et al, 2016 ), ADD (Thompson and Thompson, 1998 ), dyslexia (Arns et al, 2007 ), and autism (Billeci et al, 2013 ). Evidence on resting-state brain activity in CAPD is scarce.…”

Section: Introductionmentioning

confidence: 99%

Abnormal Resting-State Quantitative Electroencephalogram in Children With Central Auditory Processing Disorder: A Pilot Study

et al. 2018

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In this study, we showed an abnormal resting-state quantitative electroencephalogram (QEEG) pattern in children with central auditory processing disorder (CAPD). Twenty-seven children (16 male, 11 female; mean age = 10.7 years) with CAPD and no symptoms of other developmental disorders, as well as 23 age- and sex-matched, typically developing children (TDC, 11 male, 13 female; mean age = 11.8 years) underwent examination of central auditory processes (CAPs) and QEEG evaluation consisting of two randomly presented blocks of “Eyes Open” (EO) or “Eyes Closed” (EC) recordings. Significant correlations between individual frequency band powers and CAP tests performance were found. The QEEG studies revealed that in CAPD relative to TDC there was no effect of decreased delta absolute power (1.5–4 Hz) in EO compared to the EC condition. Furthermore, children with CAPD showed increased theta power (4–8 Hz) in the frontal area, a tendency toward elevated theta power in EO block, and reduced low-frequency beta power (12–15 Hz) in the bilateral occipital and the left temporo-occipital regions for both EO and EC conditions. Decreased middle-frequency beta power (15–18 Hz) in children with CAPD was observed only in the EC block. The findings of the present study suggest that QEEG could be an adequate tool to discriminate children with CAPD from normally developing children. Correlation analysis shows relationship between the individual EEG resting frequency bands and the CAPs. Increased power of slow waves and decreased power of fast rhythms could indicate abnormal functioning (hypoarousal of the cortex and/or an immaturity) of brain areas not specialized in auditory information processing.

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The quantified EEG characteristics of responders and non-responders to long-term treatment with atomoxetine in children with attention deficit hyperactivity disorders

Cited by 18 publications

References 68 publications

Evaluation of two types of drug treatment with QEEG in children with ADHD

Evaluation of two types of drug treatment with QEEG in children with ADHD

Measuring Treatment Response in Pharmacological and Lifestyle Interventions Using Electroencephalography in ADHD: A Review

Abnormal Resting-State Quantitative Electroencephalogram in Children With Central Auditory Processing Disorder: A Pilot Study

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