IntroductionThe objective of the presented study was to develop and evaluate a P300 experimental protocol for simultaneous registration of event-related potentials (ERPs) and functional MRI (fMRI) data with continuous imaging. It may be useful for investigating attention and working memory processes in specific populations, such as children and neuropsychiatric patients.Materials and methodsEleven children were investigated with simultaneous ERP–fMRI. To fulfill requirements of both BOLD and electroencephalographic signal registration, a modified oddball task was used. To verify the ERP–fMRI protocol we also performed a study outside the scanner using a typical two-stimuli oddball paradigm.ResultsLocalization of the P300 component of ERPs partially corresponded with fMRI results in the frontal and parietal brain regions. FMRI activations were found in: middle frontal gyrus, insula, SMA, parietal lobule, thalamus, and cerebellum. Our modified oddball task provided ERP–fMRI results with high level of significance (EEG SNR = 35, fMRI p < 0.05–Bonf.). ERPs obtained in the scanner were comparable with those registered outside the scanner, although some differences in the amplitude were noticed, mainly in the N100 component.ConclusionIn our opinion the presented paradigm may be successfully applied for simultaneous ERP–fMRI registration of neural correlates of attention in vulnerable populations.

This study is the first to demonstrate outcomes of slow cortical potential (SCP) Neurofeedback training in chronic tinnitus. A 50-year old male patient with tinnitus participated in three SCP training blocks, separated with 1-month breaks. After the training the patient reported decreased tinnitus loudness and pitch, as well as improved quality of daily life. A quantitative electroencephalography analysis revealed close to normal changes of resting state bioelectrical activity in cortical areas considered to be involved in tinnitus generation. The present case study indicates that SCP Neurofeedback training can be considered a promising method for tinnitus treatment.

Previous research has indicated that inner ear function might be modulated by visual attention, although the results have not been totally conclusive. Conceivably, modulation of hearing might occur due to stimulation of the cochlea via descending medial olivocochlear (MOC) neurons. The aim of the present study was to test whether increased visual attention caused corresponding changes in inner ear function, which was measured by the strength of otoacoustic emissions (OAEs) recorded from the ear canal in response to a steady train of clicks. To manipulate attention, we asked subjects to attend to, or ignore, visual stimuli delivered according to an odd-ball paradigm. The subjects were presented with two types of visual stimuli: standard and deviant (20% of all stimuli, randomly presented). During a passive part of the experiment, subjects had to just observe a pattern of squares on a computer screen. In an active condition, the subject’s task was to silently count the occasional inverted (deviant) pattern on the screen. At all times, visual evoked potentials (VEPs) were used to objectively gauge the subject’s state of attention, and OAEs in response to clicks (transiently evoked OAEs, TEOAEs) were used to gauge inner ear function. As a test of descending neural activity, TEOAE levels were evaluated with and without contralateral acoustic stimulation (CAS) by broadband noise, a paradigm known to activate the MOC pathway. Our results showed that the recorded VEPs were, as expected, a good measure of visual attention, but even when attention levels changed there was no corresponding change in TEOAE levels. We conclude that visual attention does not significantly affect inner ear function.

Some examples of the proton resonance spectra of paramagnetic complexes are discussed, and a qualitative explanation of the large shifts observed is given. The spectra can sometimes give information about the structure of complexes in solution, and also show the relative amounts of different species. The line positions appear to be sensitive to the conformation of the ligand groups. The changes with pH observed in complexes with polydentate amino acids can be explained by a decrease in the mobility of the ligand as chelation increases. The effects of proton exchange and electron exchange are mentioned briefly.

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