The quantification of angiogenesis in relation to metastasis in oral cancer: a review

Hannen, E.J.M.; Riediger, D

doi:10.1054/ijom.2003.0433

Cited by 41 publications

(41 citation statements)

References 51 publications

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“…41,42 Other methods have been developed to evaluate angiogenesis, such as the Chalkley method and flow cytometry vessel counting. 41,42 Using the MVD technique, Shpitzer et al 28 have studied early-stage tongue SCC angiogenesis, reporting that it may be an important factor for tumor hostility. Marked angiogenesis correlated well with the risk of nodal metastases and should probably imply a more aggressive postoperative adjuvant therapy.…”

Section: Review Of the Literature Patient-related Factorsmentioning

confidence: 99%

Oral squamous cell carcinoma: Review of prognostic and predictive factors

Massano

Regateiro

Januário

et al. 2006

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

542

436

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Section: Review Of the Literature Patient-related Factorsmentioning

confidence: 99%

Oral squamous cell carcinoma: Review of prognostic and predictive factors

Massano

Regateiro

Januário

et al. 2006

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

542

436

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“…However, it must be emphasized that neovascularization permits, but does not guarantee, progressive tumor spread [16]. In the head and neck squamous cell carcinomas (HNSCC) this is equivocal [17], and many possible reasons exist like choice of endothelial marker, vascularity of tissue of origin of carcinoma, methodology of counting vessels, lymphangiogenesis, vascular mimicry, mosaic blood vessels, and so on.…”

Section: Angiogenesis and Metastasismentioning

confidence: 99%

Role of angiogenesis in oral squamous cell carcinoma development and metastasis: an immunohistochemical study

et al. 2011

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Although a few studies have shown that vascularity is increased from normal mucosa to dysplasia to carcinoma suggesting that disease progression in the oral mucosa is accompanied by angiogenesis. The role in lymph node metastasis in oral squamous cell carcinoma (OSCC) is equivocal. Role of angiogenesis in OSCC development and metastasis is evaluated in this study. This retrospective study of 50 samples consisted of 9 normal buccal mucosa, 22 leukoplakias, and 19 OSCC. Polyclonal antibodies to von-Willebrand factor were used to highlight the microvessels. Images were captured and morphometric image analysis was done for microvessel density (MVD), area, and perimeter. Highest, as well as mean values of these three parameters were compared. MVD and perimeter, but not area, are significantly different between normal mucosa and OSCC, and leukoplakia and OSCC. There were no differences between normal mucosa and leukoplakia. MVD, area, and perimeter were not significantly different between the OSCC with and without lymph node metastasis. The highest and mean values of MVD are significantly correlated. In the development of OSCC, angiogenic phenotypic change occurs in carcinomas rather than in the pre-cancerous stage, and quantification of angiogenesis in OSCC does not predict the risk of lymph node metastasis.

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“…The other may have been in the relation between the function and size of blood vessels. Hannen and Riediger (2004) reported that large blood vessels in tumours are functional, whereas small ones may represent single endothelial cells without significant perfusion capability. Therefore, there may be regions of tumours with low blood flows and low local O 2 concentrations despite having high BVD.…”

Section: Discussionmentioning

confidence: 99%

Blood vessel density correlates with the effects of targeted intra-arterial carboplatin infusion with concurrent radiotherapy for squamous cell carcinomas of the oral cavity and oropharynx

et al. 2006

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Our aim was first to evaluate the association between blood vessel density (BVD) and free platinum concentration in experimentally induced tumours in rabbits. We also investigated the association between tumour BVD and the clinical response of patients who had undergone targeted carboplatin intra-arterial (i.a.) chemoradiotherapy. VX2 carcinoma cells were transplanted into 46 inbred female Japanese white rabbits. In the i.a. group, carboplatin was infused into the lingual artery, and in the intravenous (i.v.) group, carboplatin was infused through the auricular vein. In the clinical study, we evaluated 19 patients with squamous cell carcinomas of the oral cavity and oropharynx, who had undergone targeted carboplatin i.a. chemoradiotherapy and had been administered i.a. tegafur/uracil chemotherapy before surgery. We quantified angiogenesis in both studies. Increased BVD was associated with a higher free platinum concentration in the tumour region in the i.a. group of rabbits. In the clinical study, using multivariate logistic regression analysis, only the BVD was related independently to the treatment effect. Therefore, BVD is a valid predictor of the effects of i.a. targeted carboplatin chemotherapy and concurrent radiotherapy for treating human oral and oropharyngeal squamous cell carcinomas. British Journal of Cancer (2006) The anticancer effect of superselective chemotherapy is believed to be reinforced when highly concentrated drugs are administered to tumours via supplying arteries (Kar et al, 1986;Moses et al, 1993). However, little evidence has been reported from experimental trials in the oral region. We also hypothesise that the concentration of anticancer drug in a tumour may be associated with the blood vessel density (BVD) in the tumour. Consequently, BVD may influence therapeutic effects, in that different treatment effects may be caused partly by differences in the degree of vascularity of a tumour. Much experimental evidence has shown that tumour growth and metastasis depend on local angiogenesis (Folkman and Klagsbrun, 1987;Horak et al, 1992;Macchiarini et al, 1992) but no study has elucidated the relationship between the effects of chemotherapy and tumour angiogenesis. This study was designed to evaluate the relationship between BVD and free platinum concentrations during intra-arterial (i.a.) chemotherapy. Using transplanted VX2 tongue tumour cells in Japanese white rabbits, and a series of 19 human patients, we evaluated the association between BVD and the effects of concurrent targeted i.a. carboplatin chemotherapy and radiotherapy before surgery in squamous cell carcinomas of the oral cavity and oropharynx. MATERIALS AND METHODS Experimental studyInbred female Japanese white rabbits weighing 3 -4 kg were used throughout the experiment. The animals were anaesthetised via the auricular vein using pentobarbital sodium (1 mg kg À1 ), and then VX2 carcinoma cells were implanted as 0.2 ml injections of cell suspension into the tongue, using a 22-gauge needle. By 3 weeks after implantation, the tu...

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The quantification of angiogenesis in relation to metastasis in oral cancer: a review

Cited by 41 publications

References 51 publications

Oral squamous cell carcinoma: Review of prognostic and predictive factors

Oral squamous cell carcinoma: Review of prognostic and predictive factors

Role of angiogenesis in oral squamous cell carcinoma development and metastasis: an immunohistochemical study

Blood vessel density correlates with the effects of targeted intra-arterial carboplatin infusion with concurrent radiotherapy for squamous cell carcinomas of the oral cavity and oropharynx

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